Associations between sleep disturbances and suicidal ideation, plans, and attempts in adolescents: a systematic review and meta-analysis

Liu, Jen Wei; Tu, Yu–Kang; Lai, Ying Fan; Lee, Hsin Chien; Tsai, Pei Shan; Chen, Ting Jhen; Huang, Hui; Chen, Yuting; Chiu, Hsiao‐Yean

doi:10.1093/sleep/zsz054

Cited by 98 publications

(51 citation statements)

References 46 publications

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“…Previous studies have confirmed that sleep was associated with suicidal ideation. 32 This is because poor sleep can lead to a state of trance and hopelessness, which may lead to suicidal thoughts. 33 In addition, poor sleep can increase the risk of suicide through a variety of physiological mechanisms, including hypothalamic pituitary adrenal (HPA) axis dysfunction and 5-hydroxytryptamine (5-HT) dysfunction, among others.…”

Section: Discussionmentioning

confidence: 99%

<p>The Effect and Mechanism of Adverse Childhood Experience on Suicide Ideation in Young Cancer Patients During Coronavirus Disease 2019 (COVID-19) Pandemic</p>

Yang¹,

Xiao²,

et al. 2020

RMHP

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Background and Aim: Coronavirus disease 2019 (COVID-19) is currently prevalent worldwide. This research aimed to explore the effect of adverse childhood experience (ACE) on suicide ideation in young cancer patients during the COVID-19 pandemic. Selfreported questionnaires analyzed the mediating effects of sleep quality, anxiety symptoms, and inflammatory conditions between ACE and suicide ideation. Materials and Methods: A total of 197 young cancer patients (age 18-40) completed questionnaires and a blood test. Correlation analysis and structural equation model were used to explore the relationships between ACE, sleep quality, anxiety symptom, serum C-reactive protein (CRP) levels and suicide ideation. The mediating roles of sleep quality, anxiety symptoms, and CRP levels on the influence of ACE on suicide ideation were explored. Results: ACE was positively related to anxiety symptoms, CRP levels, and suicide ideation, and negatively related to sleep quality. Anxiety symptoms and CRP levels were positively related to suicide ideation, while sleep quality was negatively related to suicide ideation. Anxiety symptoms were positively related to CRP levels but negatively related to sleep quality. From these results, we found ACE affected suicide ideation directly and was mediated by roles sleep quality, anxiety symptom and CRP. Conclusion: ACE not only directly affected suicide ideation but also affected suicide ideation through sleep quality, anxiety symptoms, and inflammatory conditions in young cancer patients during the COVID-19 pandemic. Therefore, targeted intervention and help for cancer patients from the perspective of ACE should be put into practice.

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Section: Discussionmentioning

confidence: 99%

<p>The Effect and Mechanism of Adverse Childhood Experience on Suicide Ideation in Young Cancer Patients During Coronavirus Disease 2019 (COVID-19) Pandemic</p>

Yang¹,

Xiao²,

et al. 2020

RMHP

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“…Results from psychological autopsy indicate that, when compared to depressed adolescent suicide attempters and controlling for depression severity, adolescents who died by suicide were 5 times more likely to have had insomnia during the week before death, 4 times more likely to have had sleep problems of any kind, and 10 times more likely to have had sleep problems as part of their mood disturbance during the year before death (Goldstein et al, 2008). Accumulating research indicates associations between sleep disturbance, self‐harm, and indicators of elevated suicide risk in community (for review, Liu et al, 2019) and clinical samples (McGlinchey, Courtney‐Seidler, German, & Miller, 2017; Stanley et al, 2017; Zullo et al, 2017; Koyawala, Stevens, Mcbee‐Strayer, Cannon, & Bridge, 2015). However, to our knowledge prior studies have not evaluated these associations prospectively, in more homogenous samples selected specifically for indicators of very high suicide/self‐harm risk, such as the combination of repeated self‐harm, suicide attempts, and suicidal ideation.…”

Section: Introductionmentioning

confidence: 99%

Sleep in youth with repeated self‐harm and high suicidality: Does sleep predict self‐harm risk?

Asarnow

Bai

Babeva

et al. 2020

Suicide & Life Threat Behav

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Objective To elucidate processes contributing to continuing self‐harm in youth at very high risk for suicide, focusing on sleep disturbance, a putative warning sign of imminent suicide risk. Method 101 youth (ages 12–18) selected for high risk of suicide/suicide attempts based on suicidal episodes plus repeated self‐harm (suicide attempts and/or nonsuicidal self‐injury [NSSI]). Youth were assessed at baseline, 6‐, and 12‐month follow‐ups on measures of self‐harm, suicidality, sleep, and depression. Results Youth showed high rates of baseline sleep disturbance: 81.2% scored in the clinical range on the Pittsburgh Sleep Quality Index (PSQI); 81.2% reported an evening (night owl) circadian preference. PSQI score was associated with elevated levels of self‐harm (suicide attempts and NSSI) contemporaneously and predicted future self‐harm within 30 days. Rates of self‐harm were high during follow‐up: 45.0% and 33.7% at 6 and 12 months, respectively. Conclusions Results underscore the need to move beyond an acute treatment model to prevent recurrent and potentially deadly self‐harm, the importance of clarifying mechanisms contributing to elevated suicide/self‐harm risk, and the potential promise of engaging sleep as a therapeutic target for optimizing treatment and elucidating mechanistic processes.

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“…Notably, these relationships remain significant after controlling for symptoms of co-morbid mental illness. The association between sleep disorders and suicidal experiences has been replicated in a wide range of studies; in both clinical [5] and non-clinical populations [3], spanning wide age-ranges including adolescents [6] to older adults [7], and using subjective and objective assessment of sleep disturbance [8].…”

mentioning

confidence: 90%

Is there a role for sleep medicine in suicide prevention?

Littlewood

Russell

2020

Sleep Medicine

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Associations between sleep disturbances and suicidal ideation, plans, and attempts in adolescents: a systematic review and meta-analysis

Cited by 98 publications

References 46 publications

<p>The Effect and Mechanism of Adverse Childhood Experience on Suicide Ideation in Young Cancer Patients During Coronavirus Disease 2019 (COVID-19) Pandemic</p>

<p>The Effect and Mechanism of Adverse Childhood Experience on Suicide Ideation in Young Cancer Patients During Coronavirus Disease 2019 (COVID-19) Pandemic</p>

Sleep in youth with repeated self‐harm and high suicidality: Does sleep predict self‐harm risk?

Is there a role for sleep medicine in suicide prevention?

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