Associations of Current Wheeze and Body Mass Index with Perennial and Seasonal Allergic Rhinitis in Young Adults

Matsumoto, M.; Konno, Satoshi; Kimura, Hirokazu; Takei, Nozomu; Kimura, Hironobu; Shimizu, Kaoruko; Goudarzi, Houman; Suzuki, Masaru; Hashino, Satoshi; Nishimura, Masaharu

doi:10.1159/000488329

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…BMI was calculated as weight (kg) divided by height squared (m). Our previous studies analyzed BMI using continuous variables [12,13]. In this study, BMI was not normally distributed.…”

Section: Discussionmentioning

confidence: 99%

“…The height and weight of each participant were measured during the medical checkup after the entrance ceremony. The questionnaire used in this study was presented in a previous paper [13].…”

Section: Questionnairementioning

confidence: 99%

“…Therefore, understanding the differences in the pathophysiology and/or pathobiology of asthma and AR is necessary. Notably, some studies have reported a differential association between asthma and AR regarding the risk factors associated with comorbidities, including our previous report, where the contrasting association of smoking and obesity in these two conditions was described [12, 13]. Furthermore, several phenotypes have been proposed for the definition of AR; however, perennial AR (PAR) and seasonal AR (SAR) are the most well-known classifications [14].…”

Section: Introductionmentioning

confidence: 99%

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Nine-Year Trend in the Prevalence of Allergic Diseases and Their Associated Factors in Young Adults

Matsumoto,

Kimura,

Shimizu

et al. 2023

Int Arch Allergy Immunol

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Introduction: Notably, few studies have evaluated the recent changes in the prevalence of allergic diseases in young adults. Studies examining the risk of allergy in two populations with similar social backgrounds, other than the region in which they live, are rare. Methods: First-year students from Hokkaido University were enrolled in this study between 2011 and 2019. A questionnaire survey was conducted to determine the annual prevalence of current wheeze, seasonal allergic rhinitis (SAR), and perennial allergic rhinitis (PAR) in nonsmoking young adults. Trends in the presence of these disease conditions were evaluated based on their hometowns (Hokkaido and outside Hokkaido separately) due to the low prevalence of cedar pollen allergies in Hokkaido. The association between these disease conditions and body mass index (BMI) was also assessed. Results: The prevalence of current wheeze and PAR food allergies did not change in both regions. SAR showed a significantly increasing trend; however, the prevalence of SAR was higher among those whose place of origin was not Hokkaido. Current wheeze was positively associated with obesity (p < 0.05), whereas the high prevalence of SAR was not associated with body weight. In contrast, a lean body type was significantly associated with a higher prevalence of PAR (p < 0.05). Discussion/Conclusion: The prevalence of current wheeze was stable and that of PAR has decreased over the past 9 years. However, the prevalence of SAR in Hokkaido has been increasing in Japanese young adults. A differential association between current wheeze and BMI was observed when comparing PAR and SAR.

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“…BMI was calculated as weight (kg) divided by height squared (m). Our previous studies analyzed BMI using continuous variables [12,13]. In this study, BMI was not normally distributed.…”

Section: Discussionmentioning

confidence: 99%

Section: Questionnairementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nine-Year Trend in the Prevalence of Allergic Diseases and Their Associated Factors in Young Adults

Matsumoto,

Kimura,

Shimizu

et al. 2023

Int Arch Allergy Immunol

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“…In Japanese students, both seasonal and, in particular, perennial allergic rhinitis are significantly associated with a current wheeze [12]. A cross-sectional, observational study investigating real-world practice patterns for allergic rhinitis, asthma, chronic obstructive pulmonary disease, and rhinosinusitis in India, Korea, Malaysia, Singapore, Taiwan, and Thailand provided regional and country-specific information and suggested different practice patterns between specialists and general practitioners, and highlighted the substantial disease burden [13].…”

Section: Characterization Of Subgroups Of Allergic Rhinitismentioning

confidence: 99%

Recent Advances in Clinical Allergy and Immunology

Simon

2018

Int Arch Allergy Immunol

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Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients’ physical and psychological health, the huge burden they place on patients’ quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new technologies such as “omics” has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Immense progress has been made in developing and applying novel, targeted therapies, for example for asthma and urticaria. Intensive efforts are being made to find biomarkers that help to classify patients, to identify their potential responsiveness to specific therapies, and to monitor the disease severity. Based on recent insights in the pathogenesis of food allergy and drug hypersensitivity, novel strategies for diagnostics, allergen avoidance, and induction of tolerance have been developed. Here, we summarize important findings in the field of clinical allergy and immunology with a special focus on asthma, allergic rhinitis, atopic dermatitis, food allergy, urticaria, angioedema, and drug hypersensitivity.

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“…1 Traditionally, AR is a chronic upper-airway inflammatory disease with symptoms of nasal obstruction, sneezing, nasal pruritis, and clear rhinorrhea, 2 which is influenced by multiple factors such as genes and the environment. 3 Recently, dysfunctional epithelial integrity together with altered tight junctions (TJs) expression were found in patients with allergic inflammatory diseases. 4,5…”

Section: Introductionmentioning

confidence: 99%

Protease-Activated Receptor-2 Decreased Zonula Occlidens-1 and Claudin-1 Expression and Induced Epithelial Barrier Dysfunction in Allergic Rhinitis

Wang

Xue

Huang

et al. 2020

Am J Rhinol�Allergy

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Background Protease-activated receptor-2 (PAR-2)-modulated tight junctions (TJs) have been suggested to be involved in the pathogenesis of chronic inflammatory diseases. However, immunopathogenesis remains to be investigated among patients with allergic rhinitis (AR). Objective This study sought to investigate the role of PAR-2 in the modulation of epithelial barrier function and the expression of TJs in the nasal mucosa of AR patients. Methods The expression of TJs and PAR-2 of the nasal mucosa in AR patients and control subjects by immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and western blotting. In vitro, Primary human nasal epithelial cells (pHNECs) of AR patients were stimulated by Der p1 to analyze the correlation between PAR-2 and TJs expression. Der p1-induced pHNECs were treated with the PAR-2 agonist SLIGRL-NH2 and antagonist FSLLRY-NH2. Fluorescein isothiocyanate–dextran 4 kDa detection was employed as an indicator of epithelial permeability. Results Lower expression levels of TJs in the nasal epithelium of AR patients were observed in comparison with that in control subjects. The PAR-2 level was markedly increased following treatment with 1,000 ng/mL of Der p1 for 24 hours in a cellular model of AR. The expression of PAR-2 was increased in Der p1-induced pHNECs of AR patients and correlated inversely with zonula occlidens (ZO)-1 and claudin-1. Treatment with Der p1 further downregulated TJs expression and promoted an increased epithelial permeability in Der p1-induced pHNECs. Conclusions PAR-2 could downregulate the expression of ZO-1 and claudin-1, which is involved in epithelial barrier dysfunction in AR.

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Associations of Current Wheeze and Body Mass Index with Perennial and Seasonal Allergic Rhinitis in Young Adults

Cited by 7 publications

References 20 publications

Nine-Year Trend in the Prevalence of Allergic Diseases and Their Associated Factors in Young Adults

Nine-Year Trend in the Prevalence of Allergic Diseases and Their Associated Factors in Young Adults

Recent Advances in Clinical Allergy and Immunology

Protease-Activated Receptor-2 Decreased Zonula Occlidens-1 and Claudin-1 Expression and Induced Epithelial Barrier Dysfunction in Allergic Rhinitis

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