Associations between sex hormones, sleep problems and depression: A systematic review

Morssinkhof, Margot W.L.; Wylick, D.W. van; Priester-Vink, Simone; Werf, Ysbrand D. van der; Heijer, Martin den; Heuvel, Odile A. van den; Broekman, Birit F.P.

doi:10.1016/j.neubiorev.2020.08.006

Cited by 131 publications

(73 citation statements)

References 78 publications

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“…Counterpart to this protective effect against obstructive sleep apnoea (OSA) may be an increased risk of central apnoea, due to hormone-induced re-setting of chemoreceptors that favours hyperventilation/ hypocapnia coupling, as well as an increased pressor response to hypercapnia and apnoea [10,23,53,54]. Literature shows that high levels of oestrogens promote sleep [55]. At the same time, some studies report that during the luteal phase of the menstrual cycle (the phase where progesterone levels evidently increase) some women may experience worse sleep [56,57].…”

Section: Pathophysiological Mechanisms Underlying the Development Of Insomnia During Pregnancymentioning

confidence: 99%

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Sleep Disorders in Pregnancy

Moretti¹,

Menculini²,

Gonfia³

2022

Sleep Medicine and the Evolution of Contemporary Sleep Pharmacotherapy

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Sleep disturbances and changes in circadian rhythms are commonly observed in pregnant women. These disorders can result from anatomical, physiological, psychological, and hormonal alterations that can influence sleeping during this phase. Sleep disorders during pregnancy can be responsible for detrimental effects on both mother and foetus. In this chapter we will focus on the epidemiology of sleep disorders, physiological sleep mechanisms and their alterations during pregnancy, as well as on risk factors for sleep disorders in pregnancy. We will then focus of the most frequent sleep disorders during pregnancy, also considering eventual adverse implications for both mother and child, prognosis, and possible pharmacological and non-pharmacological treatments.

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Section: Pathophysiological Mechanisms Underlying the Development Of Insomnia During Pregnancymentioning

confidence: 99%

“…Different results from several reports may be consequence of a different individual sleep responses to sex hormones activities. [55].…”

Section: Pathophysiological Mechanisms Underlying the Development Of Insomnia During Pregnancymentioning

confidence: 99%

Sleep Disorders in Pregnancy

Moretti¹,

Menculini²,

Gonfia³

2022

Sleep Medicine and the Evolution of Contemporary Sleep Pharmacotherapy

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“…This finding is also meaningful for PMD, because these two sleep outcomes are usually shown to be less in women with depression compared with the healthy women. 11 Estrogen affects the serotonin system in several ways, including promoting the synthesis of serotonin by increasing the rate of degradation of monoamine oxidase (the enzyme that catabolizes serotonin), and inhibiting the reuptake of serotonin by affecting intraneuronal serotonin transport. 114,153 stimulate the production of neurotransmitters such as serotonin and to enhance serotonergic function in depression and its treatment.…”

Section: Regulation Of Neurotransmittersmentioning

confidence: 99%

“…9 The Comorbidity of Perimenopausal Insomnia and Depression is More Than a "Domino" Effect with sleep disturbance are 10 times more likely to experience depression; and women with depression are more vulnerable to insomnia, particularly waking during the night and having difficulty falling asleep again. 11,12 In various insomnia patterns, depression is highly associated with difficulty falling asleep and waking up earlier than desired. 10 Women in the menopausal transition are at increased risk for sleep-disordered breathing, which can also contribute to both depressed mood and poor sleep.…”

Section: Introductionmentioning

confidence: 99%

“…14 It is challenging to find an established theoretical basis for interpreting intertwined phenomenon of insomnia and depression as women transit menopause, although the two are commonly co-encountered. 4,11 Two kinds of "domino" theory are sometimes asserted to partially explain this bidirectionality, or even link this bidirectionality to vasomotor symptoms: 1) PMD due to climacteric vasomotor symptoms or other psychosocial risk factors decreases sleep quality and quantity and 2) frequent night hot flushes may be tied to disrupted sleep patterns, and in turn, trigger the development of depressive symptoms. 4,5 The complicated interrelationships between these three symptoms (depression, insomnia, and vasomotor complaints), however, may far exceed the "domino" explanation, because not all women with hot flushes develop depression, insomnia, or both; and many perimenopausal women suffer from depression and/or insomnia in the absence of hot flushes.…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause

Zhao¹,

Fu²,

Spencer³

et al. 2021

NSS

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Comorbid depression and insomnia are ubiquitous mental complaints among women going through the perimenopausal stage of life and can result in major decline in quality of life. Antidepressive agents combined with/without hypnotics, and/or hormone therapy are currently the most common treatment for perimenopausal depression (PMD) and insomnia (PMI). Balancing the benefits of these pharmacotherapies against the risk of adverse events (AEs) is a difficult task for both clinicians and women. There has been a growing body of research regarding the utilization of acupuncture for treatment of PMD or PMI, whereas no studies of acupuncture for comorbid PMD and PMI have appeared. In this review, we summarize the clinical and preclinical evidence of acupuncture as a treatment for PMD or PMI, and then discuss the potential mechanisms involved and the role of acupuncture in helping women during this transition. Most clinical trials indicate that acupuncture ameliorates not only PMD/PMI but also climacteric symptoms with minimal AEs. It also regulates serum hormone levels. The reliability of trials is however limited due to methodological flaws in most studies. Rodent studies suggest that acupuncture prolongs total sleep time and reduces depression-like behavior in PMI and PMD models, respectively. These effects are possibly mediated through multiple mechanisms of action, including modulating sex hormones, neurotransmitters, hypothalamic-pituitary-adrenal axis/hypothalamic-pituitary-ovary axis, oxidative stress, signaling pathways, and other cellular events. In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. Neuroendocrine modulation is likely to play a major role in mediating those effects. High-quality trials are required to further validate acupuncture's effectiveness.

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Why It Is Important to Consider the Effects of Analgesics on Sleep: A Critical Review

Iacovides

Kamerman

Baker

et al. 2021

Comprehensive Physiology

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We review the known physiological mechanisms underpinning all of pain processing, sleep regulation, and pharmacology of analgesics prescribed for chronic pain. In particular, we describe how commonly prescribed analgesics act in sleep-wake neural pathways, with potential unintended impact on sleep and/or wake function. Sleep disruption, whether pain-or drug-induced, negatively impacts quality of life, mental and physical health. In the context of chronic pain, poor sleep quality heightens pain sensitivity and may affect analgesic function, potentially resulting in further analgesic need. Clinicians already have to consider factors including efficacy, abuse potential, and likely side effects when making analgesic prescribing choices. We propose that analgesicrelated sleep disruption should also be considered. The neurochemical mechanisms underlying the reciprocal relationship between pain and sleep are poorly understood, and studies investigating sleep in those with specific chronic pain conditions (including those with comorbidities) are lacking. We emphasize the importance of further work to clarify the effects (intended and unintended) of each analgesic class to inform personalized treatment decisions in patients with chronic pain.

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Associations between sex hormones, sleep problems and depression: A systematic review

Cited by 131 publications

References 78 publications

Sleep Disorders in Pregnancy

Sleep Disorders in Pregnancy

Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause

Why It Is Important to Consider the Effects of Analgesics on Sleep: A Critical Review

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