Associations between the IL-4 -590 T allele and Plasmodium falciparum infection prevalence in asymptomatic Fulani of Mali

Vafa, Manijeh; Maiga, Bakary; Berzins, Klavs; Hayano, Masashi; Bereczky, Sándor; Dolo, Amagana; Daou, Modibo; Arama, Charles; Kouriba, Bourèma; Färnert, Anna; Doumbo, Ogobara K.; Troye‐Blomberg, Marita

doi:10.1016/j.micinf.2007.04.011

Cited by 35 publications

(28 citation statements)

References 27 publications

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“…For example, studies have shown that the IL4-590 T allele is present in 75% of the Fulani, twice the frequency compared to their sympatric neighbors, raising the possibility that differences in IL-4 expression and/or function plays a role in protection from malaria (Vafa et al, 2007(Vafa et al, , 2009b. Moreover, the same study reported an association between the IL-4-590 T allele and the prevalence of P. falciparum infection within the Fulani but not in the Dogon (Vafa et al, 2007).…”

Section: Human Genetic Variations and Sympatric Ethnicity Difference mentioning

confidence: 98%

Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa?

et al. 2015

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Section: Human Genetic Variations and Sympatric Ethnicity Difference mentioning

confidence: 98%

Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa?

et al. 2015

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“…Interestingly, several studies have shown that ethnically diverse African populations may differ in regard to genetic susceptibility to malarial infection. A variant in the promoter region of the IL4 gene, for example, is associated with a decrease in P. falciparum infection in the pastoralist Fulani from Mali, as evidenced by lower parasite load, but no such genetic association is observed in the neighboring agriculturalist Dogon population (52,213). Other studies also reported lower prevalence of malaria parasites and fewer clinical attacks of malaria among the Fulani compared to other ethnically distinct populations in neighboring villages (107,133, 152a).…”

Section: Malariamentioning

confidence: 99%

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

Campbell

Tishkoff

2008

Annu. Rev. Genom. Hum. Genet.

680

573

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Comparative studies of ethnically diverse human populations, particularly in Africa, are important for reconstructing human evolutionary history and for understanding the genetic basis of phenotypic adaptation and complex disease. African populations are characterized by greater levels of genetic diversity, extensive population substructure, and less linkage disequilibrium (LD) among loci compared to non-African populations. Africans also possess a number of genetic adaptations that have evolved in response to diverse climates and diets, as well as exposure to infectious disease. This review summarizes patterns and the evolutionary origins of genetic diversity present in African populations, as well as their implications for the mapping of complex traits, including disease susceptibility.

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“…Polymorphisms of IL4, IL12B and IL13 have been associated with severe malaria, [5][6][7] whereas the IL4-590T allele has been associated with infection prevalence, but not with parasitemia. 8 Moreover, IRF-1 polymorphisms that influence the expression of both IL4 and IL12B were associated with carriage of P. falciparum infection and severe malaria. 9 Chromosome 5q31-q33 contains numerous immunoregulatory genes, which may be involved in the control of P. falciparum infection.…”

Section: Introductionmentioning

confidence: 99%

IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso

et al. 2008

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Chromosome 5q31-q33 has been linked to Plasmodium falciparum parasitemia in several independent studies. This chromosomal region contains numerous immunoregulatory genes. Among these, IL12B that encodes the p40 subunit of interleukin-12 (IL-12) appeared to be a promising functional candidate gene, and IL12Bpro, a promoter polymorphism, was associated with mortality from severe malaria in children. In this study, we characterized genetic variation in IL12B in 215 individuals belonging to 34 families and evaluated linkage and association of parasitemia with IL12B polymorphisms and haplotypes. We searched for IL12B polymorphisms in the coding regions and the corresponding intron-exon borders. We also examined IL12Bpro and IL12B 3 0 untranslated region (UTR) polymorphisms, which are thought to influence the production of IL-12. We showed a high level of conservation of IL12B-coding regions and identified five polymorphisms in introns and the two polymorphisms in the promoter and the 3 0 UTR regions. Although IL12B polymorphisms were linked to parasitemia, there was association of parasitemia with neither polymorphisms nor haplotypes. We cannot exclude that an unknown IL12B cis-regulatory element polymorphism affects both IL-12 production and parasitemia. However, our results suggest that genetic variation in IL12B does not explain differences in parasitemia in individuals living in an endemic area.

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Associations between the IL-4 -590 T allele and Plasmodium falciparum infection prevalence in asymptomatic Fulani of Mali

Cited by 35 publications

References 27 publications

Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa?

Ethnic differences in susceptibility to malaria: What have we learned from immuno-epidemiological studies in West Africa?

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

IL12B polymorphisms are linked but not associated with Plasmodium falciparum parasitemia: a familial study in Burkina Faso

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