Associations of cardiovascular health assessed by life’s essential 8 with diabetic retinopathy and mortality in type 2 diabetes

Shen, Ruihuan; Guo, Xuan-Tong; Zou, Tong; Ma, Lihong

doi:10.1016/j.pcd.2023.08.001

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…Considering the well-established associations between diabetes and CVD, promoting CVH as a strategic approach for the prevention and management of diabetes could potentially alleviate the burden of diabetes. Previous studies have explored the relationship between LS7, LE8, and diabetes ( 14 – 18 ), yet no study has examined the associations between the newly launched LE8 and prediabetes. To address these research gaps, we conducted an in-depth analysis using data from the National Health and Nutrition Examination Surveys (NHANES) to comprehensively assess the connection between LE8 and various prediabetes subtypes, as well as diabetes, among US adults.…”

Section: Introductionmentioning

confidence: 99%

Association between the AHA life’s essential 8 and prediabetes/diabetes: a cross-sectional NHANES study

Xu,

Feng,

Abdullah

et al. 2024

Front. Endocrinol.

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Background and aimsThe American Heart Association (AHA) recently introduced the Life’s Essential 8 (LE8) to improve cardiovascular health (CVH). However, the association between LE8 and the risk of prediabetes or diabetes is not yet fully understood. Consequently, this study aims to assess the association between CVH, as evaluated by LE8, and the risk of prediabetes and diabetes.Methods and ResultsThis cross-sectional study encompassed 7,739 participants aged ≥20 years from the 2007-2018 National Health and Nutrition Examination Surveys (NHANES). The CVH of participants was evaluated using the LE8, combining four health behaviors and three health factors. Glucose metabolic status categories included normal glucose metabolism, prediabetes including isolated impaired fasting glucose, isolated impaired glucose tolerance, both IFG and IGT, and diabetes. The associations between CVH and prediabetes and diabetes were analyzed using logistic regression, linear regression, restricted cubic splines, and subgroup analyses. Among 7,739 participants, 1,949 had iIFG, 1,165 were diagnosed with iIGT, 799 were IFG+IGT, and 537 were diagnosed with diabetes. After multivariable adjustments, CVH scores were inversely associated with prediabetes and diabetes, with the most robust inverse association observed between IFG+IGT and CVH across all prediabetes subgroups. Of all CVH components not directly in the causal pathway, body mass index (BMI) had the most robust associations with prediabetes and diabetes. Subgroup analyses indicated that the negative correlation between CVH and prediabetes was stronger among those with university or higher education.ConclusionCVH, as defined by LE8, showed a significant negative association with prediabetes and diabetes.

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Section: Introductionmentioning

confidence: 99%

Association between the AHA life’s essential 8 and prediabetes/diabetes: a cross-sectional NHANES study

Xu,

Feng,

Abdullah

et al. 2024

Front. Endocrinol.

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Life's Essential 8 and its association with osteoarthritis and disability: a cross-sectional study based on the NHANES 2005–2018 database

Chen,

2024

Qual Life Res

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The correlation between Life’s essential 8 and cardiovascular disease and mortality in individuals with nonalcoholic fatty liver disease: a cross-sectional study

Sun,

Qiu,

Zhang

et al. 2024

Sci Rep

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It is currently unclear whether there is a connection between Life’s Essential 8 (LE8) and cardiovascular disease (CVD), as well as mortality in people with nonalcoholic fatty liver disease (NAFLD). Our goal was to explore these relationships by examining data collected in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. We identified eligible participants with NAFLD based on NHANES 2005–2018 data. CVD status was acquired through self-reported information, and using the National Death Index, mortality data were prospectively matched. The diagnosis of NAFLD relied on noninvasive biomarkers. The research involved 9094 individuals who were identified as having NAFLD, with a mean age of 52.05 years. Each incremental LE8 score exhibited a significant association, leading to a 3%, 3%, 4%, 3%, 3%, 4%, and 4% reduction in the odds of experiencing CVD, ischemic heart disease, congestive heart failure, coronary heart disease, heart attack, angina, and stroke in individuals with NAFLD. A strong correlation was found between maintaining a superior level of Cardiovascular Health (CVH), as shown by a LE8 score ranging from 80 to 100, and a reduced occurrence of CVD and its various forms in NAFLD (all p for trend < 0.0001). Likewise, LE8 demonstrated protective benefits on mortality in NAFLD, showing that following a high CVH (in contrast to low CVH) was linked to reductions of 64%, 71%, and 74% in all-cause, CVD, and cancer mortality, respectively. Restricted cubic spline analyses suggested noteworthy dose-response relationships between LE8 and CVD, specifically its types in NAFLD, and a nonlinear correlation with CVD mortality. Interaction analyses highlighted age and race as significant effect modifiers. CVH, as evaluated by LE8, demonstrated an independent association with decreased odds of CVD and mortality risk in individuals with NAFLD. Our findings substantiate that adhering to LE8 may alleviate the excessive burden of CVD and mortality in the context of NAFLD.

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Associations of cardiovascular health assessed by life’s essential 8 with diabetic retinopathy and mortality in type 2 diabetes

Cited by 4 publications

References 20 publications

Association between the AHA life’s essential 8 and prediabetes/diabetes: a cross-sectional NHANES study

Association between the AHA life’s essential 8 and prediabetes/diabetes: a cross-sectional NHANES study

Life's Essential 8 and its association with osteoarthritis and disability: a cross-sectional study based on the NHANES 2005–2018 database

The correlation between Life’s essential 8 and cardiovascular disease and mortality in individuals with nonalcoholic fatty liver disease: a cross-sectional study

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