Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic

Vítků, Jana; Heráček, Jiří; Sosvorova, Lucie; Hampl, Richard; Chlupáčová, Tereza; Hill, Martin; Sobotka, V.; Bičı́ková, Marie; Stárka, L

doi:10.1016/j.envint.2016.01.021

Cited by 130 publications

(105 citation statements)

References 59 publications

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“…In most studies regarding the effects of endocrine disruptors on steroids, only urinary EDs were correlated with steroid plasma levels. However, recently (Vitku et al, 2016) and colleagues described that elevated seminal levels of BPA were associated with a significant decrease in sperm count, sperm concentration, and morphology. Figure 1 Protein-disulfide isomerase-associated 3 (PDIA3) mRNA levels in swine testis and epididymis (caput, corpus, and cauda).…”

Section: Discussionmentioning

confidence: 99%

GnRH immunization alters the expression and distribution of protein disulfide isomerases in the epididymis

et al. 2016

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SUMMARYHypogonadism is defined as the inadequate gonadal production of testosterone. Low serum testosterone leads to infertility by impairing spermatogenesis and reducing sperm count, however, the impact of hypogonadism in epididymal sperm maturation is poorly understood. From the testis, spermatozoa are transported into the epididymis where they find a specific microenvironment composed of a complex mixture of proteins that facilitate sperm storage and maturation. Inside the epididymal ductule, spermatozoa undergo several changes, resulting in their becoming capable of fertilizing eggs. Protein disulfide isomerases (PDIs) are known to participate in the folding and assembly of secreted proteins in the endoplasmic reticulum. However, little is known about the control and function of PDIs in the testis and epididymis, particularly during male development. The aim of this work was to compare the expression and distribution of PDI and PDIA3 (ERp57) in the testis and epididymis of healthy and GnRH-immunized boars. We detected higher amounts of PDIA3 and PDI in sperm preparations and fluid from the proximal regions of the epididymis of healthy boars. However, we observed an increase in PDIA3 expression in the testis and cauda epididymis in the immunocastrated group. GnRH-immunized boars showed a marked increase in PDI content in cauda spermatozoa and fluid, indicating a possible endocrine dysregulation of PDI. The results of our study suggest that PDIs are associated with epididymal sperm maturation and may be attractive candidates for monitoring male fertility.

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Section: Discussionmentioning

confidence: 99%

GnRH immunization alters the expression and distribution of protein disulfide isomerases in the epididymis

et al. 2016

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“…For instance, Vitku et al . () have found that BPA levels in blood plasma were positively correlated ( P < 0.001) with BPA levels in semen, yet only seminal BPA, not plasma BPA, was negatively associated with different parameters of semen, such as sperm concentration ( r = −0.198; P = 0.009), sperm count ( r = −0.178; P = 0.018) and morphology ( r = −0.160; P = 0.044).…”

Section: Effect Of Bisphenol a On Male Reproductive Processes And Fermentioning

confidence: 99%

“…It appears that although the content of different xenobiotics including BPA in semen can reflect the content in blood, the results of statistical analyses are not always similar. For instance, Vitku et al (2016) have found that BPA levels in blood plasma were positively correlated (P < 0.001) with BPA levels in semen, yet only seminal BPA, not plasma BPA, was negatively associated with different parameters of semen, such as sperm concentration (r = À0.198; P = 0.009), sperm count (r = À0.178; P = 0.018) and morphology (r = À0.160; P = 0.044).…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies

Tomza–Marciniak

Stępkowska

Kuba

et al. 2017

J of Applied Toxicology

118

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As bisphenol A (BPA) is characterized by a pronounced influence on human hormonal regulation, particular attention has been aimed at understanding its role in reproductive processes in males and females, as well as on fetal development. Owing to the increasing number of alarming reports on the negative consequences of the presence of BPA in human surroundings, more and more studies are being undertaken to clarify the negative effects of BPA on human reproductive processes. The aim of this work was to collect and summarize data on the influence of BPA exposure on reproductive health. Based on an analysis of selected publications it was stated that there is strong proof confirming that BPA is an ovarian, uterine and prostate toxicant at a level below the lowest observed adverse effect level (50 mg kg À1 bodyweight) as well as a level below the proposed safe level (4 μg kg À1 bodyweight). It seems there is also reliable evidence in relation to the negative effect of BPA on sperm quality and motility. Limited evidence also pertains to the case of the potential of BPA to affect polycystic ovary syndrome occurrence. Although in epidemiological studies this disease was common, in studies on animal models such results were still not confirmed. No unambiguous results of epidemiological studies and with animal models were obtained in relation to the evaluation of associations between BPA and implantation failure in women, evaluation of associations between BPA and sexual dysfunction in men, and impact of BPA on birth rate, birth weight and length of gestation.

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“…It was also observed that increased BPA concentration in urine is also found to be related to greater sperm DNA damage 50 . Viktu et al, observed blood plasma and also found a correlation with BPA level in plasma and alteration in sperm parameters 131 . Recently reported that there is an interaction between BPA exposure and obesity on sperm count and sperm concentration as observed in mice confirming the toxic effect of BPA on male reproduction 132,133 .…”

Section: Bpa Induced Oxidative Stress and Generation Of Rosmentioning

confidence: 92%

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2019

IJPSR

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Bisphenol-A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an emerging environmental toxicant with endocrine disrupting properties and toxic effects on living organisms. BPA is ubiquitously present in consumer products current in our daily lives. As it is released from consumer products and deposited in the environment, thus creating the potential for human exposure through oral, inhaled, and dermal routes. BPA exposure might be able to cause oxidative damage by disturbing the balance between reactive oxygen species (ROS) and the antioxidant defense system of eukaryotic cells, resulting in the development of oxidative stress-related diseases. From the available information, it can be inferred that a wide variety of BPA intake through any mode results into a generation of reactive oxygen species (ROS), altering the antioxidant balance of eukaryotic cells, induces mitochondrial dysfunction, and affects cell signaling pathways related to oxidative stress. BPA induced oxidative stress might be able to cause sperm damage, mitochondrial dysfunction, and impairment of the structure and function of spermatozoa resulting in male infertility. Here, a review of the current literature examining literature related to BPA exposure, induction of ROS or oxidative stress and concludes that it alters reproductive system functions through induced oxidative stress pathways and negatively affects the fertility of male and females.

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Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic

Cited by 130 publications

References 59 publications

GnRH immunization alters the expression and distribution of protein disulfide isomerases in the epididymis

GnRH immunization alters the expression and distribution of protein disulfide isomerases in the epididymis

Effect of bisphenol A on reproductive processes: A review of in vitro, in vivo and epidemiological studies

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