Associations of Age and Birth Cohort with Total and Specific IgE Antibody Levels

Tsukioka, Kazuharu; Toyabe, Shin-ichi; Akazawa, Kohei

doi:10.3109/02770903.2011.558152

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Age‐related alterations in the serum IgE levels have been the subject of disagreement. While most of the previous studies demonstrate a decrease in the levels of IgE in elderly both in allergic and healthy individuals, others do not indicate a significant change . We found that Indians showed a negative correlation between age and IgE levels (for Dermatophagoides ), while the correlations in other races was insignificant.…”

Section: Discussioncontrasting

confidence: 63%

Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia

Amini

Abdullah

Seng

et al. 2016

Int Forum Allergy Rhinol

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Clinical parameters in AR may be influenced by race. Symptoms were most severe among Malays but did not correlate with other variables examined. Although Indian ethnicity did not impact disease severity, duration of concurrent allergies and mite-polysensitivity was associated with more severe disease. Age, duration of disease, and sIgE levels may be useful indicators of disease severity in Chinese.

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Section: Discussioncontrasting

confidence: 63%

Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia

Amini

Abdullah

Seng

et al. 2016

Int Forum Allergy Rhinol

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“…Perzanowski and colleagues (2016) showed that children diagnosed with asthma after the age of 12 tended to be less sensitized to mammalian dog dander and had lower IgE levels than children diagnosed before the age of 12 31 . Considering the increasing prevalence of dog ownership over time, a cohort effect could contribute to this difference 47 . Therefore, age might also play a key role in the sensitization profiles of dog allergen components.…”

Section: Discussionmentioning

confidence: 99%

“… 31 Considering the increasing prevalence of dog ownership over time, a cohort effect could contribute to this difference. 47 Therefore, age might also play a key role in the sensitization profiles of dog allergen components.…”

Section: Discussionmentioning

confidence: 99%

Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Ermis

Borres

Basna

et al. 2022

Clin Experimental Allergy

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Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a populationbased and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein).Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma.Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and | ME THODS | Study participantsThe study data were derived from an ongoing population-based longitudinal study, the West Sweden Asthma Study (WSAS). Details of the study procedures have been described elsewhere. 25,26 We sent out 30,000 postal questionnaires to randomly selected 16-75-year-old adults living in the Västra Götaland region of Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion:Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization. K E Y W O R D Scomponent resolved diagnostics, dog allergy, dog dander sensitization, dog molecular allergen components, furry animal allergy, Can f 1, Can f 5 Key Message• Can f 1 (43%) and Can f 5 (33%) were the most commonly sensitized single components.

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Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents

Pierotti

Aranda

Cocco

et al. 2020

Allergologia et Immunopathologia

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Associations of Age and Birth Cohort with Total and Specific IgE Antibody Levels

Abstract: The associations of total and specific IgE levels with age and birth cohort were different. Thus, in comparing the results of IgE antibody testing done in different years, even for patients of the same age, the possibility of a birth cohort effect on IgE levels should be considered.

Cited by 3 publications

References 27 publications

Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia

Ethnicity influences disease characteristics and symptom severity in allergic rhinitis patients in Malaysia

Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Phadiatop, Phadiatop Infant and total IgE evaluated in allergic Brazilian children and adolescents

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