Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men

LʼAbbate, Antonio; Wu, Frederick C. W.; O'Neill, Terence W; Pye, Stephen R.; Carter, Emma L.; Finn, Joseph D.; Rutter, Martin K.; Laurent, Michaël; Huhtaniemi, Ilpo; Han, Thang S.; Lean, Michael E. J.; Keevil, Brian; Pendleton, Neil; Rastrelli, Giulia; Forti, Gianni; Bártfai, György; Casanueva, Felipe F.; Kula, Krzysztof; Punab, Margus; Giwercman, Aleksander; Claessens, Frank; Decallonne, Brigitte; Vanderschueren, Dirk

doi:10.1210/jc.2014-4184

Cited by 104 publications

(68 citation statements)

References 42 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…82,100 Furthermore, the relationship between weight and T is probably bidirectional, since hypogonadism promotes fat accumulation and low total and free serum T levels have been associated with an increased risk of developing metabolic syndrome. 18 Data on the relationship between T and the cardiovascular (CV) system are available from the BLSA, 113 the MrOS, 114 the Tromsø, 110,111,112 and the RBS, 115 showing that hypertension is associated to low serum T ( Table 3). As suggested by the Tromsø study, smoking, overweight, and obesity represent possible confounding factors when evaluating the relationship between serum T and CV diseases in cohort studies.…”

Section: Main Outcomes Of Cohort Studiesmentioning

confidence: 99%

“…5 In addition, several factors (e.g. obesity) [17][18][19][20] and/or comorbidities, 21,22 which become common with advancing age, might modify in percentage amount amount of different T fractions. 7 Several methods are available to measure the different fractions of circulating T. Total serum T is the fraction most commonly measured in clinical practice and is usually assayed with Immunoassays (IAs) in clinical laboratories.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Aging and sex hormones in males

2016

View full text Add to dashboard Cite

Several large cohort studies have disclosed the trajectories of sex steroids changes overtime in men and their clinical significance. In men the slow, physiological decline of serum testosterone (T) with advancing age overlaps with the clinical condition of overt, pathological hypogonadism. In addition, the increasing number of comorbidities, together with the high prevalence of chronic diseases, all further contribute to the decrease of serum T concentrations in the aging male. For all these reasons both the diagnosis of late-onset hypogonadism (LOH) in men and the decision about starting or not T replacement treatment remain challenging. At present, the biochemical finding of T deficiency alone is not sufficient for diagnosing hypogonadism in older men. Coupling hypogonadal symptoms with documented low serum T represents the best strategy to refine the diagnosis of hypogonadism in older men and to avoid unnecessary treatments.

show abstract

Section: Main Outcomes Of Cohort Studiesmentioning

confidence: 99%

mentioning

confidence: 99%

Aging and sex hormones in males

2016

View full text Add to dashboard Cite

show abstract

“…Declining testicular function and hypothalamic dysfunction would be the mechanisms explaining the fall in testosterone levels with age. The increased prevalence of obesity and chronic illness in ageing men are responsible for the large reduction of testosterone levels [55].…”

Section: Androgen-deprivation Therapy Late-onset Hypogonadism (Loh) mentioning

confidence: 99%

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review]

Takayama

2017

Endocr J

View full text Add to dashboard Cite

Abstract. Hormonal alterations with aging contribute to the pathogenesis of several diseases. Androgens mediate their effects predominantly through binding to the androgen receptor (AR), a member of the ligand-dependent nuclear receptor superfamily. By androgen treatment, AR is recruited to specific genomic loci dependent on tissue specific pioneer factors to regulate target gene expression. Recent studies have revealed the epigenetic modulation by AR-associated histone modifiers and the roles of non-coding RNAs in AR signaling. Androgens are male sex hormone to induce differentiation of the male reproductive system required for the establishment of adult sexual function. As shown by several reports using AR knockout mouse models, androgens also have anabolic functions in several tissues such as bone, muscle and central nervous systems. Notably, AR has a central role in prostate cancer progression. Prostate cancer is the most frequently diagnosed cancer in men. Androgen-deprivation therapy for cancer patients and decline of serum androgen with aging promote several diseases associated with aging and quality of life of older men such as osteoporosis, sarcopenia and dementia. Thus, androgen replacement therapy for treating late onset hypogonadism (LOH) or new epigenetic regulators have the potential to overcome the symptoms caused by the low androgen, although adverse effects for cardiovascular diseases have been reported. Given the increasing longevity and consequent rise of age-related diseases and prostate cancer patients, a more understanding of the AR actions in male health remains a high research priority.

show abstract

“…Само по себе висцеральное ожирение ассоциируется со снижением уровня тестостерона [34]. СД2 также часто наблюдается у лиц с низкими уровнями тестостерона в сочетании с другими симптомами гипогонадизма [35][36][37][38].…”

Section: клинические последствия гипогонадизмаunclassified

Guidelines for the diagnosis and treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus (Draft)

et al. 2017

View full text Add to dashboard Cite

Клинические рекомендацииClinical guidelines вторы и рецензенты представляют собой меж-дисциплинарную группу экспертов, состоящую из эндокринологов, андрологов, урологов. Ре-комендации публикуются впервые. Клинические ре-комендации содержат самые надежные доказательства, доступные экспертам на момент создания. Однако реко-

show abstract

Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men

Abstract: In men, lower T levels, but not E2, are linked with an increased risk of developing MetS, independent of SHBG, BMI or insulin resistance. A lower E2/T ratio may be protective against developing MetS.

Cited by 104 publications

References 42 publications

Aging and sex hormones in males

Aging and sex hormones in males

The biological and clinical advances of androgen receptor function in age-related diseases and cancer [Review]

Guidelines for the diagnosis and treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus (Draft)

Contact Info

Product

Resources

About