“…However, the Violante et al proportion of cases attributable to these factors is probably limited as they are rare (eg, systemic amyloidosis, sarcoidosis) or only weakly associated with CTS (eg, diabetes, hypothyroidism) (13)(14)(15)(16). During the eighties, a landmark study posited an association between fast and forceful manual work and CTS (17): since then, the issue of occupationally induced CTS has been the subject of a number of epidemiological studies, although the majority of them were cross-sectional in design (18). Recently, two large longitudinal studies on CTS and fast and forceful manual work were published, from Italy (19) and the USA (20).…”