Associations of body mass index with meniscal tears

Ford, Gregory M.; Hegmann, Kurt T.; White, George L.; Holmes, Edward B.

doi:10.1016/j.amepre.2005.01.013

Cited by 72 publications

(65 citation statements)

References 34 publications

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“…In the knee, increased BMI is associated with a greater risk for meniscal tears, meniscectomy (3–5), and development of osteoarthritis (OA) (6–8). Meniscectomy, in which the torn fragment of meniscus is resected, is extremely prevalent such that in the US alone 465,000−690,000 partial meniscectomies are performed annually (9, 10).…”

Section: Introductionmentioning

confidence: 99%

Relationship of Gene Expression in the Injured Human Meniscus to Body Mass Index: A Biologic Connection Between Obesity and Osteoarthritis

Farooq

Patra

Sandell

et al. 2014

Arthritis & Rheumatology

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Objective Higher body mass index (BMI) increases the risk of meniscus injury and knee osteoarthritis (OA). However, it is unknown if and how obesity affects meniscus biology. We analyzed transcriptome-wide gene expression profiles of injured human menisci to test the hypothesis that meniscal gene expression signatures relate to patient BMI. Methods Meniscus samples were collected from patients undergoing arthroscopic partial meniscectomy. Transcriptome-wide analysis of gene expression followed by validation of selected transcripts by QuantiGene Plex assay was performed. Correlations of gene expression with BMI and relative fold-changes in three BMI categories [lean (LN; BMI=18.5–24.9 kg/m2), overweight (OW; BMI=25.0−29.9 kg/m2), obese (OB; BMI>30.0 kg/m2)] were analyzed and integrated functional classifications were probed computationally. Results OB/OW comparison resulted in the largest set of differences (565-transcripts) followed by OB/LN (280-transcripts) and OW/LN (125-transcripts) comparisons. Biologic reproducibility was confirmed by cluster analysis of expressed transcripts. Differentially regulated transcripts represented important functional classifications. Transcripts associated with oxygen-transport, calcium-ion-binding, and cell-homeostasis were elevated with BMI while those related to extracellular-matrix-deposition, cell-migration, and glucosamine-metabolic-processes were repressed. While these functional classifications may play key roles in cartilage/meniscus homeostasis, failure of extracellular-matrix-deposition and increase in calcium-ion-binding likely contribute to OA development following meniscal injury. Conclusion Our results indicate greater differences in gene expression between OB/OW category rather than OW/LN category. This may indicate that there is a weight-threshold at which injured meniscus responds severely to increased BMI. BMI-related changes in gene expression present a plausible explanation for the role of meniscal injury in OA development among obese patients.

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Section: Introductionmentioning

confidence: 99%

Relationship of Gene Expression in the Injured Human Meniscus to Body Mass Index: A Biologic Connection Between Obesity and Osteoarthritis

Farooq

Patra

Sandell

et al. 2014

Arthritis & Rheumatology

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“…Osteoarthritis is a common condition related to being overweight and obese [16]. A meniscal lesion has not only been associated with the presence of a degenerative knee, but BMI has also been shown as an independent risk factor for the development of meniscal tears [5, 25]. Menisci are believed to transmit more than half the load to the knee joint [25].…”

Section: Discussionmentioning

confidence: 99%

Role of nonoperative treatment in managing degenerative tears of the medial meniscus posterior root

Neogi

Kumar

Rijal

et al. 2013

J Orthopaed Traumatol

100

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BackgroundTears of the medial meniscus posterior root can lead to progressive arthritis, and its management has no consensus. The aim of our study was to evaluate the effect of supervised exercise therapy on patients with medial meniscus posterior root tears.Materials and methodsBetween January 2005 and May 2007, 37 patients with this tear verified by magnetic resonance imaging (MRI) and osteoarthritis grade 1–2 by radiographic examination were treated by a short course of analgesics daily for up to 6 weeks and then as required during follow-up, as well as a 12-week supervised exercise program followed by a home exercise program. Final analysis was performed for 33 patients, average age 55.8 (range 50–62) years and average follow-up of 35 (range 26–49) months. Patients were followed up at 3, 6, and 12 months and yearly thereafter using the Lysholm Knee Scoring Scale, Tegner Activity Scale (TAS), and visual analog scale (VAS). The analysis was performed using one-way analysis of variance (ANOVA) and Pearson’s correlation coefficient to determine the relationship between Lysholm score and body mass index (BMI).ResultsPatients showed an improvement in Lysholm score, TAS, and VAS, which reached maximum in 6 months and later was accompanied by a decline. However, scores at the final follow-up were significantly better than the pretherapy scores. There was also a progression in arthritis as per Kellgren and Lawrence radiographic classification from median 1 preintervention to median 2 at the final follow-up. A correlation between BMI and Lysholm scores was seen (r = 0.47).ConclusionSupervised physical therapy with a short course of analgesics followed by a home-based program results in symptomatic and functional improvement over a short-term follow-up; however, osteoarthritis progression continues and is related to BMI.

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“…12 Although conventional surgical interventions, including meniscectomy and suture fixation, appear to relieve pain symptom in the short term, long-term follow-ups suggest that these treatments are associated with an increased risk of osteoarthritis. [13][14][15] The bottom line is that none of these procedures initiate repair or regeneration of the injured meniscus.…”

Section: Interactions Of Meniscal Cells With Extracellular Matrix Molmentioning

confidence: 98%

Interactions of meniscal cells with extracellular matrix molecules

Tan

Cooper‐White

2011

Cell Adhesion & Migration

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Menisci are one of the most commonly injured parts of the knee. Conventional surgical interventions are often associated with a long-term increased risk of osteoarthritis. Meniscal tissue engineering utilizes natural or synthetic matrices as a scaffold to guide tissue repair or regeneration in three dimensions. Studies have shown that a diverse cellular response can be triggered depending on the composition of the surrounding extracellular matrix (ECM) components. As such, attempts have been made to replace or repair meniscus defects using tissue grafts or reconstituted ECM components prepared from a multitude of tissues. This commentary summarizes the most recent data on the response of meniscal cells to ECM components, both in vivo and in vitro, and focuses on their potential roles in meniscal repair and regeneration. We also discuss our recent investigations into the interactions of meniscal cells and a self assembled biomimetic surface composed of meniscal ECM molecules. The biological effects conferred by the biomimetic surface, in terms of cell adhesion, proliferation, gene expression profiles and matrix synthesis, were evaluated. Finally, some suggested directions for future research in this field are outlined.

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Associations of body mass index with meniscal tears

Cited by 72 publications

References 34 publications

Relationship of Gene Expression in the Injured Human Meniscus to Body Mass Index: A Biologic Connection Between Obesity and Osteoarthritis

Relationship of Gene Expression in the Injured Human Meniscus to Body Mass Index: A Biologic Connection Between Obesity and Osteoarthritis

Role of nonoperative treatment in managing degenerative tears of the medial meniscus posterior root

Interactions of meniscal cells with extracellular matrix molecules

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