Associations of breast milk adiponectin, leptin, insulin and ghrelin with maternal characteristics and early infant growth: a longitudinal study

Yu, Xinting; Rong, Shi Song; Sun, Xiujing; Ding, Guofang; Wan, Weilin; Zou, Liying; Wu, Shaowen; Li, Ming; Wang, Danhua

doi:10.1017/s0007114518002933

Cited by 57 publications

(106 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is agreement in the Ghrelin data: Ghrelin levels were found to be lower in colostrum and mature milk, but no differences were observed in transitional milk [17,19,20].…”

Section: Hormonessupporting

confidence: 61%

“…Another two studies analyzed the HM samples with an ELISA test, but found opposite results. Yu et al showed an increase of insulin levels, not only in mature milk, but also in colostrum in women with GDM, especially in those receiving insulin injections [17]. Nunes et al did not find differences in both types of milk [18].…”

Section: Hormonesmentioning

confidence: 96%

“…Adiponectin levels showed similar conflicting results: two studies demonstrated that GDM was not associated with variations of adiponectin levels in HM, whereas Yu et al observed that women with GDM had lower concentrations of adiponectin in colostrum on day 3 and mature milk on day 90, but no differences on day 42 [16][17][18].…”

Section: Hormonesmentioning

confidence: 99%

See 2 more Smart Citations

Influence of Diabetes during Pregnancy on Human Milk Composition

Peila

Gazzolo²,

Bertino

et al. 2020

Nutrients

View full text Add to dashboard Cite

Human milk (HM) is a unique nourishment believed to contain biological factors contributing to both short and long-term benefits. Considering that a mother’s own milk is often considered the first choice for nutrition of neonates, an aspect of increased interest is the possible effect of diabetes on the mammary gland and therefore on breast milk composition. This article aims to review the published literature on this topic, and to offer additional insights on the role of this disease on the composition of HM. This review was performed by searching the MEDLINE, EMBASE, CINHAL and Cochrane Library databases. A total of 50 articles were selected, focused specifically on one of the two types of diabetes: gestational diabetes mellitus (21 studies) and insulin-dependent diabetes mellitus (8 studies). Overall, the findings from the literature suggest that diabetes can alter the composition of HM. Nevertheless, the studies in this field are scarce, and the related protocols present some limitations, e.g., evaluating the variability of just a few specific milk biochemical markers in association with this syndrome.

show abstract

“…There is agreement in the Ghrelin data: Ghrelin levels were found to be lower in colostrum and mature milk, but no differences were observed in transitional milk [17,19,20].…”

Section: Hormonessupporting

confidence: 61%

Section: Hormonesmentioning

confidence: 96%

See 1 more Smart Citation

Influence of Diabetes during Pregnancy on Human Milk Composition

Peila

Gazzolo²,

Bertino

et al. 2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…As variations in circulating adipokines (18), IGF-1 and cGP (19,20) have been linked to various health and disease outcomes and significant differences in HM hormone concentrations have been described across mother-infant dyads (21)(22)(23), research has focused on associations between hormone concentrations in HM and infant growth outcomes (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). However, while some studies suggest that individual hormonal signatures in HM are associated with different infant growth trajectories, the findings of research in this area remains conflicting (37).…”

Section: Introductionmentioning

confidence: 99%

Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years

et al. 2020

View full text Add to dashboard Cite

Background: Human milk bioactives may play a role in infant health and development. Although the variability in their concentrations in milk is well-established, the impact of differential milk profiles on infant growth outcomes remains unclear. Thus, the aim of the present study was to investigate whether different concentrations of metabolic hormones are associated with different weight and BMI in infants beyond the first year of life. Methods: Milk samples at 2.6 (±0.4) months after birth and anthropometric measures at 13 months, 2, 3, and 5 years were collected as part of the Finnish STEPS cohort study from 501 mothers and the respective 507 infants. Leptin, adiponectin, insulin-like growth factor (IGF)-1 and cyclic glycine-proline (cGP) in milk were analyzed. Multiple regression models and a repeated measures mixed model were used to examine associations between milk hormone concentrations and weight and BMI z-scores across time, at each time-point, and weight gain from birth to each follow-up visit. All models were corrected for birth weight, infant sex, duration of exclusive and total breastfeeding, time of introduction of solid foods and maternal pre-pregnancy BMI. Results: Higher milk IGF-1 was associated with higher weight at 13 months (p = 0.004) but lower weight at 3 (p = 0.011) and 5 years of age (p = 0.049). Higher cGP was associated with lower weight across the 5 years (p = 0.019) but with higher BMI at 5 years (p = 0.021). Leptin and adiponectin did not display associations with infant growth at this time. Sex interactions were also absent. Conclusions: Our results suggest that the interplay between human milk-borne IGF-1 and cGP is similar to that reported in other mammals and may have an important role Galante et al. Breastmilk IGF-1 and Infant Growth in defining infant growth trajectories beyond the first year of life. Further research should explore the determinants and origins of these milk-borne compounds and evaluate their effect on infant growth and metabolism.

show abstract

“…Six articles met the criteria for meta-analysis (19,20,(23)(24)(25)(26). The excluded articles from the study (n=23) included the following: 5 articles presented the effect of breast milk ghrelin on growth in infants (6,18,21,22,27), 8 articles expressed no correlation between infants' serum ghrelin and growth (2, 17, 28-33), 3 articles were of descriptive nature (34-36), and 6 articles had an intervention group (37)(38)(39)(40)(41)(42).…”

Section: Resultsmentioning

confidence: 99%

Relationship Between Breast Milk Ghrelin and Infants’ Serum Ghrelin and Growth in Breastfeeding Infants: A Systematic Review and Meta-Analysis

et al. 2020

View full text Add to dashboard Cite

Background: There is positive correlation between infant serum ghrelin and the growth of infants in breastfed infants. Objectives: The present study aimed to evaluate of the relationship between breast milk ghrelin and serum ghrelin and growth in breast-milk-fed infants by systematic review and meta-analysis approaches. Methods: Electronic resources used in the current search were Scopus, Cochrane Library, Science Direct, PubMed, and EMBASE. The English language full-text articles and abstracts published from 1999 to July 2019 were collected. Only the articles that explored infants under two years of age and receiving breast milk exclusively were reviewed. Papers related to healthy mothers and infants were entered in this study. The results of 6 papers regarding the effect of serum ghrelin on the growth of infants, i.e., evaluated by meta-analysis using Stata software. The data addressing the effect of breast milk ghrelin on growth were reported by a systematic review manner; three articles were found in this area. We used Preferred Reporting Items for systematic reviews and meta-analyses (prisma) checklist for performing this study. Results: In this study, the association of infants' serum ghrelin with infants' growth was evaluated by meta-analysis. Newcastle-Ottawa Scale (NOS) value was ≥7scores for the 6 explored meta-analysis articles. The present meta-analysis research suggested a positive and significant correlation between infant serum ghrelin and the growth of infants (r=0.163). Conclusions: The random-effect model data demonstrated a positive and significant correlation between infant serum ghrelin and the growth of infants. However, in the study of the effect of breast milk ghrelin on infants' growth, the number of articles was limited and contradictory results were reported. Accordingly, no general conclusion was reached.

show abstract

Associations of breast milk adiponectin, leptin, insulin and ghrelin with maternal characteristics and early infant growth: a longitudinal study

Cited by 57 publications

References 44 publications

Influence of Diabetes during Pregnancy on Human Milk Composition

Influence of Diabetes during Pregnancy on Human Milk Composition

Growth Factor Concentrations in Human Milk Are Associated With Infant Weight and BMI From Birth to 5 Years

Relationship Between Breast Milk Ghrelin and Infants’ Serum Ghrelin and Growth in Breastfeeding Infants: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About