Associations between the number of antipsychotics prescribed and metabolic parameters in Japanese patients with schizophrenia

Abstract

Aim: There is little evidence on the effects of antipsychotic polypharmacy on metabolic parameters in patients with schizophrenia. Thus, this cross-sectional study explored the associations between the number of antipsychotics prescribed and metabolic parameters in Japanese patients with schizophrenia. Methods:We obtained metabolic parameter data from 19,675 patients with schizophrenia. Of these, 1380 (7.0%), 8422 (42.8%), 6326 (32.2%), and 3547 (18.0%) were treated with none, one, two, and three or more antipsychotics, respectively. We compared eight metabolic parameters among the four groups using univariate analyses.We then performed multiple regression analysis to assess the effect of the number of antipsychotics prescribed on metabolic parameters after controlling for the effects of age, sex, type of care (outpatient/inpatient), chlorpromazine-equivalent dose, and antipsychotic type (aripiprazole, olanzapine, and risperidone).Results: There were significant differences in body mass index (BMI), systolic and diastolic blood pressure (dBP), total cholesterol, low-density lipoprotein cholesterol, and triglycerides among the four groups. The multiple regression analysis showed that the

Association Between the Number of Remaining Teeth and Body Mass Index in Japanese Inpatients with Schizophrenia

“…The current results replicated the finding in our previous study, which revealed an association between the number of antipsychotics prescribed and BMI in 19,675 patients with schizophrenia. 13 In the current study, 115 of 212 (54.2%) inpatients with schizophrenia received antipsychotic polypharmacy. Notably, 35 (16.5%) inpatients were treated with three or more antipsychotics.…”

“…In our previous study, 52.3% and 19.5% of 14,234 Japanese inpatients with schizophrenia received antipsychotic polypharmacy and three or more antipsychotics, respectively. 13 Moreover, another recent study reported that 42.9% and 24.1% of 2177 Japanese inpatients with schizophrenia received antipsychotic polypharmacy and three or more antipsychotics, respectively, at discharge. 20 To minimize adverse effects of antipsychotics on BMI, psychiatrists should avoid inappropriate antipsychotic polypharmacy, especially polypharmacy involving three or more antipsychotics.…”

“…Our recent study has shown that age, sex, type of care (outpatient/inpatient), the number of antipsychotics prescribed, aripiprazole, and olanzapine were correlated with BMI in 19,675 patients with schizophrenia. 13 Among these variables, being an outpatient was the most strongly correlated with BMI. To control the effects of type of care, we included inpatients with schizophrenia in the current study.…”

“…The Decayed-Missing-Filled Teeth score was associated with BMI in 878 Taiwanese inpatients with schizophrenia, 11 but not in 425 Chinese inpatients with schizophrenia. 12 Here, we performed a cross-sectional study to examine the effects of the number of remaining teeth and relevant variables (eg, age, sex, and the number of antipsychotics prescribed) 13 on BMI in Japanese inpatients with schizophrenia. Our recent study has shown that age, sex, type of care (outpatient/inpatient), the number of antipsychotics prescribed, aripiprazole, and olanzapine were correlated with BMI in 19,675 patients with schizophrenia.…”

Metabolic syndrome and its relation to antipsychotic polypharmacy in schizophrenia, schizoaffective and bipolar disorders

“…We found, however, a negative correlation between oral atypical antipsychotics and BMI and fasting blood glucose. A study by Watanabe et al . (2022) in Japan reported that the number and type of antipsychotics are significantly associated with diastolic blood pressure and obesity while Aly El-Gabry et al .…”