Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study

Sujana, Chaterina; Seißler, Jochen; Jordan, Jens; Rathmann, Wolfgang; Köenig, Wolfgang; Roden, Michael; Mansmann, Ulrich; Herder, Christian; Peters, Annette; Thorand, Barbara; Then, Cornelia

doi:10.1186/s12933-020-01117-1

Cited by 12 publications

(20 citation statements)

References 47 publications

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“…This finding was substantiated in a subsequent analysis. High plasma concentrations of mid-regional pro atrial natriuretic peptide (MR-proANP), another peptide from the natriuretic peptide system, were also associated with a lower risk of incident DM and insulin resistance [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease

Peter

Jaensch

Mons

et al. 2021

Cardiovasc Diabetol

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Background Diabetes mellitus (DM) and depression are bidirectionally interrelated. We recently identified long-term trajectories of depression symptom severity in individuals with coronary heart disease (CHD), which were associated with the risk for subsequent cardiovascular events (CVE). We now investigated the prognostic value of these trajectories of symptoms of depression with the risk of incident DM in patients with stable coronary heart disease. Methods The KAROLA cohort included CHD patients participating in an in-patient rehabilitation program (years 1999/2000) and followed for up to 15 years. We included 1048 patients (mean age 59.4 years, 15% female) with information on prevalent DM at baseline and follow-up data. Cox proportional hazards models were used to model the risk for incident DM during follow-up by depression trajectory class adjusted for age, sex, education, smoking status, body mass index, and physical activity. In addition, we modeled the excess risk for subsequent CVE due to incident DM during follow-up for each of the depression trajectories. Results DM was prevalent in 20.7% of patients at baseline. Over follow-up, 296 (28.2%) of patients had a subsequent CVE. During follow-up, 157 (15.0%) patients developed incident DM before experiencing a subsequent CVE. Patients following a high-stable depression symptom trajectory were at substantially higher risk of developing incident DM than patients following a low-stable depression symptom trajectory (hazard ratio (HR) = 2.50; 95% confidence interval (CI) (1.35, 4.65)). A moderate-stable and an increasing depression trajectory were associated with HRs of 1.48 (95%-CI (1.10, 1.98)) and 1.77 (95%-CI (1.00, 3.15)) for incident DM. In addition, patients in the high-stable depression trajectory class who developed incident DM during follow-up were at 6.5-fold risk (HR = 6.51; 95%-CI (2.77, 15.3)) of experiencing a subsequent cardiovascular event. Conclusions In patients with CHD, following a trajectory of high stable symptoms of depression was associated with an increased risk of incident DM. Furthermore, incident DM in these patients was associated with a substantially increased risk of subsequent CVE. Identifying depressive symptoms and pertinent treatment offers might be an important and promising approach to enhance outcomes in patients with CHD, which should be followed up in further research and practice.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease

Peter

Jaensch

Mons

et al. 2021

Cardiovasc Diabetol

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“…Glucose levels were measured in serum using a hexokinase method (GLUFlex, Dade Behring) at baseline and an enzymatic colorimetric method on a Dimension Vista 1500 instrument (Siemens) or the GLUC3 assay on a Cobas c702 instrument (Roche Diagnostics, Mannheim, Germany) at follow-up. 29 Hemoglobin A1c (HbA1c) was measured in hemolyzed whole blood using the cation-exchange high performance liquid chromatographic, photometric VARIANT II TURBO HbA1c Kit – 2.0 assay on a VARIANT II TURBO Hemoglobin Testing System (Bio-Rad Laboratories Inc, Hercules, USA). Insulin was measured by an electrochemiluminescence immunoassay on a Cobas e602 instrument (Roche) in KORA F4.…”

Section: Methodsmentioning

confidence: 99%

Association of renin and aldosterone with glucose metabolism in a Western European population: the KORA F4/FF4 study

Then

Ritzel

Herder

et al. 2022

BMJ Open Diab Res Care

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IntroductionPrimary aldosteronism is associated with impaired glucose tolerance. Whether plasma aldosterone and/or renin concentrations are associated with type 2 diabetes and continuous measures of glucose metabolism in the general population is still under debate.Research design and methodsThe analyses included 2931 participants of the KORA F4 study at baseline and 2010 participants of the KORA FF4 study after a median follow-up of 6.5 years. The associations of active plasma renin and aldosterone concentrations with type 2 diabetes and continuous measures of glucose metabolism were assessed using logistic and linear regression models. Results were adjusted for sex, age, body mass index (BMI), estimated glomerular filtration rate, potassium, use of ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics and calcium channel blockers.ResultsCross-sectionally, renin was associated with type 2 diabetes (OR per SD: 1.25, 95% CI 1.10 to 1.43, p<0.001), fasting glucose, 2-hour glucose, insulin, proinsulin, HOMA-B (homeostasis model assessment of beta cell function) and HOMA-IR (homeostasis model assessment of insulin resistance) (all p values <0.001). Aldosterone was not associated with type 2 diabetes (OR: 1.04, 95% CI 0.91 to 1.19; p=0.547) but with insulin, proinsulin and HOMA-IR (all p values <0.001). The aldosterone–renin ratio was inversely associated with type 2 diabetes and several measures of glucose metabolism. Longitudinally, neither renin (OR: 1.12, 95% CI 0.92 to 1.36) nor aldosterone (OR: 0.91, 95% CI 0.74 to 1.11) were associated with incident type 2 diabetes. Renin was inversely associated with changes of insulin concentrations.ConclusionsIn the KORA F4/FF4 study, renin and aldosterone were not associated with incident type 2 diabetes and largely unrelated to changes of measures of glucose metabolism. Cross-sectionally, aldosterone was associated with surrogate parameters of insulin resistance. However, these associations were not independent of renin.

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“…The following potential confounder variables were assessed at baseline and used for adjustment: sex, age, BMI, years of education (numerical), ever-smoking status (yes/no), leisure time physical activity (active/inactive [ 26 ]), parental diabetes (yes/no) and hypertension (yes/no, defined as >140/90 mmHg). In addition, baseline laboratory measures of total triacylglycerols (mmol/l), the ratio of total cholesterol to HDL-cholesterol (HDL-C), HOMA-IR and fasting serum glucose (mmol/l) were used as potential confounders [ 26 ]. HOMA-IR was calculated as previously described [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

“…In addition, baseline laboratory measures of total triacylglycerols (mmol/l), the ratio of total cholesterol to HDL-cholesterol (HDL-C), HOMA-IR and fasting serum glucose (mmol/l) were used as potential confounders [ 26 ]. HOMA-IR was calculated as previously described [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort

et al. 2022

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Aims/hypothesis The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology. Methods Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). All participants had repeated OGTTs and antibody measurements for herpes simplex virus (HSV) 1 and 2, varicella-zoster virus, Epstein–Barr virus, cytomegalovirus (CMV) and human herpesvirus 6 and 7. Regression models were used to evaluate the association between serostatus with (pre)diabetes incidence after a 7 year follow-up and HbA1c. Results HSV2 and CMV were associated with (pre)diabetes incidence after adjustment for sex, age, BMI, education, smoking, physical activity, parental diabetes, hypertension, lipid levels, insulin resistance and fasting glucose. Seropositivity of both viruses was also cross-sectionally associated with higher HbA1c at baseline, with the association of HSV2 being independent of confounders, including the prevalence of (pre)diabetes itself. While seropositivity for multiple herpesviruses was associated with a higher incidence of (pre)diabetes, this association was not independent of confounders. Conclusions/interpretation The associations of HSV2 and CMV serostatus with (pre)diabetes incidence indicate that these herpesviruses may contribute to the development of impaired glucose metabolism. Our results highlight the link between viral infection and (pre)diabetes, and the need for more research evaluating viral prevention strategies. Graphical abstract

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Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study

Cited by 12 publications

References 47 publications

Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease

Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease

Association of renin and aldosterone with glucose metabolism in a Western European population: the KORA F4/FF4 study

Health impact of seven herpesviruses on (pre)diabetes incidence and HbA1c: results from the KORA cohort

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