Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study

Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo

doi:10.1007/s12011-020-02371-w

Cited by 10 publications

(13 citation statements)

References 46 publications

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“…Moreover, the Mn-MetS association could be non-linear, as suggested by some included studies examining Mn exposure from serum [19], urine [2,4], and whole blood [30]. From a physiological perspective, deficient and excessive Mn exposure may relate to a higher risk for metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Nine of the included studies were cross-sectional, three were case-control studies, and all were published between 2013 and 2021. One study was prospective cohort in study design, but the authors only analyzed the association between Mn and MetS using baseline data, and therefore the paper was regarded as cross-sectional study [19]. NCEP ATP III was the most popular diagnostic criteria for MetS (six studies), followed by AHA/NHLBI Scientific Statement (three studies).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Two included studies conducted in China examined the association between Mn from serum and the likelihood of MetS [19,28]. Feng association between the highest Mn level from diet, serum, urine, whole blood, and the likelihood of metabolic syndrome.…”

Section: Serum Mn and Metsmentioning

confidence: 99%

“…Two included studies conducted in China examined the association between Mn from serum and the likelihood of MetS [19,28]. Feng et al analyzed the association of 11 serum metals with MetS among 4303 men who participated in the Fang Chenggang Area Male Health and Examination Survey cohort [19]. As one of the selected serum metals, Mn was only inversely associated with MetS in the second tertile (OR: 0.65, 95% C.I.…”

Section: Serum Mn and Metsmentioning

confidence: 99%

“…= 0.43, 0.98), not the highest tertile (OR: 1.06, 95% C.I. = 0.95, 1.18) [19]. Similarly, the case-control study of 4134 adults conducted by Zhang et al analyzed 15 serum metals and their association with MetS by putting them in the same logistic regression model [28].…”

Section: Serum Mn and Metsmentioning

confidence: 99%

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Manganese Exposure and Metabolic Syndrome: A Systematic Review and Meta-Analysis

Wong

Chan

2022

Nutrients

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Manganese (Mn) is an essential element acting as a co-factor of superoxide dismutase, and it is potentially beneficial for cardiometabolic health by reducing oxidative stress. Although some studies have examined the relationship between Mn and metabolic syndrome (MetS), no systematic review and meta-analysis has been presented to summarize the evidence. Therefore, the present review examined the association between dietary and environmental Mn exposure, and MetS risk. A total of nine cross-sectional studies and three case-control studies were included, which assessed Mn from diet, serum, urine, and whole blood. The association of the highest Mn level from diet (three studies, odds ratio (OR): 0.83, 95% confidence interval (C.I.) = 0.57, 1.21), serum (two studies, OR: 0.87, 95% C.I. = 0.66, 1.14), urine (two studies, OR: 0.84, 95% C.I. = 0.59, 1.19), and whole blood (two studies, OR: 0.92, 95% C.I. = 0.53, 1.60) were insignificant, but some included studies have suggested a non-linear relationship of urinary and blood Mn with MetS, and higher dietary Mn may associate with a lower MetS risk in some of the included studies. While more evidence from prospective cohorts is needed, future studies should use novel statistical approaches to evaluate relative contribution of Mn on MetS risk along with other inter-related exposures.

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