Associations between the FKBP5 haplotype, exposure to violence and anxiety in females

Isaksson, Johan; Comasco, Erika; Åslund, Cecilia; Rehn, Mattias; Tuvblad, Catherine; Andershed, Henrik; Nilsson, Kent W.

doi:10.1016/j.psyneuen.2016.07.206

Cited by 25 publications

(14 citation statements)

References 53 publications

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“…This finding adds to the growing number of studies examining both sexes, in rodents and humans, that demonstrate how sex can contribute to differences in brain development, biological regulation, and emotional reactivity throughout the lifespan [28,29,30,31,32]. To our interest, clinical studies have reported higher anxiety prevalence and poor brain connectivity in women who were previously exposed to trauma and carriers of FKBP5 risk variants [33,34]. In addition to elevated FKBP5 levels, other factors, such as hormones and activity of steroid receptors, may also impact anxiety levels in females.…”

Section: Discussionmentioning

confidence: 81%

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Criado‐Marrero

Gebru

Gould

et al. 2019

IJMS

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Clinical studies show a significant association of childhood adversities and FK506-binding protein 5 (FKBP5) polymorphisms on increasing the susceptibility for neuropsychiatric disorders. However, the mechanisms by which early life stress (ELS) influences FKBP5 actions have not been fully elucidated. We hypothesized that interactions between ELS and high FKBP5 induce phenotypic changes that correspond to underlying molecular changes in the brain. To test this, we exposed newborn mice overexpressing human FKBP5 in the forebrain, rTgFKBP5, to ELS using a maternal separation. Two months after ELS, we observed that ELS increased anxiety levels, specifically in mice overexpressing FKBP5, an effect that was more pronounced in females. Biochemically, Protein kinase B (AKT) phosphorylation was reduced in the dorsal hippocampus in rTgFKBP5 mice, which demonstrates that significant molecular changes occur as a result of ELS when FKBP5 levels are altered. Taken together, our results have a significant impact on our understanding mechanisms underlying the gene x environment interaction showing that anxiety and AKT signaling in the hippocampus were affected by the combination of ELS and FKBP5. An increased knowledge of the molecular mechanisms underlying these interactions may help determine if FKBP5 could be an effective target for the treatment of anxiety and other mood-related illnesses.

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Section: Discussionmentioning

confidence: 81%

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Criado‐Marrero

Gebru

Gould

et al. 2019

IJMS

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“…Previous gene-environment studies have found associations between the variability of this gene and early trauma with depression 73 74 and anxiety. 75 Based on these findings, our main aim is to explore, for the first time, the moderator role of the interaction between FKBP5 gene polymorphisms and childhood trauma on the response to psychological treatments for chronic pain and depression.…”

Section: Discussionmentioning

confidence: 99%

Efficacy, cost-utility and physiological effects of Acceptance and Commitment Therapy (ACT) and Behavioural Activation Treatment for Depression (BATD) in patients with chronic low back pain and depression: study protocol of a randomised, controlled trial including mobile-technology-based ecological momentary assessment (IMPACT study)

et al. 2020

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IntroductionThe IMPACT study focuses on chronic low back pain (CLBP) and depression symptoms, a prevalent and complex problem that represents a challenge for health professionals. Acceptance and Commitment Therapy (ACT) and Brief Behavioural Activation Treatment for Depression (BATD) are effective treatments for patients with persistent pain and depression, respectively. The objectives of this 12 month, multicentre, randomised, controlled trial (RCT) are (i) to examine the efficacy and cost-utility of adding a group-based form of ACT or BATD to treatment-as-usual (TAU) for patients with CLBP and moderate to severe levels of depressive symptoms; (ii) identify pre–post differences in levels of some physiological variables and (iii) analyse the role of polymorphisms in the FKBP5 gene, psychological process measures and physiological variables as mediators or moderators of long-term clinical changes.Methods and analysisParticipants will be 225 patients with CLBP and moderate to severe depression symptoms recruited at Parc Sanitari Sant Joan de Déu (St. Boi de Llobregat, Spain) and Hospital del Mar (Barcelona, Spain), randomly allocated to one of the three study arms: TAU vs TAU+ACT versus TAU+BATD. A comprehensive assessment to collect clinical variables and costs will be conducted pretreatment, post-treatment and at 12 months follow-up, being pain interference the primary outcome measure. The following physiological variables will be considered at pretreatment and post-treatment assessments in 50% of the sample: immune-inflammatory markers, hair cortisol and cortisone, serum cortisol, corticosteroid-binding globulin and vitamin D. Polymorphisms in the FKBP5 gene (rs3800373, rs9296158, rs1360780, rs9470080 and rs4713916) will be analysed at baseline assessment. Moreover, we will include mobile-technology-based ecological momentary assessment, through the Pain Monitor app, to track ongoing clinical status during ACT and BATD treatments. Linear mixed-effects models using restricted maximum likelihood, and a full economic evaluation applying bootstrapping techniques, acceptability curves and sensitivity analyses will be computed.Ethics and disseminationThis study has been approved by the Ethics Committee of the Fundació Sant Joan de Déu and Hospital del Mar. The results will be actively disseminated through peer-reviewed journals, conference presentations, social media and various community engagement activities.Trial registration numberNCT04140838

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“…Like other studies [11,13,17], workplace violence experiences among Korean workers were associated with poorer mental and physical health. Experiencing verbal or physical workplace violence can elevate stress hormone levels, leading directly to increased anxiety, depressive moods [25], and sleep disorders [6]. Workplace violence can cause workers tension or strain, which can increase the risk of musculoskeletal disease [26].…”

Section: Discussionmentioning

confidence: 99%

Associations between Workplace Violence, Mental Health and Physical Health among Korean Employees: The Fifth Korea Youth Working Conditions Survey (2017)

Hr¹

2020

Preprint

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Background This study assessed workplace violence experiences among Korean employees and its influence on mental and physical health.Methods Using the 2017 Fifth Korea Youth Working Conditions Survey, 50,205 workers were analyzed. Experiences of workplace violence were assessed across four categories: verbal violence, unwanted sexual attention, threatening behavior, and humiliation. Mental health included anxiety, sleep problems, depressive symptoms, and physical health included hearing loss/dermatological problems, back pain, limbs myalgia, headache/eye stain, occupational injury, and overall fatigue.Results Experience of workplace violence was more common among workers with poor health (subjectively measured), chronic disease, long weekly working hours, shift work, or jobs in the service industry. Experience of workplace violence was associated with increased anxiety, sleep problems, depression symptoms, and physical health problems.Conclusions Prevention of workplace violence is essential to improve the health of workers.

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Associations between the FKBP5 haplotype, exposure to violence and anxiety in females

Cited by 25 publications

References 53 publications

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

Associations between Workplace Violence, Mental Health and Physical Health among Korean Employees: The Fifth Korea Youth Working Conditions Survey (2017)

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