Associations between vitamin D receptor genetic variants and tuberculosis: a meta-analysis

Abstract

We performed a meta-analysis to evaluate potential associations between vitamin D receptor ( VDR) genetic variants and tuberculosis (TB). Systematic literature research was conducted in PubMed, Web of Science, and Embase. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations in all possible genetic models, and P values ≤ 0.05 were considered to be statistically significant. In total, 42 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rs1544410 (dominant model: P = 0.02; allele model: P = 0.03) and rs731236 (dominant model: P = 0.04; recessive model: P = 0.02; allele model: P = 0.01) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rs1544410 (dominant and allele models) and rs731236 (dominant, recessive, and allele models) variants were both significantly associated with TB in South Asians. When we stratified data by type of disease, positive results were detected for rs7975232 variant in EPTB (dominant, recessive, over-dominant, and allele models) subgroup, and for rs2228570 variant in PTB (dominant, recessive, and allele models) and EPTB (dominant, recessive, over-dominant, and allele models) subgroups. Our meta-analysis supported that rs7975232, rs1544410, rs2228570, and rs731236 variants might serve as genetic biomarkers of certain types of TB.

Variations of Serum Oxidative Stress Biomarkers under First-Line Antituberculosis Treatment: A Pilot Study

“…Although, within the granuloma, immune cells interact and trigger immune responses in order to control TB, macrophages can undergo respiratory burst, generating oxidative stress and initiating active pulmonary TB [ 4 , 7 , 8 ]. Bacilli release and infection progression are consequences of lipid peroxidation, parenchymal tissue destruction, and insufficient antioxidant defence mechanisms [ 3 , 9 , 10 ]. The higher the bacterial load, the more advanced will be the necrosis; therefore, an immunological fight between M.tb.…”

“…The higher the bacterial load, the more advanced will be the necrosis; therefore, an immunological fight between M.tb. and the individual will establish disease consequences [ 3 , 9 , 11 , 12 ].…”

Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population

“…Haplotype analysis was performed for five polymorphisms in the TLR1-TLR6-TLR10 gene cluster, two 25 Xu and Shen 2019, 26 Chen et al polymorphisms in the TLR2 gene and three VDR gene polymorphisms using Haploview version 4.2 software. 34 SNPs TLR1 rs4833095, TLR2 rs3804099, TLR6 rs5743810, and TLR10 rs11466657 were taken from the previous study conducted on the same cohort of TB patients and healthy controls.…”

Vitamin D In Gambian Children With Discordant Tuberculosis Infection Status Despite Matched TB Exposure: A Case Control Study

“…Vitamin D de ciency has been associated with increased risk of tuberculosis (TB) disease 1 , and infection 2 . Host vitamin D Receptor (VDR) genetic variants are also associated with risk of TB disease 3 . Although vitamin D supplementation has recently been shown not to prevent latent TB infection in Mongolian children 4 , vitamin D levels are in uenced by genetics, cultural factors, diet and latitude, making it unclear how these ndings may relate to tropical African settings 5 .…”