Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis

Heikkilä, Katriina; Harris, Ross; Lowe, G. D. O.; Rumley, Ann; Yarnell, John; Gallacher, John; Ben-Shlomo, Yoav; Ebrahim, Shah; Lawlor, Debbie A.

doi:10.1007/s10552-008-9212-z

Cited by 267 publications

(281 citation statements)

References 72 publications

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“…The overall pooled HR per natural log unit change in CRP for all-cancer was 1.105 (95% CI: 1.033-1.178), with substantial heterogeneity amongst studies (P heterogeneity =0.000, I 2 =70.10%). When restricting the analysis to the multi-types of cancer (Il'Yasova et al, 2005;Siemes et al, 2006;Allin et al, 2009;Heikkila et al, 2009;Dos et al, 2010;Van et al, 2011), the pooled HR per natural log unit change in CRP increased to 1.155 (95% CI: 1.106-1.205, P heterogeneity =0.191, I 2 =31%). Figure 3 provides the detailed results of association between CRP levels and cancer risk in different sites.…”

Section: Resultsmentioning

confidence: 99%

“…For reporting different cancer type, both studies of Zhang et al (2007) and Zhang et al (2005) were inclusive, although their participants were from the same population. At last, 10 articles (Il'Yasova et al, 2005;Zhang et al, 2005;Siemes et al, 2006;Zhang et al, 2007;Allin et al, 2009;Heikkila et al, 2009;Pierce et al, 2009;Dos et al, 2010;Prizment et al, 2011;Van et al, 2011) including 11 cohort studies were eligible for inclusion criteria in this meta-analysis (one article including two separate cohorts (Heikkila et al, 2009)), involving a total of 194,796 participants and 11,459 cancer cases. Table 1 summarizes the baseline characteristics of 11 cohort studies included.…”

Section: Resultsmentioning

confidence: 99%

“…In studies of Van et al (2011) and Siemes et al (2006) where HR was reported based on various length of followup, the HR with the longer follow-up was used to compute. The results of a pooled analysis in all 11 included cohort studies (Il'Yasova et al, 2005;Zhang et al, 2005;Siemes et al, 2006;Zhang et al, 2007;Allin et al, 2009;Heikkila et al, 2009;Pierce et al, 2009;Dos et al, 2010;Prizment et al, 2011;Van et al, 2011) are shown in Figure 2. The overall pooled HR per natural log unit change in CRP for all-cancer was 1.105 (95% CI: 1.033-1.178), with substantial heterogeneity amongst studies (P heterogeneity =0.000, I 2 =70.10%).…”

Section: Resultsmentioning

confidence: 99%

“…Among them, most case-control studies have shown a higher cancer risk in people with elevated CRP levels (Gunter et al, 2006;Helzlsouer et al, 2006;Otani et al, 2006;Aleksandrova et al, 2010;Chaturvedi et al, 2010;Lee et al, 2011;Pine et al, 2011), while, the findings from prospective cohort studies have been inconsistent (Il'Yasova et al, 2005;Zhang et al, 2005;Siemes et al, 2006;Zhang et al, 2007;Allin et al, 2009;Heikkila et al, 2009;Pierce et al, 2009;Dos et al, 2010;Prizment et al, 2011;Van et al, 2011).…”

Section: Association Between C-reactive Protein and Risk Of Cancer: Amentioning

confidence: 99%

“…A previous meta-analysis exploring the association between CRP levels and cancer risk has been published in 2009 (Heikkila et al, 2009). From then on, more results from large-scale prospective cohort studies have been published, but the results were inconsistent.…”

Section: Association Between C-reactive Protein and Risk Of Cancer: Amentioning

confidence: 99%

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Association Between C-reactive Protein and Risk of Cancer: A Meta-analysis of Prospective Cohort Studies

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

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Section: Association Between C-reactive Protein and Risk Of Cancer: Amentioning

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Section: Association Between C-reactive Protein and Risk Of Cancer: Amentioning

confidence: 99%

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Risk of Malignancies in Patients With Rheumatoid Arthritis Treated With Biologic Therapy

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Evaluating individual biomarkers for predicting health risks in zoo‐housed chimpanzees (Pan troglodytes) and bonobos (Pan paniscus)

Edes

Brown

Edwards

2022

American J Primatol

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Although biomarkers are often used for predicting morbidity and mortality in humans, similar data are lacking in our closest relatives. This study analyzed 16 biomarkers in zoo‐housed chimpanzees and bonobos from serum samples collected during both routine and nonroutine veterinary immobilizations. Generalized linear and generalized linear mixed models were used to determine the efficacy of each biomarker to predict all‐cause morbidity, defined as the presence of at least one chronic condition, or cardiac disease as a subset of all‐cause morbidity. Cox proportional hazards models were used to examine associations between biomarkers and mortality risk from any cause. Analyses were conducted using two data sets for each species, one with all values retained (chimpanzees: n = 148; bonobos: n = 33) and the other from samples collected during routine immobilizations only (chimpanzees: n = 95; bonobos: n = 23). Consistent results across both data sets in chimpanzees included associations of higher cortisol with all‐cause morbidity risk, lower creatinine with cardiac disease risk, and higher creatinine with mortality risk, and in bonobos were increased cardiac disease risk with higher cortisol and lower dehydroepiandrosterone‐sulfate, fructosamine, and triglycerides. However, there were some inconsistencies between data sets, such as tumor necrosis factor‐α predicting mortality risk positively in chimpanzees when all values were retained, but negatively for routine values only. Despite the close evolutionary relationships between chimpanzees and bonobos, the only result observed in both species was a negative association between albumin and mortality risk in the all values retained data sets. Thus, data suggest some biomarkers may be useful predictors of future health outcomes, although a better understanding of both individual and species variation in biomarkers and their contribution to health risks is needed.

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Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis

Cited by 267 publications

References 72 publications

Association Between C-reactive Protein and Risk of Cancer: A Meta-analysis of Prospective Cohort Studies

Association Between C-reactive Protein and Risk of Cancer: A Meta-analysis of Prospective Cohort Studies

Risk of Malignancies in Patients With Rheumatoid Arthritis Treated With Biologic Therapy

Evaluating individual biomarkers for predicting health risks in zoo‐housed chimpanzees (Pan troglodytes) and bonobos (Pan paniscus)

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