Associations of adenovirus-reactive immunoglobulins with atrial fibrillation and body mass index

Abstract

Adenovirus (AdV) has been suggested to be involved in pathogenesis of atrial fibrillation (AF). We aimed to evaluate an association between AdV-specific immunoglobulins G in the serum (AdV-IgG) and AF. The present case-control study comprised two cohorts, including cohort 1 of patients with AF and cohort 2 of asymptomatic subjects. Initially, two groups, MA and MB, were selected from the cohorts 1 and 2, respectively, for serum proteome profiling using an antibody microarray to identify possible relevant protein targets. The data of microarray analysis indicated a possible overall increase in the total adenovirus signals in the group MA vs. group MB, suggesting potential relevance of adenoviral infection to AF. Then, the groups A (with AF) and B (control) were selected from the cohorts 1 and 2, respectively, to assay the presence and levels of AdV-IgG- by ELSA. The prevalence of AdV-IgG-positive status demonstrated a 2-fold increase in the group A (AF) compared with that in the group B (asymptomatic subjects); odds ratio 2.06 (95%CI: 1.11–3.84; P = 0.02). The prevalence of obesity demonstrated an approximately 3-fold increase in AdV-IgG-positive patients of the group A compared with that in AdV-IgG-negative patients of the same group A (odds ratio 2.7; 95% CI: 1.02–7.1; P = 0.04). Thus, AdV-IgG-positive reactivity was independently associated with AF, and AF was independently associated with BMI, indicating that adenoviral infection may be a possible etiological factor for AF.

Atrial fibrillation recurrence after catheter ablation is associated with RAD51 and p63 proteins

“…A total of 192 patients completed the one-year follow-up period. Clinical and demographic characteristics of the total cohort have been described previously [ 15 ] and are shown in Table 1 . A history of AF was 4.0 ± 2.7 years, and the mean age at the AF onset was 53.24 ± 10.55 years.…”

“…Our previous study profiled the proteins in the serum samples using the antibody microarray technology to discriminate patients with AF from normal subjects [ 15 ] and patients with coronary stenosis from patients with intact coronary vessels, and differential proteins were subsequently verified using an in-house ELISA [ 14 ].…”

“…Inflammation contributes to AF, and we have previously shown that the presence of anti-adenoviral immunoglobulins is associated with fibrillation and adenoviral infection is one of the possible etiological factors for AF [ 15 ]. Moreover, AF recurrence triggers in non-pulmonary veins are highly prevalent in HIV (human immunodeficiency viruses)-positive AF patients.…”

Effects of COVID-19 Infection in Healthy Subjects on Cardiac Function and Biomarkers of Oxygen Transport, Blood Coagulation and Inflammation

“…Information on healthy subjects with COVID-19 infection in anamnesis is very scarce. We have previously demonstrated that adenovirus infection may be an etiological factor of atrial fibrillation [ 5 ]. Thus, a viral infection may have harmful effects on cardiac function due to the mechanisms related to transcriptional and posttranslational modifications that disrupt the gap junctions, influence immune response, or mediate the development of cardiomyopathy during an active infection [ 6 ].…”