Associations between serum total cholesterol level and bone mineral density in older adults

Sheng, Hu; Wang, Silin; Zhang, Wen‐Xiong; Su, Lang; Ye, Jiayue; Zhang, Deyuan; Zhang, Yang; Guo, Qiang; Yu, Dongliang; Peng, Jinhua; Xu, Jianjun; Wei, Yiping

doi:10.18632/aging.204514

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…However, a study utilizing NHANES data acquired from 2011 to 2018 in the United States demonstrated that serum TC was inversely correlated with BMD among men aged 20–59 years [ 5 ]. A study of cancer-free older adults in the United States revealed a significant negative correlation between serum TC levels and lumbar BMD in men aged > 60 years [ 4 ]. The reason for this difference may be the difference in eating habits and lifestyles between Asians, Europeans, and Americans.…”

Section: Discussionmentioning

confidence: 99%

“…A preclinical study using quantitative computed tomography in mice found that a high-cholesterol diet can lead to low bone content [ 3 ]. Research based on data from the US National Health and Nutrition Examination Survey (NHANES) database has shown that TC is inversely associated with lumbar bone mineral density (BMD) in older non-cancer individuals aged ≥ 60 years [ 4 ]. Another study discovered a correlation between low TC levels and reduced total BMD in young adults aged 20–29 years; in individuals aged 40–49 years and those with borderline diabetes, a non-linear curve associating TC with total BMD was identified, with an inflection point at 4.65 mmol/L and 6.7 mmol/L, respectively [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023

Sun,

Qi,

Lin

et al. 2023

Lipids Health Dis

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Background The impact of total cholesterol (TC) on lumbar bone mineral density (BMD) is a topic of interest. However, empirical evidence on this association from demographic surveys conducted in China is lacking. Therefore, this study aimed to examine the relationship between serum TC and lumbar BMD in a sample of 20,544 Chinese adults between the ages of 20 and 80 years over a period of 5 years, from February 2018 to February 2023. Thus, we investigated the effect of serum TC level on lumbar BMD and its relationship with bone reduction in a Chinese adult population. Methods This cross-sectional study used data obtained from the Department of Health Management at Henan Provincial People’s Hospital between February 2018 and February 2023. The aim of this study was to examine the correlation between serum TC and lumbar BMD in individuals of different sexes. The research methodology encompassed population description, analysis of stratification, single-factor and multiple-equation regression analyses, smooth curve fitting, and analysis of threshold and saturation effects. The R and EmpowerStats software packages were used for statistical analysis. Results After adjusting for confounding variables, a multiple linear regression model revealed a significant correlation between TC and lumbar BMD in men. In subgroup analysis, serum TC was found to have a positive association with lumbar BMD in men, specifically those aged 45 years or older, with a body mass index (BMI) ranging from 24 to 28 kg/m2. A U-shaped correlation arose between serum TC and lumbar BMD was detected in women of different ages and BMI, the inflection point was 4.27 mmol/L for women aged ≥ 45 years and 4.35 mmol/L for women with a BMI of ≥ 28 kg/m2. Conclusion In this study, Chinese adults aged 20–80 years displayed different effects of serum TC on lumbar BMD in sex-specific populations. Therefore, monitoring BMI and serum TC levels in women of different ages could prevent osteoporosis and osteopenia. Trial registration The research protocol was approved by the Ethics Committee of Beijing Jishuitan Hospital, in accordance with the Declaration of Helsinki guidelines (No. 2015-12-02). These data are part of the China Health Quantitative CT Big Data Research team, which has been registered at clinicaltrials.gov (code: NCT03699228).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023

Sun,

Qi,

Lin

et al. 2023

Lipids Health Dis

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“…( 37 )Hu et al. (, 38 ). In recent years, there has been an increasing number of MR studies that have examined the causal relationship between lipid metabolism and bone metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, an increasing number of studies have demonstrated a close correlation between lipid metabolism and bone metabolism, although the conclusions remain debatable. HDL-C, acknowledged as "good" cholesterol with cardiovascular protectionJomard and Osto ( 23 38). In recent years, there has been an increasing number of MR studies that have examined the causal relationship between lipid metabolism and bone metabolism.…”

Section: Discussionmentioning

confidence: 99%

The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study

Kang,

Zhao,

et al. 2023

Front. Endocrinol.

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BackgroundThe impact of lipid metabolism on bone metabolism remains controversial, and the extent to which human traits mediate the effects of lipid metabolism on bone metabolism remains unclear.ObjectiveThis study utilized mendelian randomization to investigate the effects of blood lipids on bone mineral density (BMD) at various skeletal sites and examined the mediating role of human traits in this process.MethodsWe leveraged genetic data from large-scale genome-wide association studies on blood lipids (n=1,320,016), forearm bone mineral density (FA-BMD) (n=10,805), lumbar spine bone mineral density (LS-BMD) (n=44,731), and femoral neck bone mineral density (FN-BMD) (n=49,988) to infer causal relationships between lipid and bone metabolism. The coefficient product method was employed to calculate the indirect effects of human traits and the proportion of mediating effects.ResultsThe results showed that a 1 standard deviation(SD) increase in HDL-C, LDL-C and TC was associated with a decrease in LS-BMD of 0.039 g/cm2, 0.045 g/cm2 and 0.054 g/cm2, respectively. The proportion of mediating effects of systolic blood pressure (SBP) on HDL-C to LS-BMD was 3.17%, but suppression effects occurred in the causal relationship of LDL-C and TC to LS-BMD. Additionally, the proportion of mediating effects of hand grip strength (HGS) on the TC to LS-BMD pathway were 6.90% and 4.60% for the left and right hands, respectively.ConclusionIn conclusion, a negative causal relationship was established between lipid metabolism and bone metabolism. Our results indicated that SBP and HGS served as mediators for the effects of lipid metabolism on bone metabolism.

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“…Data on association between lipid status and the efects of hypolipidemic therapy on bone metabolism is mixed. Both a negative relationship between total cholesterol and low-density lipoprotein cholesterol concentrations and BMD [153][154][155][156][157][158] and a positive association between high-density lipoprotein cholesterol and BMD [159] have been reported. Other studies, however, found that higher serum high-density lipoprotein cholesterol and apolipoprotein B levels (traditionally viewed as a protective for CVD factor) reduced BMD and may increase the risk of osteoporotic fracture (including HF) independently of traditional risk factors for fractures [160][161][162][163][164][165][166].…”

Section: Prognostic Value Of Ckd and Related Factors For Predictingmentioning

confidence: 99%

Chronic Kidney Disease in Patients with Hip Fracture: Prevalence and Outcomes

Fisher,

Wang,

Smith

2024

International Journal of Clinical Practice

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Objective. Although the association between chronic kidney disease (CKD) and osteoporotic fractures is well established, data on CKD combined with hip fracture (HF) are scarce and controversial. We aimed to assess in patients with HF the prevalence of CKD, its impact on hospital mortality and length of stay (LOS) and to determine the prognostic value of CKD to predict hospital outcomes. Methods. Prospectively collected clinical data were analysed in 3623 consecutive HF patients aged ≥65 years (mean age 83.4 ± 7.50 [standard deviation] years; 74.4% females). Results. CKD among older patients with HF is highly prevalent (39.9%), has different clinical characteristics, a 2.5-fold higher mortality rate, and 40% greater risk of prolonged LOS. The strongest risk for a poor outcome was advanced age (>80 years). The risk of death substantially increases in combination with chronic disorders, especially coronary artery disease, anaemia, hyperparathyroidism, and atrial fibrillation; models based only on three variables—CKD stage, age >80, and presence of a specific chronic condition—predicted in-hospital death with good discrimination capability (AUC ≥ 0.700) and reasonable accuracy, the number needed to predict ranged between 5.7 and 14.5. Only 12% of HF patients received osteoporotic drugs prefracture. Conclusion. In HF patients with CKD, the risk of adverse outcomes largely increases in parallel with worsening kidney function and, especially, in combination with comorbidities; models based on three admission variables predict a fatal outcome. Assessment of renal function is essential to preventing osteoporotic fractures.

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Associations between serum total cholesterol level and bone mineral density in older adults

Cited by 4 publications

References 22 publications

Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023

Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023

The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study

Chronic Kidney Disease in Patients with Hip Fracture: Prevalence and Outcomes

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