Associations between Weight in Early Adulthood, Change in Weight, and Breast Cancer Risk in Postmenopausal Women

Krishnan, Kavitha; Bassett, Julie K.; MacInnis, Robert J.; English, Dallas R.; Hopper, John L.; McLean, Catriona; Giles, Graham G.; Baglietto, Laura

doi:10.1158/1055-9965.epi-13-0136

Cited by 43 publications

(40 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two cohort studies [20,25] reported only weak, non-significant inverse associations, consistent with our findings. As noted for premenopausal BC, previous publications differed by their study designs, study populations, exposure measurements (all self-reported), number of BC cases (ranging from 354 [18] to 7582 [15]), reference categories and model adjustments.…”

Section: Adolescent Overweight and Obesitypostmenopausal Bcsupporting

confidence: 92%

“…An Australian cohort indicated that self-reported weight and BMI at ages 18-21 years were not associated with any type of BC [20], whereas a US case-control study reported an inverse relationship of self-reported BMI at age 20 with pre-and postmenopausal BC [21]. These inconsistencies might be partially attributed to misreporting of adolescent BMI.…”

Section: Introductionmentioning

confidence: 98%

“…Two later studies were inconsistent [20,21]. An Australian cohort indicated that self-reported weight and BMI at ages 18-21 years were not associated with any type of BC [20], whereas a US case-control study reported an inverse relationship of self-reported BMI at age 20 with pre-and postmenopausal BC [21].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Measured adolescent body mass index and adult breast cancer in a cohort of 951,480 women

Boker

Levine

Derazne

et al. 2016

Breast Cancer Res Treat

View full text Add to dashboard Cite

Body mass index (BMI) in adolescence, studied predominantly as a self-reported risk factor for breast cancer (BC), may have been subjected to recall bias. We examined the association between measured BMI in adolescence and the incidence of BC by menopausal status. 951,480 Jewish Israeli females aged 16-19 who underwent anthropometric measurements in 1967-2011 were followed up to 31.12.2012 for BC incidence. Cox proportional hazards models assessed the association between adolescent BMI (as age-specific CDC percentiles) and time to BC diagnosis, adjusting for sociodemographic covariates. The analysis was also subdivided by age at diagnosis. 9619 BC cases diagnosed during 18,078,941 person-years of follow-up were included in multivariable analyses: 4901 premenopausal, 3809 perimenopausal, and 909 postmenopausal. Compared with 'healthy' BMI (5th-<85th percentiles) and adjusted for country of origin, education, and height, adolescent BMI was largely negatively associated with BC: hazard ratio (HR) = 1.057 (95 % confidence interval (CI) 0.955-1.169, p = 0.286) in underweight (<5th percentile); HR = 0.918 (95 % CI 0.849-0.993, p = 0.032) in overweight (85th-<95th percentiles); and HR = 0.682 (95 % CI 0.552-0.843, p = 0.00004) in obese (≥95th percentile) women. In premenopausal, but not peri- and postmenopausal BC, associations were statistically significant; underweight was associated with increased risk of premenopausal BC (HR = 1.15, 95 % CI 1.01-1.31, p = 0.037), and overweight and obesity with significantly lower risk. Adolescent thinness was associated with increased risk for early BC. Overweight and obesity were protectively associated with premenopausal but not postmenopausal BC. The lack of an association of adolescent overweight/obesity with increased peri- and postmenopausal BC suggests a causal role for adult weight gain.

show abstract

Section: Adolescent Overweight and Obesitypostmenopausal Bcsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Measured adolescent body mass index and adult breast cancer in a cohort of 951,480 women

Boker

Levine

Derazne

et al. 2016

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…1,3,12,16,17,20 The effect of weight change has been proposed to be modified by BMI 15 and the use of postmenopausal hormone replacement therapy (HRT). 4,[6][7][8]11 Studies suggest that the relationship is more pronounced or only present in leaner women and non-HRT users.…”

Section: ) the Results For Weight Gain In Middle Adulthoodmentioning

confidence: 99%

“…Based on the results of cohort [1][2][3][4][5][6][7][8][9][10][11] and case-control studies, [12][13][14][15][16][17] the World Cancer Research Fund states that longterm adult weight gain (i.e., recalled weight gain since age 20) increases the risk of postmenopausal breast cancer and grades this relation as "probable". 18 Most studies investigated the association between longterm weight gain and breast cancer risk without a focus on a particular period in life.…”

mentioning

confidence: 99%

Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study

et al. 2014

View full text Add to dashboard Cite

Long‐term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40–50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow‐up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (−0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow‐up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83–4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3: 1.09, 95% CI: 1.01−1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3: 1.37, 95% CI: 1.02−1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.

show abstract

Effects of a High vs Moderate Volume of Aerobic Exercise on Adiposity Outcomes in Postmenopausal Women

et al. 2015

View full text Add to dashboard Cite

show abstract

Associations between Weight in Early Adulthood, Change in Weight, and Breast Cancer Risk in Postmenopausal Women

Cited by 43 publications

References 40 publications

Measured adolescent body mass index and adult breast cancer in a cohort of 951,480 women

Measured adolescent body mass index and adult breast cancer in a cohort of 951,480 women

Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study

Effects of a High vs Moderate Volume of Aerobic Exercise on Adiposity Outcomes in Postmenopausal Women

Contact Info

Product

Resources

About