Associations of Asthma and Asthma Control With Atrial Fibrillation Risk

Cepelis, Aivaras; Brumpton, Ben; Malmo, Vegard; Laugsand, Lars E.; Loennechen, Jan Pål; Ellekjær, Hanne; Langhammer, Arnulf; Janszky, Imre; Strand, Linn Beate

doi:10.1001/jamacardio.2018.1901

Cited by 45 publications

(33 citation statements)

References 36 publications

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“…Unlikely, a recent study in Korean adults confirmed a significantly higher prevalence of ischemic heart disease (OR = 1.46, 95% CI = 1.25–1.71) in those with asthma, especially, in older patients and// or untreated asthma patients, but stroke was not significantly associated with asthma (OR = 1.17, 95% CI = 0.92–1.48) in adjusted model [ 39 ]. A previous HUNT study concluded that asthma and lack of asthma control were associated with moderately increased risks of atrial fibrillation [ 40 ].…”

Section: Pathogenesis and Pathophysiologymentioning

confidence: 99%

“…As it was stated in the HUNT study, patients with not controlled asthma had an increased risk of stroke (HR = 1.34, 95% CI = 1.03–1.73) compared to controlled asthma (HR = 1.34, 95% CI = 1.03–1.73) [ 3 ]. Moreover, severe asthma was related to a statistically significant difference in CIMT and FIMT ( p = 0.002 and p < 0.001, respectively) [ 27 ] and the highest risk for AF (adjusted HR = 1.74, 95% CI = 1.26–2.42) [ 40 ]. Likewise, patients with severe asthma had increased baPWV and CRP compared to patients with stable asthma and control subjects [ 26 ].…”

Section: Asthma Phenotypes Severity and Comorbiditiesmentioning

confidence: 99%

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Asthma and stroke: a narrative review

Corlăteanu

Stratan

Covanţev

et al. 2021

asthma res and pract

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Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation, bronchial reversible obstruction and hyperresponsiveness to direct or indirect stimuli. It is a severe disease causing approximately half a million deaths every year and thus possessing a significant public health burden. Stroke is the second leading cause of death and a major cause of disability worldwide. Asthma and asthma medications may be a risk factors for developing stroke. Nevertheless, since asthma is associated with a variety of comorbidities, such as cardiovascular, metabolic and respiratory, the increased incidence of stroke in asthma patients may be due to a confounding effect. The purpose of this review is to analyze the complex relationship between asthma and stroke.

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Section: Pathogenesis and Pathophysiologymentioning

confidence: 99%

Section: Asthma Phenotypes Severity and Comorbiditiesmentioning

confidence: 99%

Asthma and stroke: a narrative review

Corlăteanu

Stratan

Covanţev

et al. 2021

asthma res and pract

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“…Studies have indicated that PM activates TRPA1 activity in the respiratory tract, which induces human lung disease ( Deering-Rice et al, 2011 ; Akopian et al, 2016 ). As the level of systemic inflammation increases, the risk of atrial fibrillation in COPD subjects increases ( Grymonprez et al, 2019 ), and there is a negative relationship between the level of asthma control and the increased risk of atrial fibrillation ( Cepelis et al, 2018 ). This seems to suggest that TRPA1 activation indirectly causes arrhythmia.…”

Section: Trpa1 and Common Cardiovascular Diseasesmentioning

confidence: 99%

Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Cardiovascular Diseases

et al. 2020

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Cardiovascular disease is one of the chronic conditions with the highest mortality rate in the world. Underlying conditions such as hypertension, metabolic disorders, and habits like smoking are contributors to the manifestation of cardiovascular diseases. The treatment of cardiovascular diseases is inseparable from the development of drugs. Consequently, this has led to many researchers to focus on the search for effective drug targets. The transient receptor potential channel Ankyrin 1 (TRPA1) subtype is a non-selective cation channel, which belongs to the transient receptor potential (TRP) ion channel. Previous studies have shown that members of the TRP family contribute significantly to cardiovascular disease. However, many researchers have not explored the role of TRPA1 as a potential target for the treatment of cardiovascular diseases. Furthermore, recent studies revealed that TRPA1 is commonly expressed in the vascular endothelium. The endothelium is linked to the causes of some cardiovascular diseases, such as atherosclerosis, myocardial fibrosis, heart failure, and arrhythmia. The activation of TRPA1 has a positive effect on atherosclerosis, but it has a negative effect on other cardiovascular diseases such as myocardial fibrosis and heart failure. This review introduces the structural and functional characteristics of TRPA1 and its importance on vascular physiology and common cardiovascular diseases. Moreover, this review summarizes some evidence that TRPA1 is correlated to cardiovascular disease risk factors.

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“…The connection between BA and supraventricular arrhythmias, including atrial fibrillation (AF), was noted in studies by Warnier et al (18), Goudis et al (19), and Cepelis et al (20). Available data indicate that in the adult population, cardiac arrhythmias are significantly more common in patients with BA than in those without it (13,18,21,22).…”

Section: Introductionmentioning

confidence: 99%

“…Available data indicate that in the adult population, cardiac arrhythmias are significantly more common in patients with BA than in those without it ( 13 , 18 , 21 , 22 ). The results of a Norwegian population study HUNT study, demonstrate that the risks of supraventricular arrhythmias and AF are increased in patients with an uncontrolled BA ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Bronchial Patency and Parameters of ECG Supraventricular Component in Children With Bronchial Asthma

Gordina¹,

Egoshina²,

Eliseeva³

et al. 2020

Front. Pediatr.

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Background: Uncontrolled asthma (BA) can be complicated by cardiac conduction disturbances and arrhythmias. It is typical mainly for adult asthmatics patients. In asthmatics children the effect of bronchoconstriction on cardiac conduction, including the supraventricular component of the ECG, is currently under discussion. The objective of the research is to analyze ECG parameters of the atrial complex and atrioventricular conduction and to assess their relationship with spirometric indicators in children with BA. Methods: Hundred three patients with BA from the age of 6-17 years were examined. The spirometric parameters were evaluated, including the Tiffeneau index (TI): FEV1/FVC (%), according to the level of which the patient groups were distinguished. Group 1 (G1): with TI more than 85%, (n = 15); Group 2 (G2): with TI from 85 to 75%, (n = 40); Group 3 (G3): with TI <75%, (n = 48). The ECG parameters that characterize supraventricular conduction, including the PQ interval (sec) and the sPQ segment (sec), were analyzed. We had calculated relative PQ (rPQ) by the formula rPQ=PQ/PQmed, where PQ is the patient's PQ, PQmed are the median PQ values of healthy children of age selected. Results: The duration of the PQ in groups G1 and G2 was 0.13 (0.11; 0.14) s; and 0.13 (0.12; 0.14) s, respectively, which is statistically significantly less than in patients of groups G3-0.14 (0.13; 0.15] s, p = 0.01. The duration of the sPQ segment in children of groups G1 and G2 was also generally shorter than in patients of groups G3, and amounted, respectively, to 0.05 (0.04; 0.06) s, 0.04 (0.04; 0.05) s, and 0.06 (0.04; 0.07) s, p = 0.02. The rPQ increased progressively as TI decreased and amounted in G1 to 92.9 (85.7; 106.3) %, in G2 100.0 (92.9; 103.0) %, and in G3 104 (100.0; 107.7) %, p = 0.009. A statistically significant negative correlation between IT and PQ-r = −0.23, p = 0.02; with sPQ-r = −0.20, p = 0.045; and with rPQ-r = −0.25, p = 0.01 was revealed. Conclusion: A decrease in TI in asthmatics children is associated with a prolongation of the PQ. This may indicate a slowdown in supraventricular conduction in patients with uncontrolled asthma and, thus, be considered as a risk for the formation of subsequent supraventricular arrhythmias.

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Associations of Asthma and Asthma Control With Atrial Fibrillation Risk

Abstract: Asthma and lack of asthma control were associated with moderately increased risks of AF in a dose-response manner. Further studies are needed to explore the underlying mechanisms and clarify causal pathways between asthma and AF.

Cited by 45 publications

References 36 publications

Asthma and stroke: a narrative review

Asthma and stroke: a narrative review

Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Cardiovascular Diseases

The Relationship Between Bronchial Patency and Parameters of ECG Supraventricular Component in Children With Bronchial Asthma

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