Associations of a polymorphism in the intercellular adhesion molecule-1 (ICAM1) gene and ICAM1 serum levels with migraine in a Chinese Han population

He, Qin; Lin, Xiang; Wang, Fengzhi; Xu, Jialiang; Ren, Zhanxiu; Chen, Wei; Xing, Xuesha

doi:10.1016/j.jns.2014.07.030

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…In addition to its association with sICAM1 levels, the ICAM1 SNP rs5498 has been shown to associate with a plethora of diseases in Asians including diabetic microvascular complications [37], proliferative diabetic retinopathy [38], oral carcinogenesis [39], migraine [40], and coronary atherosclerosis [41]. Because rs5498 encodes a lysine-to-glutamic acid mutation at position 469 (K469E) which alters the electrostatic property of the binding site for ICAM1’s ligand LFA-1 [42], it is likely that changes in ICAM1’s affinity to LFA-1 contribute to the inflammation-related diseases.…”

Section: Discussionmentioning

confidence: 99%

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Teng

et al. 2017

PLoS ONE

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Intercellular adhesion molecule–1 (ICAM1) is crucial to the development and progression of atherosclerosis. Recent genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) in two of the nuclear factor-κB (NF-κB) pathway genes, NFKBIK and RELA, are associated with soluble ICAM1 (sICAM1) levels. However, neither of these two gene variants is found in the Asian populations. This study aimed to elucidate whether other candidate gene variants involved in the NF-κB pathway may be associated with sICAM1 levels in Taiwanese. After excluding carriers of the ICAM1 rs5491-T allele, three SNPs in the ICAM1 gene and eight SNPs in six of the NF-κB pathway genes (NFKB1, PDCD11, TNFAIP3, NKAPL, IKBKE, and PRKCB) were analyzed for their association with sICAM1 levels in 480 individuals. Our data showed that two SNPs, rs5498 of ICAM1 and rs1635 of NKAPL, were significantly associated with sICAM1 levels (P = 0.002 and 0.004, respectively) in the Taiwanese population. Using a multivariate analysis, rs5498 and rs1635 as well as the previously reported ABO genotypes and rs12051272 of the CDH13 gene were independently associated with sICAM1 levels (P = 0.001, 0.001, 0.006 and 0.031, respectively). An analysis with combined risk alleles of four candidate SNPs in the ICAM1, NKAPL, ABO, and CDH13 genes showed an increase in sICAM1 levels with added numbers of risk alleles and weighted genetic risk score. Our findings thus expanded the repertoire of gene variants responsible for the regulation of sICAM1 levels in the Asian populations.

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Section: Discussionmentioning

confidence: 99%

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Teng

et al. 2017

PLoS ONE

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“…A third study by He et al 50 reported significantly higher mean ICAM-1 serum concentrations in migraine patients than controls (4372±78 vs 679±21, P < 0.01). They also reported that patients with the E-allele had higher ICAM-1 concentrations than K-allele carriers of the ICAM1 K469E polymorphism (5493±137 vs 3971±80, P < 0.01) but did not provide the genotype-specific ICAM-1 concentrations in controls (which may reflect their nonsignificant differences).…”

Section: Discussionmentioning

confidence: 87%

“…Published examples of gene-disease and gene-environment interactions were identified through keyword search on PubMed. Data from these studies were reanalyzed using genotype-specific means or medians presented in the original articles [44][45][46][47][48][49][50][51][52][53][54][55][56] or by extracting these values from published graphs [57][58][59][60][61][62] using the Microsoft PowerPoint formatting palette as previously described. 24 Specifically, histograms were created that display a precision medicine perspective of genotype-specific patient-control differences or treatment effects.…”

Section: Statisticsmentioning

confidence: 99%

Quantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease

Williams¹

2022

JIR

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Purpose: Heritability (h 2 , the proportion of the phenotypic variance attributable to additive genetic effects) is traditionally assumed to be constant throughout the distribution of the phenotype. However, the heritabilities of circulating C-reactive protein, interleukin-6, plasminogen activator inhibitor type-1 (PAI-1), and monocyte chemoattractant protein-1 (MCP-1) concentrations depend upon whether the phenotype is high or low relative to their distributions (quantile-dependent expressivity), which may account for apparent gene-environment interactions. Whether the heritabilities of other inflammatory biomarkers linked to cardiovascular disease are quantile-dependent remain to be determined. Patients and Methods: Quantile-specific offspring-parent (β OP ) and full-sib regression slopes (β FS ) were estimated by applying quantile regression to the age-and sex-adjusted phenotypes of families surveyed as part of the Framingham Heart Study. Quantile-specific heritabilities were calculated as: h 2 =2β OP /(1+r spouse ) and h 2 ={(1+8r spouse β FS ) 0.5 -1}/(2r spouse ). Results: Heritability (h 2 ± SE) of lipoprotein-associated phospholipase A2 (Lp-PLA 2 ) mass concentrations increased from 0.11 ± 0.03 at the 10 th percentile, 0.08 ± 0.03 at the 25 th , 0.12 ± 0.03 at the 50 th , 0.20 ± 0.04 at the 75 th , and 0.26 ± 0.06 at the 90 th percentile, or 0.0023 ± 0.0006 per each one-percent increase in the phenotype distribution (P linear trend = 0.0004). Similarly, h 2 increased 0.0029 ± 0.0011 (P linear trend = 0.01) for sP-selectin, 0.0032 ± 0.0009 (P linear trend = 0.0001) for soluble intercellular adhesion molecule 1 (sICAM-1), and 0.0026 ± 0.0006 for tumor necrosis factor receptor 2 (TNFR2) (P linear trend = 5.0 × 10 −6 ) per each one-percent increase in their distributions when estimated from β OP . Osteoprotegerin and soluble ST2 heritability also increased significantly with increasing percentiles of their distributions when estimated from β FS . Lp-PLA 2 activity, CD40 ligand, TNFα, interleukin-18, and myeloperoxidase heritability showed no significant quantiledependence. Conclusion:The heritabilities of circulating Lp-PLA 2 -mass, sP-selectin, sICAM-1, TNFR2, osteoprotegerin and soluble ST2 concentrations are quantile-dependent, which may contribute to purported genetic modulations of: 1) sP-selectin's relationships to venous thrombosis, pulmonary hypertension, type 2 diabetes and atorvastatin treatment; 2) sICAM-I's relationships to brain abscess and atorvastatin treatment; and 3) Lp-PLA 2 's relationships to myocardial infarction and preeclampsia.

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“…There are several points that worth noting about this meta‐analysis. First, the rs5498 polymorphism causes an amino acid change from glutamic acid (E) to lysine (K), which is proved to be associated with alteration in protein structure and binding affinity of ICAM‐1 protein (He et al, ; Mohamed et al, ). Thus, it is possible that rs5498 polymorphism may impact biological function of ICAM‐1, give rise to the development of over‐activated inflammatory reactions, and ultimately influence individual susceptibility to IS.…”

Section: Discussionmentioning

confidence: 99%

Associations of intercellular adhesion molecule‐1 rs5498 polymorphism with ischemic stroke: A meta‐analysis

Gao

Zhang²

2019

Molec Gen & Gen Med

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Background Recently, associations between intercellular adhesion molecule‐1 (ICAM‐1) rs5498 polymorphism and ischemic stroke (IS) were investigated by several pilot studies, but with inconsistent results. In this study, a meta‐analysis was performed to better assess the relationship between ICAM‐1rs5498 polymorphism and IS. Methods PubMed, Medline, Embase, and CNKI were searched for eligible studies. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate associations between ICAM‐1 rs5498 polymorphism and IS. Results Totally 16 studies with 2,596 cases and 11,800 controls were analyzed. A significant association with IS was observed for rs5498 polymorphism in GG versus AA + AG (recessive model, p = 0.009, OR = 1.62, 95% CI 1.13–2.32, I2 = 76%) in overall population. Further subgroup analyses showed that rs5498 polymorphism was significantly associated with IS in Caucasians in AA versus AG + GG (dominant model, p = 0.03, OR = 0.52, 95% CI 0.29–0.95, I2 = 72%), GG versus AA + AG (recessive model, p < 0.0001, OR = 2.98, 95% CI 2.05–4.31, I2 = 19%), and A versus G (allele model, p = 0.005, OR = 0.50, 95% CI 0.31–0.81, I2 = 81%). However, no any positive findings were detected for Asians. Conclusions Our findings indicated that rs5498 polymorphism was significantly associated with individual susceptibility to IS in Caucasians, but not in Asians.

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Associations of a polymorphism in the intercellular adhesion molecule-1 (ICAM1) gene and ICAM1 serum levels with migraine in a Chinese Han population

Cited by 13 publications

References 31 publications

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese

Quantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease

Associations of intercellular adhesion molecule‐1 rs5498 polymorphism with ischemic stroke: A meta‐analysis

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