Associations of Cord Blood Vitamin D and Preeclampsia With Offspring Blood Pressure in Childhood and Adolescence

Zhang, Mingyu; Michos, Erin D.; Wang, Guoying; Wang, Xiaobin; Mueller, Noel T.

doi:10.1001/jamanetworkopen.2020.19046

Cited by 19 publications

(14 citation statements)

References 66 publications

(109 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adults, some studies suggested that Se and Mn may have protective effects against hypertension and CVD, although there is also evidence of possible adverse effects, nonlinear relationships, or null effects of these elements on BP and CVD (Bulka et al 2019;Laclaustra et al 2009; Lee and Kim 2011; Mordukhovich et al 2012;Nawrot et al 2007;Wu et al 2017). In pregnant women, we reported in the Boston Birth Cohort (Liu et al 2019) and in Project Viva (Liu et al 2020) that higher maternal Mn levels were prospectively associated with lower risk of preeclampsia, a pregnancy complication characterized by high BP and a known risk factor for child high BP (Zhang et al 2020b). It is unclear how in utero exposure to Se and Mn is associated with BP in children.…”

Section: Introductionmentioning

confidence: 82%

“…In this Guideline, BP percentiles were calculated using new normative BP tables based on SBP and diastolic BP (DBP) readings arranged by age, sex, and height from ∼ 50,000 normal-weight children and adolescents (Flynn et al 2017). We used SBP as the primary outcome and DBP as the secondary outcome, because SBP is more strongly associated with hypertension and CVD in adulthood (Chen and Wang 2008;Sun et al 2007); this approach is consistent with our previous studies in the Boston Birth Cohort (Zhang et al 2018(Zhang et al , 2020b.…”

Section: Child Bpmentioning

confidence: 92%

See 1 more Smart Citation

In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort

Zhang

Liu

Wang

et al. 2021

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

BACKGROUND: In utero exposure to heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) may be associated with higher childhood blood pressure (BP), whereas trace elements selenium (Se) and manganese (Mn) may have protective antioxidant effects that modify metal-BP associations. OBJECTIVES: We examined the individual and joint effects of in utero exposure to Pb, Hg, Cd, Se, and Mn on childhood BP. METHODS: We used data from the Boston Birth Cohort (enrolled 2002Cohort (enrolled -2013. We measured heavy metals and trace elements in maternal red blood cells collected 24-72 h after delivery. We calculated child BP percentile per the 2017 American Academy of Pediatrics Clinical Practice Guideline. We used linear regression models to estimate the association of each metal, and Bayesian kernel machine regression (BKMR) to examine metal coexposures, with child BP between 3 to 15 years of age. RESULTS: Our analytic sample comprised 1,194 mother-infant pairs (61% non-Hispanic Black, 20% Hispanic). Hg and Pb were not associated with child systolic BP (SBP). Se and Mn were inversely associated with child SBP percentiles, which, on average, were 6.23 points lower with a doubling of Se (95% CI: −11:51, −0:96) and 2.62 points lower with a doubling of Mn (95% CI: −5:20, −0:04). BKMR models showed similar results. Although Cd was not associated with child SBP overall, the inverse association between Mn and child SBP was stronger at higher levels of Cd (p-interaction = 0:04). Consistent with this finding, in utero exposure to cigarette smoke modified the Mn-child SBP association. Among children whose mothers smoked during pregnancy, a doubling of Mn was associated with a 10.09-point reduction in SBP percentile (95% CI: −18:03, −2:15), compared with a 1.49-point reduction (95% CI: −4:21, 1.24) in children whose mothers did not smoke during pregnancy (p-interaction = 0:08). CONCLUSION: Se and Mn concentrations in maternal red blood cells collected 24-72 h after delivery were associated with lower child SBP at 3 to 15 years of age. There was an interaction between Mn and Cd on child SBP, whereby the protective association of Mn on child SBP was stronger among mothers who had higher Cd. The association of Mn and child SBP was also modified by maternal cigarette smoking-a source of Cd-during pregnancy. Optimizing in utero Se levels, as well as Mn levels in women who had high Cd or smoked during pregnancy, may protect offspring from developing high BP during childhood.

show abstract

Section: Introductionmentioning

confidence: 82%

Section: Child Bpmentioning

confidence: 92%

In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort

Zhang

Liu

Wang

et al. 2021

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, a randomized trial showed that vitamin D treatment did not affect the blood pressure of the patients compared to placebo [19]. A review [20] and a meta-analysis [21] revealed that vitamin D supplementation did not reduce blood pressure. These conclusions may be that the study population happens to be a low-magnesium population.…”

Section: Discussionmentioning

confidence: 99%

Dietary Magnesium Intake Modifies the Association Between Vitamin D and Systolic Blood Pressure: Results From NHANES 2007-2014.

Huang

Zheng

et al. 2021

Preprint

View full text Add to dashboard Cite

IntroductionAlthough the association between blood pressure and vitamin D has been well studied, the effects of dietary magnesium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary magnesium intake on the association between vitamin D and blood pressure.Research design and methodsThe present study analyzed data from the continuous NHANES 2007-2014. We included 8799 participants aged 20 years or older. Multivariable linear regression was performed to assess the association between vitamin D and systolic blood pressure (SBP), diastolic blood pressure (DBP). Dietary magnesium intake was stratified by low magnesium intake (<299mg/d), high magnesium intake (>=299mg/d). Effect modification by dietary magnesium intake was assessed through interaction tests between vitamin D and SBP in the multivariable linear regression.ResultsIn this cross-sectional study, we found vitamin D was negatively related to SBP, but not to DBP. The relationship between vitamin D and SBP was different in the low and high magnesium intake group (β: -0.18 95%Cl: -0.35-0 vs β: -0.3 95%Cl: -0.51- -0.1). Furthermore, magnesium intake significantly modified the negative relationship between vitamin D and SBP (P value for interaction: 0.026).ConclusionOur research showed that magnesium and vitamin D have an interactive effect in reducing SBP, which may have great importance for clinical medication.

show abstract

“…Hypertension in this population is the prominent risk factor for pregnancy-related hypertension, such as preeclampsia and eclampsia, which are the leading cause of maternal and fetal mortality. It is also associated with an increased risk of childhood adverse health outcomes in the long term, including asthma [ 5 ], elevated blood pressure [ 6 ], as well as some rare childhood cancers [ 7 ]. Furthermore, postmenopausal women’s unique physiological conditions can affect BP in several hormonal ways [ 8 ], which also provides a unique risk for hypertension-related cardiovascular risk.…”

Section: Introductionmentioning

confidence: 99%

Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014

Shen

Qian

et al. 2021

Environ Health

View full text Add to dashboard Cite

Background Vitamin D deficiency (VDD) may increase the risk of hypertension in women of childbearing age, who may be exposed to secondhand smoke (SHS) simultaneously. Till now, few studies have investigated the joint effects of VDD and SHS on hypertension in this population. We evaluated whether exposure to SHS modified the association between VDD and hypertension. Methods Data from National Health and Nutrition Examination Surveys (NHANES) 2007-2014 were analyzed. Our research subjects were 2826 nonsmoking and nonpregnant women of childbearing age (20-44 years old). Hypertension was defined based either on systolic blood pressure (SBP) ≥ 130 mmHg and/or diastolic blood pressure (DBP) ≥ 80 mmHg or on now taking prescribed medicine for hypertension. The directed acyclic graphs (DAG) and the back-door criterion were used to select a minimal sufficient adjustment set of variables (MSAs) that would identify the unconfounded effect of 25(OH)D and hypertension. The interactive effect of VDD and SHS on hypertension was evaluated by using logistic regression models, followed by strata-specific analyses. Results The prevalence of VDD in the hypertension group was significantly higher than that in the non-hypertension group (48.2% vs 41.0%, P = 0.008), as well as the exposure rate of SHS (39.1% vs 33.8%, P = 0.017). VDD was independently associated with nearly 50% increased risk of hypertension [adjusted odds ratio (aOR) = 1.43, 95% confidence interval (CI): 1.01, 2.04], while no significant association was observed between SHS and hypertension. However, SHS showed a significant synergistic effect on VDD with a higher aOR of 1.79 (95% CI: 1.14, 2.80) (Pinteraction = 0.011). This synergistic effect was more obvious when stratified by BMI (in overweight women, aOR, 95% CI =4.74, 1.65-13.60 for interaction vs 2.33, 1.01-5.38 for VDD only) and race (in Non-Hispanic Black women, aOR, 95% CI =5.11, 1.58-16.54 for interaction vs 2.69, 1.10-6.62 for VDD only). Conclusion There exist synergistic effects of SHS and VDD on the prevalence of hypertension in American women of childbearing age, with more significant effects in women who were overweight or Non-Hispanic Black. Further studies are warranted to verify this finding in other populations, and the molecular mechanisms underlying the joint effect of SHS and VDD need to be elucidated.

show abstract

Associations of Cord Blood Vitamin D and Preeclampsia With Offspring Blood Pressure in Childhood and Adolescence

Cited by 19 publications

References 66 publications

In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort

In Utero Exposure to Heavy Metals and Trace Elements and Childhood Blood Pressure in a U.S. Urban, Low-Income, Minority Birth Cohort

Dietary Magnesium Intake Modifies the Association Between Vitamin D and Systolic Blood Pressure: Results From NHANES 2007-2014.

Joint effect of 25-hydroxyvitamin D and secondhand smoke exposure on hypertension in non-smoking women of childbearing age: NHANES 2007-2014

Contact Info

Product

Resources

About