Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

Chen, Zuo; Wang, Dingqiao; Guo, Xinxing; Xiao, Hui; Zheng, Shaoyang; Lin, Mingkai; Fang, Lei; Xing, Liu

doi:10.3389/fmed.2021.747720

Cited by 2 publications

(8 citation statements)

References 38 publications

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“…39 Similarly, our findings showed that higher IOP was significantly related to lower CVI, although many studies suggest that CVI is relatively unaffected by various factors. 14,15 We hypothesize that elevated IOP has a mechanical effect on the choroid and its vascularity. The hypothesized mechanism is that high IOP can cause mechanical stress and deformation of the choroidal vasculature.…”

Section: Discussionmentioning

confidence: 99%

“…The process of obtaining CVI is shown in Figure 1. This was described in detail in previous articles 15 . The CVI is defined as the proportion of the LA to the TCA.…”

Section: Methodsmentioning

confidence: 99%

“…This was described in detail in previous articles. 15 The CVI is defined as the proportion of the LA to FIGURE 1. Original (A) and binarized SD-OCT images (B).…”

Section: Image Binarization For Choroidal Vascularity Index Measurementmentioning

confidence: 99%

“…The CVI is defined as the ratio of the luminal area (LA) to the total choroidal area (TCA); 13 this index can be used to evaluate the changes in choroidal subcomponents, including blood vessels and stromal tissue. Moreover, several studies, including our previous one, have proposed that CVI is a more reliable and objective marker for assessing choroidal vascular dysregulation than subfoveal choroidal thickness (SFCT) 14,15 . Nevertheless, no previous study has compared the CVI between POAG and PACG.…”

mentioning

confidence: 99%

“…Moreover, several studies, including our previous one, have proposed that CVI is a more reliable and objective marker for assessing choroidal vascular dysregulation than subfoveal choroidal thickness (SFCT). 14,15 Nevertheless, no previous study has compared the CVI between POAG and PACG. Evaluation of the choroidal structure changes in POAG and PACG is critical to understanding the different pathogenes of these two subtypes of glaucoma.…”

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confidence: 99%

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Comparison of the Choroid in Primary Open Angle and Angle Closure Glaucoma Using Optical Coherence Tomography

Wang,

Xiao,

Lin

et al. 2023

Journal of Glaucoma

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Précis: The current study highlights distinct choroidal alterations in primary open-angle and angle-closure glaucoma, underscoring the potential of choroidal vascularity index as a valuable indicator for understanding glaucoma pathogenesis. Purpose: To evaluate choroidal structural changes in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) and healthy controls utilizing the choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) by enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: This study was cross-sectional. A total of 171 eyes of 171 subjects, comprising 69 eyes with untreated POAG, 58 eyes with untreated PACG and 44 healthy eyes, were enrolled in this study. SFCT, luminal area (LA), stromal area (SA) and total choroidal area (TCA) were measured on EDI-OCT scans. The CVI parameter is calculated as the proportion of LA to TCA. Results: This study included 69 POAG patients with a mean age of 51.4±13.3 years, 58 PACG patients with a mean age of 57.0±7.3 years, and 44 healthy subjects with a mean age of 51.11±10.7 years. The CVI in the POAG and PACG groups was significantly lower than that in the control group (P = 0.001 and P = 0.005, respectively), however not significantly different between the two glaucoma groups (P = 1.000). POAG eyes had significantly lower LA than PACG and controls (P = 0.014 and P = 0.049, respectively), while PACG eyes had significantly greater SA than controls (P = 0.041). Conclusions: The CVI of POAG and PACG eyes was significantly lower than that of normal eyes. A reduced LA was observed mainly in eyes with POAG, and an increased SA was observed mainly in eyes with PACG. The role of the choroid may differ between POAG and PACG eyes.

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Section: Discussionmentioning

confidence: 99%

“…The process of obtaining CVI is shown in Figure 1. This was described in detail in previous articles 15 . The CVI is defined as the proportion of the LA to the TCA.…”

Section: Methodsmentioning

confidence: 99%

“…This was described in detail in previous articles. 15 The CVI is defined as the proportion of the LA to FIGURE 1. Original (A) and binarized SD-OCT images (B).…”

Section: Image Binarization For Choroidal Vascularity Index Measurementmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Comparison of the Choroid in Primary Open Angle and Angle Closure Glaucoma Using Optical Coherence Tomography

Wang,

Xiao,

Lin

et al. 2023

Journal of Glaucoma

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Effect of trabeculectomy in the treatment of primary angle-closure glaucoma combined with cataract: A case control study

Cao,

Ou,

Zhou

et al. 2023

Preprint

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Background Elderly cataract patients usually accompany primary angle-closure glaucoma (PACG), leading to a series of pathophysiological changes in the patient’s eyes. While, the treatment of PACG combined with cataracts remains controversial. Methods A retrospective case control study was conducted. One hundred patients with PACG comorbid with cataract who were treated by phacoemulsification, intraocular lens implantation and trabeculectomy were selected as the study group. And another one hundred patients with PACG comorbid with cataract who were treated by phacoemulsification and intraocular lens implantation were selected as the control group. The intraocular pressure (IOP), best corrected visual acuity (BCVA), corneal endothelial cell density, average cell area, anterior chamber depth, anterior chamber angle width, and surgery complications before and after surgery were compared between the two groups. Results One month and three months after surgery, the IOP and BCVA of the study group were lower than those of the control group (P < 0.05). The corneal endothelial cell density of patients in the two groups at one and three months after operation was lower than that before the operation (P < 0.05), and the average cell area was larger than that before the operation (P < 0.05). There was no significant difference in the depth of the anterior chamber and the width of the anterior chamber angle between the two groups (P > 0.05). The depth and width of the anterior chamber angle in the study group were higher than those of the control at one month and three months after surgery (P < 0.05). The complication rate was lower in the study group than in the control group (P < 0.05). Conclusions Phacoemulsification, intraocular lens implantation and trabeculectomy for the treatment of PACG patients with cataract is effective and safe.

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Associations Between the Choroidal Vascularity Index and Malignant Glaucoma After Trabeculectomy for Primary Angle Closure Glaucoma

Cited by 2 publications

References 38 publications

Comparison of the Choroid in Primary Open Angle and Angle Closure Glaucoma Using Optical Coherence Tomography

Comparison of the Choroid in Primary Open Angle and Angle Closure Glaucoma Using Optical Coherence Tomography

Effect of trabeculectomy in the treatment of primary angle-closure glaucoma combined with cataract: A case control study

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