Associations of audiometric hearing and speech-in-noise performance with cognitive decline among older adults: The Baltimore Longitudinal Study of Aging (BLSA)

Jiang, Kening; Armstrong, Nicole; Agrawal, Yuri; Gross, Alden L.; Schrack, Jennifer A.; Lin, Frank R.; Ferrucci, Luigi; Resnick, Susan M.; Deal, Jennifer A.; Powell, Danielle

doi:10.3389/fneur.2022.1029851

Cited by 9 publications

(14 citation statements)

References 32 publications

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“…Lower scores in the present study might be explained by our baseline sample being relatively younger (mean age 51.6 vs. 73.4 25 and 64.1 26 ), since hearing acuity decreases with aging. For mild and moderate to profound HL, previous longitudinal studies generally support our results that objectively measured HL is associated with accelerated cognitive decline in multiple domains 27–31 . Studies examining HL with pure tone audiometry measures generally used a 25 dB threshold to define HL, 27–29 and in the study of Deal et al., 28 only moderate to severe HL (>40 dB) was associated with accelerated cognitive decline.…”

Section: Discussionsupporting

confidence: 83%

“…For mild and moderate to profound HL, previous longitudinal studies generally support our results that objectively measured HL is associated with accelerated cognitive decline in multiple domains. [27][28][29][30][31] Studies examining HL with pure tone audiometry measures generally used a 25 dB threshold to define HL, [27][28][29] and in the study of Deal et al, 28 To our knowledge, incident HL has not been examined before in the context of cognitive change over time. We found that cognitive decline in incident HL was restricted to a change from 6-to 12-year follow-up, without a significant change in the first six years.…”

Section: Discussionmentioning

confidence: 99%

“…For mild and moderate to profound HL, previous longitudinal studies generally support our results that objectively measured HL is associated with accelerated cognitive decline in multiple domains. 27 , 28 , 29 , 30 , 31 Studies examining HL with pure tone audiometry measures generally used a 25 dB threshold to define HL, 27 , 28 , 29 and in the study of Deal et al., 28 only moderate to severe HL (>40 dB) was associated with accelerated cognitive decline. In MAAS, the association between HL and cognitive decline was already present at a 20 dB threshold.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study

Soons,

Deckers,

Tange

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONHearing loss (HL) has been associated with cognitive decline and dementia. We examined the temporal association between prevalent and incident HL and cognitive change.METHODSA total of 1823 participants (24‐82 years) from the Maastricht Aging Study (MAAS) were assessed at baseline, 6 and 12 years, including pure‐tone audiometry. Linear‐mixed models were used to test the association between HL and cognition, adjusted for demographics and other dementia risk factors.RESULTSParticipants with prevalent and incident HL showed a faster decline in verbal memory, information processing speed, and executive function than participants without HL. Decline was steady from baseline to 6 and 12 years for prevalent HL, but time‐delayed from 6 to 12 years for incident HL. Having a hearing aid did not change associations.DISCUSSIONFindings support the notion that HL is a risk factor for cognitive decline independent of other dementia risk factors. Onset of HL preceded onset of cognitive decline.Highlights We examined cognitive change in prevalent and incident hearing loss. Prevalent and incident hearing loss were associated with faster cognitive decline. For prevalent hearing loss, decline was steady from baseline to 6 and 12 years. Onset of hearing loss preceded the onset of cognitive decline. Having a hearing aid did not change the observed associations.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

“…For mild and moderate to profound HL, previous longitudinal studies generally support our results that objectively measured HL is associated with accelerated cognitive decline in multiple domains. 27 , 28 , 29 , 30 , 31 Studies examining HL with pure tone audiometry measures generally used a 25 dB threshold to define HL, 27 , 28 , 29 and in the study of Deal et al., 28 only moderate to severe HL (>40 dB) was associated with accelerated cognitive decline. In MAAS, the association between HL and cognitive decline was already present at a 20 dB threshold.…”

Section: Discussionmentioning

confidence: 99%

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Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study

Soons,

Deckers,

Tange

et al. 2024

Alzheimer's & Dementia

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“…An individual patient's decision to elect observation therapy for VS may be affected by their expected hearing outcomes. A heightened risk of hearing loss may even change the decision calculus altogether given the substantial implications of hearing loss on quality of life and health outcomes (38)(39)(40). Continued evaluation of this relationship may prove useful in providing additional information for clinical decision making.…”

Section: Discussionmentioning

confidence: 99%

Presbycusis and Hearing Preservation in Observed Vestibular Schwannomas

et al. 2023

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Objective We reviewed a cohort of patients with untreated sporadic vestibular schwannoma (VS) and examined the relationship between high-frequency hearing loss (HFHL) in the non-VS ear and long-term hearing outcomes in the VS-affected ear. We hypothesized that the progression of HFHL is associated with accelerated hearing decline in sporadic VS. Study Design Retrospective cohort study. Setting Tertiary center. Patients We studied 102 patients with sporadic VS diagnosed from 1999 to 2015 with ≥5 years of observation (median, 6.92; interquartile range, 5.85–9.29). Sixty-six patients had AAO-HNS class A/B hearing at presentation and were included in analysis. Interventions Audiometry, serial magnetic resonance imaging for observation of VS. Main Outcome Measures Four-frequency pure tone average (PTA) and word recognition scores (WRS) in the VS-affected ear. Decline in high-frequency PTA (average of thresholds at 4000, 6000, and 8,000 Hz) was defined as ≥10 dB during the study period. Decline in WRS was defined as ≥10%. Results Compared with those without, patients with progressive HFHL in the non-VS ear were more likely to experience a decline in WRS in the VS ear (80% vs. 54%, p = 0.031). However, the same group showed no difference (52% vs. 41%, p = 0.40) in decline in PTA of the VS ear. Conclusions Patients with observed VS who experience progressive HFHL in the non-VS ear are more likely to experience significant declines in speech understanding in the VS-affected ear over time. Patients with a history of presbycusis may have an increased risk of losing serviceable hearing because of sporadic VS.

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“…and sensorineural hearing loss, especially if left untreated, appears to further accelerate cognitive decline. Significant associations were found between hearing thresholds (dB PTA) and cognitive performance [Retrospective: ( 6 , 7 , 9 – 14 )]; Prospective: ( 5 , 15 , 20 ); Systematic review: ( 7 , 8 ). 1 Starting with a subclinical hearing loss < 25 dB, audiometric hearing loss (pure tone average) was associated with cognitive decline [Subclinical hearing loss ( 10 ), mild hearing loss ( 11 , 12 ), moderate and severe hearing loss ( 5 , 21 )].…”

Section: Introductionmentioning

confidence: 99%

Hearing loss, depression, and cognition in younger and older adult CI candidates

Huber,

Reuter,

Weitgasser

et al. 2023

Front. Neurol.

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Background and AimHearing loss in old age is associated with cognitive decline and with depression. Our study aimed to investigate the relationship between hearing loss, cognitive decline, and secondary depressive symptoms in a sample of younger and older cochlear implant candidates with profound to severe hearing loss.MethodsThis study is part of a larger cohort study designated to provide information on baseline data before CI. Sixty-one cochlear implant candidates with hearing loss from adulthood onwards (>18 years) were enrolled in this study. All had symmetrical sensorineural hearing loss in both ears (four-frequency hearing threshold difference of no more than 20 dB, PTA). Individuals with primary affective disorders, psychosis, below-average intelligence, poor German language skills, visual impairment, and a medical diagnosis with potential impact on cognition (e.g., neurodegenerative diseases,) were excluded. Four-frequency hearing thresholds (dB, PTA, better ear) were collected. Using the Abbreviated Profile of Hearing Aid Benefit, we assessed subjective hearing in noise. Clinical and subclinical depressive symptoms were assessed with the Beck Depression Inventory (BDI II). Cognitive status was assessed with a neurocognitive test battery.ResultsOur findings revealed a significant negative association between subjective hearing in noise (APHAB subscale “Background Noise”) and BDII. However, we did not observe any link between hearing thresholds, depression, and cognition. Additionally, no differences emerged between younger (25–54 years) and older subjects (55–75 years). Unexpectedly, further unplanned analyses unveiled correlations between subjective hearing in quiet environments (APHAB) and cognitive performance [phonemic fluency (Regensburg Word Fluency), cognitive flexibility (TMTB), and nonverbal episodic memory (Nonverbal Learning Test), as well as subjective hearing of aversive/loud sounds (APHAB)], cognitive performance [semantic word fluency (RWT), and inhibition (Go/Nogo) and depression]. Duration of hearing loss and speech recognition at quiet (Freiburg Monosyllables) were not related to depression and cognitive performance.ConclusionImpact of hearing loss on mood and cognition appears to be independent, suggesting a relationship with distinct aspects of hearing loss. These results underscore the importance of considering not only conventional audiometric measures like hearing thresholds but also variables related to hearing abilities during verbal communication in everyday life, both in quiet and noisy settings.

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Associations of audiometric hearing and speech-in-noise performance with cognitive decline among older adults: The Baltimore Longitudinal Study of Aging (BLSA)

Cited by 9 publications

References 32 publications

Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study

Cognitive change in prevalent and incident hearing loss: The Maastricht Aging Study

Presbycusis and Hearing Preservation in Observed Vestibular Schwannomas

Hearing loss, depression, and cognition in younger and older adult CI candidates

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