Associations of ambient air pollution with overnight changes in body composition and sleep-related parameters

Tùng, Nguyễn Thanh; Lee, Yueh Lun; Lin, Shang Yang; Wu, Chih Da; Dung, Hoang Ba; Thuy, Tran Phan Chung; Kuan, Yi Chun; Tsai, Chao-Ming; Lo, Chen Chen; Lo, Kang; Ho, Kin Fai; Liu, Wen‐Te; Chuang, Hsiao Chi

doi:10.1016/j.scitotenv.2021.148265

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…We observed that air pollution was associated with disruption of sleep quality, in terms of arousal and the sleep cycle. Similar results were observed in our previous reports, indicating that air pollution exposure (i.e., PM 2.5 and NO 2 ) was associated with an increase in arousal (Lo et al, 2021;Tung et al, 2021b). The increased risk of arousal events by air pollution may be associated with structural changes and edema due to in ammation in upper airway tissues (Billings et (Weinreich et al, 2015).…”

Section: Discussionsupporting

confidence: 88%

“…A previous report showed that PM 2.5 was associated with an increase in the N1 stage in OSA patients(Lo et al, 2021). Also, PM 2.5 and NO 2 were associated with an increase in the N1 stage, whereas a decrease in N2 by NO 2 and a decrease in N3 by PM 2.5 and NO 2 were identi ed(Tung et al, 2021b). Together, these results suggest that air pollution disrupts the sleep cycle by increasing light sleep during sleep time.…”

supporting

confidence: 54%

“…One study estimated levels of O 3 , NO 2 , and PM 2.5 to be 24.86 ppb, 21.25 ppb, and 22.13 µg/m 3 , respectively (Zou et al, 2021). Also, a previous report showed that 1-year average concentrations of O 3 , NO 2 , and PM 2.5 were 27.91 ppb, 18.43 ppb, and 18.44 µg/m 3 , respectively (Tung et al, 2021c). Levels of O 3 and NO 2 , in this study were relatively lower compared to World Health Organization (WHO) air quality guidelines (Organization, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The REM stage is active sleep in which dreams occur, which bene ts memory and learning (Shatzmiller et al, 2010). Our previous reports showed that air pollution was associated with disruption of the sleep cycle in obstructive sleep apnea (OSA) patients (Lo et al, 2021;Tung et al, 2021b). For example, interquartile range (IQR) increases in 1-month particulate matter with an aerodynamic diameter of <2.5 µm (PM 2.5 ) and carbon monoxide (CO) levels were associated with a 6.2% (95% con dence interval (CI): 6.1%~6.3%) increase in the N1 stage and 2.0% (95% CI: -3.8%~-0.1%) decrease in the N2 stage.…”

Section: Introductionmentioning

confidence: 99%

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Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults

Liu

et al. 2022

Environ Sci Pollut Res

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The effects of air pollution on sleep and dementia remain unclear. The objective of this study was to investigate the effects of air pollution on cognitive function as mediated by the sleep cycle. A crosssectional study design was conducted to recruit 4866 subjects on which PSG had been performed. Fifty of them were further given a cognitive function evaluation by the MMSE and CASI as well as brain images by CT and MRI. Associations of 1-year air pollution parameters with sleep parameters, cognitive function, and brain structure were examined. We observed that O 3 was associated with a decrease in arousal, an increase in the N1 stage, and a decrease in the N2 stage of sleep. NO 2 was associated with an increase in the N1 stage, a decrease in the N2 stage, and an increase in REM. PM 2.5 was associated with a decrease in the N1 stage, increases in the N2 and N3 stages, and a decrease in REM. The N1 and N2 stages were associated with cognitive decline, but REM was associated with an increase in cognitive function. The N1 stage was a mediator of the effects of PM 2.5 on the concentration domain of the MMSE. O 3 was associated with an increase in the pars orbitalis volume of the left brain. NO 2 was associated with increases in the rostral middle frontal volume, supramarginal gyrus volume, and transverse temporal volume of the left brain, and the pars opercularis volume of the right brain. PM 2.5 was associated with increases in the pars triangularis volume of the left brain and the fusiform thickness of the right brain. In conclusion, we observed that air pollution was associated with cognitive decline by mediating effects on the sleep cycle with changes in the brain structure in controlling executive, learning, and language functions in adults. Capsule Of Main FindingThe signi cance and novelty of this study was that air pollution was associated with cognitive decline by mediating effects on the sleep cycle with changes in brain structure in adults, thereby could increase the risks of dementia.

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Section: Discussionsupporting

confidence: 88%

supporting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults

Liu

et al. 2022

Environ Sci Pollut Res

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“…Another study in Taiwan captured 85% of annual PM 2.5 variation by using this method (10). Utilizing estimates from the hybrid kriging/LUR, our previous study showed that 0.99 µg/m 3 increase in PM 2.5 resulted in 0.011 kg increase in right arm fat mass, whereas 2.45 ppb increase in NO 2 resulted in 0.181 kg decrease in muscle mass (p < 0.05) (11).…”

Section: Introductionmentioning

confidence: 99%

Association Between Air Pollution and Lung Lobar Emphysema in COPD

Tùng

et al. 2021

Front. Med.

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The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of particulate matter <2.5 μm in aerodynamic diameters (PM2.5) (≤2.5 μm), nitrogen dioxide (NO2), and ozone (O3) level of exposure with the presence of emphysema in 86 patients with chronic obstructive pulmonary disease (COPD). Exposure to the air pollution estimated using the land-use regression model was associated with lung function, BODE (a body mass index, degree of obstruction, dyspnea severity, and exercise capacity index) quartiles, and emphysema measured as low-attenuation areas on high-resolution CT (HR-CT) lung scans. Using paraseptal emphysema as the reference group, we observed that a 1 ppb increase in O3 was associated with a 1.798-fold increased crude odds ratio of panlobular emphysema (p < 0.05). We observed that PM2.5 was associated with BODE quartiles, modified Medical Research Council (mMRC) dyspnea score, and exercise capacity (all p < 0.05). We found that PM2.5, NO2, and O3 were associated with an increased degree of upper lobe emphysema and lower lobe emphysema (all p < 0.05). Furthermore, we observed that an increase in PM2.5, NO2, and O3 was associated with greater increases in upper lobe emphysema than in lower lobe emphysema. In conclusion, exposure to O3 can be associated with a higher risk of panlobular emphysema than paraseptal emphysema in patients with COPD. Emphysema severity in lung lobes, especially the upper lobes, may be linked to air pollution exposure in COPD.

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Associations of overnight changes in body composition with positional obstructive sleep apnea

et al. 2022

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Associations of ambient air pollution with overnight changes in body composition and sleep-related parameters

Cited by 16 publications

References 41 publications

Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults

Air pollution associated with cognitive decline by the mediating effects of sleep cycle disruption and changes in brain structure in adults

Association Between Air Pollution and Lung Lobar Emphysema in COPD

Associations of overnight changes in body composition with positional obstructive sleep apnea

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