Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

Zeng, Hao‐Long; Yang, Qing; Yuan, Peihong; Wang, Xu; Cheng, Liming

doi:10.21203/rs.3.rs-54691/v1

Cited by 8 publications

(10 citation statements)

References 37 publications

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“… Calder, 2020 Calder et al, 2020 Celik et al, 2021 Chaturvedi et al, 2004 Culbertson and Culotta, 2021 de Almeida Brasiel, 2020 de Jesus and de Araú jo Andrade, 2020 Ersö z and Y ı lmaz, 2021 Grzywa-Celiń ska et al, 2020 Hultman and Pollard, 2015 Moghaddam et al, 2020 Muhammad et al, 2021 Rahman and Idid, 2021 Skalny et al, 2020 Vogel-Gonzá lez et al, 2021 Zeng et al, 2021 .…”

Section: Uncited Referencementioning

confidence: 99%

The effects of some essential and toxic metals/metalloids in COVID-19: A review

Domingo

Marquès

2021

Food and Chemical Toxicology

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Thousands of studies have been conducted in order to understand in depth the characteristics of the novel coronavirus SARS-CoV-2, its infectivity and ways of transmission, and very especially everything related to the clinical and severity of the COVID-19, as well as the potential treatments. In this sense, the role that essential and toxic metals/metalloids have in the development and course of this disease is being studied. Metals/metalloids such as arsenic, cadmium, lead, mercury or vanadium, are elements with known toxic effects in mammals, while trace elements such as cobalt, copper, iron, manganese, selenium and zinc are considered essential. Given the importance of metals/metalloids in nutrition and human health, the present review was aimed at assessing the relationship between various essential and toxic metals/metalloids and the health outcomes related with the COVID-19. We are in the position to conclude that particular attention must be paid to the load/levels of essential trace elements in COVID-19 patients, mainly zinc and selenium. On the other hand, the exposure to air pollutants in general, and toxic metal/metalloids in particular, should be avoided as much as possible to reduce the possibilities of viral infections, including SARS-CoV-2.

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Section: Uncited Referencementioning

confidence: 99%

The effects of some essential and toxic metals/metalloids in COVID-19: A review

Domingo

Marquès

2021

Food and Chemical Toxicology

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“…This study identified a link between chronic kidney disease and death. In another study [22], the concentration of magnesium was measured in whole blood samples showing a significantly lower magnesium level in severe than in nonsevere Covid-19 patients. Lastly, in a small cohort study [23], hypermagnesemia prevalence was significantly higher in the ICU group than in the outpatient group.…”

Section: Univariate Analysismentioning

confidence: 99%

“…and the elderly. However, data about the magnesium status during the Covid-19 are scarce [20][21][22][23].…”

mentioning

confidence: 99%

Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors

Quilliot¹,

Bonsack²,

Jaussaud³

et al. 2020

Magnesium Research

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Hypomagnesemia and hypermagnesemia could have serious implications and possibly lead to progress from a mild form to a severe outcome of Covid-19. Susceptibility of subjects with low magnesium status to develop and enhance this infection is possible. There is little data on the magnesium status of patients with Covid-19 with different degrees of severity. This study was conducted to evaluate prevalence of dysmagnesemia in a prospective Covid-19 cohort study according to the severity of the clinical manifestations and to identify factors associated. Serum magnesium was measured in 300 of 549 patients admitted to the hospital due to severe Covid-19. According to the WHO guidelines, patients were classified as moderate, severe, or critical. 48% patients had a magnesemia below 0.75 mmol/L (defined as magnesium deficiency) including 13% with a marked hypomagnesemia (<0.65 mmol/L). 9.6% had values equal to or higher than 0.95 mmol/L. Serum magnesium concentrations were significantly lower in female than in male (0.73 AE 0.12 vs 0.80 AE 0.13 mmol/L), whereas the sex ratio M/F was higher in severe and critical form (p<0.001). In a bivariate analysis, the risk of magnesium deficiency was significantly and negatively associated with infection severity (p<0.001), sex ratio (M/F, p<0.001), oxygenotherapy (p<0.001), stay in critical care unit (p=0.028), and positively with nephropathy (p=0.026). Logistic regression analysis revealed that the strongest predictors of magnesium deficiency were female sex (OR=2.67, p<0.001) and nephropathy (OR=2.12, p=0.032) and after exclusion of sex ratio, the severity of infection (OR=0.46, p=0.04 and OR=0.39 p=0.01), for critical and moderate forms, respectively. This transversal study reveals a high prevalence of hypomagnesemia in hospitalized patients for Covid-19, while high-level serum magnesium concentration was more prevalent in critical form.

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“…Available information suggests that zinc deficiency is associated with increased disease severity of the COVID-19 [5] . In a comprehensive metal(loid)s analysis, compared to the non‐severe COVID‐19 patients, the whole blood chromium, calcium, and copper levels were higher, while the levels of zinc, magnesium, manganese, iron, lead, arsenic, and thallium were lower in the severe patients with COVID-19 [6] . Depending on age and gender, the recommended daily allowance for zinc varies between 2 to 13 mg/day, with the tolerable upper intake level for zinc is set at 40 mg/day by the Institute of Medicine (IOM).…”

Section: Zinc: An Essential Trace Elementmentioning

confidence: 97%

COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?

Razzaque

2021

Computational and Structural Biotechnology Journal

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Coronavirus disease-19 (COVID-19)-induced severe acute respiratory syndrome is a global pandemic. As a preventive measure, human movement is restricted in most of the world. The Centers for Disease Control and Prevention (CDC), the National Institutes of Health (NIH), along with the WHO have laid out some therapeutic guidelines for the infected patients. However, other than handwashing and vigilance surrounding commonly encountered oronasal symptoms and fever, no useful prophylactic measure has yet been established. In a pandemic, the accessibility of a prophylactic biologically active substance is crucial. Ideally, it would be something readily available at a low price to a larger percentage of the population with minimal risk. Studies have demonstrated that zinc may reduce viral replication and increase immune responses. For example, in some studies, zinc supplementation used against the influenza virus has been shown to yield clinical benefits with reduced disease burden. While consuming zinc (within the recommended upper safety limits), as a prophylactic might provide an additional shield against the initiation and progression of COVID-19 would need clinical studies, the potential clearly exists.

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Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

Cited by 8 publications

References 37 publications

The effects of some essential and toxic metals/metalloids in COVID-19: A review

The effects of some essential and toxic metals/metalloids in COVID-19: A review

Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors

COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?

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