Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI

Krug, Roland; Joseph, G.B.; Han, Misung; Fields, Aaron J.; Cheung, Justin; Mundada, Maya; Bailey, Jeannie F.; Rochette, Alice; Ballatori, Alexander; McCulloch, Charles E.; McCormick, Zachary L.; O’Neill, Conor; Link, Thomas M.; Lotz, Jeffrey C.

doi:10.1002/jmri.26914

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“…In the present investigation, the level of IVDD was assessed by the lumbar DHI and the modified Pfirrmann grading system [ 11 , 12 ]. Akeda K et al observed that the DHI of the elderly would decrease significantly over a decade, accompanied by an increase in the Pfirrmann grading score [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

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Correlation Analysis between Tamoxifen and Lumbar Intervertebral Disc Degeneration: A Retrospective Case-Control Study

Zhao

Rudd

et al. 2022

Pain Research and Management

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Objectives. To investigate the correlation between tamoxifen (TAM) and lumbar intervertebral disc (IVD) degeneration (IVDD). Methods. The patients who visited the department of spine surgery from January 2015 to December 2020 were retrospectively reviewed. Those with a history of breast cancer surgery were identified and their data were collected. These data included patients' age, body mass index (BMI), menstrual history, postoperative history, drug treatment plan, and imaging data. The participants were divided into the TAM group and the non-TAM group. Lumbar IVDD was assessed by lumbar lordosis (LL), vertebral CT density, lumbar disc height index (DHI), Modic changes, and modified Pfirrmann grading score. SPSS 20 was used for statistical analysis. Results. A total of 75 patients were included in this study, 46 patients in the TAM group and 29 patients in the non-TAM group. No significant differences were present in age, BMI, postoperative history, LL, and vertebral CT density between the two groups. The DHI of L1/2 and L2/3 in the TAM group was lower compared to the non-TAM group ( P = 0.038 and P = 0.034 , respectively), while comparisons regarding the DHI of L3/4, L4/5, and L5/S1, and the average DHI between TAM and non-TAM groups were not significant. The modified Pfirrmann grading scores of the L1/2 and L2/3 IVDs in the TAM group were higher than those in the non-TAM group ( P = 0.004 and P = 0.025 , respectively). Comparisons of L3/4, L4/5, and L5/S1 between the two groups were not significant. The comparisons regarding the occurrence of Modic changes did not show a significant difference between the TAM and non-TAM groups. Conclusions. This study indicates that there might be some positive correlation between TAM use and lumbar IVDD. In particular, the degeneration of L1/2 and L2/3 has shown a correlation with TAM use.

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Section: Discussionmentioning

confidence: 99%

“…Lumbar lordosis (LL) was measured by a lumbar X-ray or CT of the angle between the tangent line of the upper endplate of the L1 vertebral body and the S1 vertebral body in the lateral lumbar spine ( Figure 1(a) ). The lumbar disc height index (DHI) was calculated using the following formula ( Figure 1(b) ) [ 11 , 12 ]:

…”

Section: Methodsmentioning

confidence: 99%