Associations between serum insulin and homocysteine in a Swedish population—a potential link between the metabolic syndrome and hyperhomocysteinemia: The Skaraborg project

Björck, Joar; Hellgren, Margareta; Råstam, Lennart; Lindblad, Ulf

doi:10.1016/j.metabol.2006.03.010

Cited by 56 publications

(46 citation statements)

References 47 publications

(65 reference statements)

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“…In addition, Abbasi et al and Pouwels et al [37,38] have reported that tHcy was unrelated with insulin resistance in healthy volunteers and diabetic subjects, even after the improvement of insulin sensitivity. In contrast, in a recent work by Bjorck et al analysed in a populationbased sample of Swedish subjects, positive association between serum insulin and serum Hcy independent of age and sex were observed [39], suggesting the possible link between the metabolic syndrome and Hcy. They suggested two plausible theories to explain their results.…”

Section: Discussionmentioning

confidence: 63%

Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration

et al. 2007

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Abstract. Plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular disease and increased tHcy levels have been reported to be a novel risk factor of atherosclerotic disease. The aim of this study was to assess the association of the metabolic syndrome components with plasma (tHcy) level. Total 722 participants (284 men, 438 women) from the medical checkup program were enrolled in this study. The clinical characteristics and biochemical parameters of the subjects were assessed and the tHcy levels were compared according to the components of metabolic syndrome diagnosed by Adult Treatment Panel (ATP) III guideline and International Diabetes Federation (IDF) criteria. Among the components, groups with larger waist circumference and higher fasting blood glucose levels showed significantly higher tHcy level than the counterparts. Although statistically insignificant, mean concentrations of tHcy was higher in subjects with metabolic syndrome defined by both criteria. In multiple regression analysis, age, sex and systolic blood pressure were the independent determinants of tHcy level. In conclusion, tHcy level was not associated with metabolic syndrome defined by either criteria in Korean subjects.

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Section: Discussionmentioning

confidence: 63%

Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration

et al. 2007

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“…Hyperglycemia increases oxidative stress and asymmetric dimethylarginine (ADMA) in the vascular endothelium [35]. Meanwhile, elevated tHcy induces endothelial dysfunction via increased oxidative stress and ADMA [4,36,37]. This oxidative stress affecting tHcy may arise as a result of oxidative damage of vascular endothelial cells and increased proliferation of vascular smooth muscle cells after oxidative metabolism of homocysteine to homocysteine and homocysteine thiolactone.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with serum total homocysteine level in type 2 diabetes

Masuda

Kubo²,

Kokaze

et al. 2008

Environ Health Prev Med

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Objectives The aim of this study was to investigate the determinants of serum total homocysteine level (tHcy) in patients with type 2 diabetes mellitus (DM) according to sex. Methods A total of 1,276 Japanese, diabetics (n = 280) with a control group of non-diabetics (n = 996), were enrolled into the study from 2003 to 2005. This crosssectional study was conducted for all the subjects, using personal data regarding clinical characteristics and lifestyle. Multiple regression analysis was performed to analyze the association of tHcy with selected factors. Results In diabetic subjects, estimated glomerular filtration rate (eGFR) and serum creatinine levels (Cre), even those within the normal range, were strongly associated with tHcy after adjustment in both sexes; the standardized partial regression coefficient of eGFR for tHcy was -0.251, (p = 0.001) in diabetic men and -0.523, (p \ 0.001) in diabetic women. Furthermore, the eGFR of the diabetics, except patients with nephropathy, also had significant association with tHcy in both sexes. Fasting plasma glucose levels and serum triglyceride levels were strongly associated with tHcy in diabetic men only. HbA1c was also associated with tHcy in diabetic men only, though not as significantly. Age and presence of hypertension were significantly associated with tHcy in women. Conclusions This study suggests that there are some differences in the factors associated with tHcy between diabetics and non-diabetics, and between the sexes. There is, therefore, circumstantial evidence that elevated tHcy should be evaluated clinically. Because tHcy was strongly associated with eGFR and Cre, even within the normal ranges, tHcy may have important implications regarding the microangiopathy of the kidney and atherosclerosis.

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“…According to Bjork et al (27), serum Hcy associated positively with serum insulin as well as with insulin resistance independently of age and sex. By contrast, Schachter et al (26) suggested that insulin resistance and hyperinsulinemia in patients with PCOS is associated with elevated plasma Hcy, independently of body weight.…”

Section: Discussionmentioning

confidence: 99%

Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women

Lambrinoudaki

Kaparos²,

Papadimitriou³

et al. 2008

European Journal of Endocrinology

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Objective: To assess the association of genetic polymorphisms related to cardiovascular disease (CVD) risk with anthropometric parameters and indices of androgenicity in healthy postmenopausal women. Design: Cross-sectional study in a University Menopause Clinic. Methods: The following polymorphisms were assessed in 84 healthy postmenopausal women: glycoprotein IIIa Leu33Pro, apolipoprotein E2/E3/E4, methylenetetrahydrofolate reductase (MTHFR) Ala222Val, apolipoprotein B Arg3500Gln, paraoxonase 1 Gln192Arg, plasminogen activator inhibitor 1 4G/5G, cholesterol-7 a-hydroxylase A-204C, and cholesterol ester transfer protein (TaqIB) B1/B2. Hormonal assays included FSH, LH, 17-b-estradiol, testosterone, sex hormone-binding globulin (SHBG), DHEA sulfate, D-4-androstenedione (D4A), free androgen index (FAI), free estrogen index (FEI), and homocysteine (Hcy). The anthropometric components were body mass index (BMI) and waist-to-hip ratio (WHR). Results: MTHFR Ala222Val polymorphism was positively associated with testosterone, FAI, and FEI (PZ0.001, PZ0.0004, and PZ0.014 respectively) and negatively with SHBG (PZ0.047). Furthermore, women bearing this polymorphism had higher BMI and WHR compared with women with the wild-type variant (PZ0.027 and PZ0.044 respectively). Conclusions: MTHFR Ala222Val polymorphism is associated with increased androgenicity and elevated BMI and WHR in healthy postmenopausal women. The significance of this association with respect to the CVD risk of postmenopausal women remains to be elucidated in future studies. European Journal of Endocrinology 159 233-241

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Associations between serum insulin and homocysteine in a Swedish population—a potential link between the metabolic syndrome and hyperhomocysteinemia: The Skaraborg project

Cited by 56 publications

References 47 publications

Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration

Relationship between Metabolic Syndrome Categorized by Newly Recommended by International Diabetes Federation Criteria with Plasma Homocysteine Concentration

Factors associated with serum total homocysteine level in type 2 diabetes

Methylenetetrahydrofolate reductase C677T polymorphism is associated with central adiposity and increased androgenicity in healthy postmenopausal women

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