Associations of Dietary and Serum Copper with Inflammation, Oxidative Stress, and Metabolic Variables in Adults ,

Abstract

There are conflicting data on the associations between copper and glycemia, plasma lipids, and atherosclerotic diseases.Copper has both pro-oxidant and antioxidant effects. We performed a cross-sectional analysis to investigate the associations between dietary copper intake and metabolic variables and serum high-sensitivity C-reactive protein (hs-CRP) in asymptomatic subjects from a population-based cohort (n ¼ 1197) and between serum copper concentration and markers of oxidative stress, including plasma nitrotyrosine (NT) and total antioxidant status (TAS), hs-CRP, and metabolic variables in a subgroup of men from this cohort (n ¼ 231). In all subjects, diastolic blood pressure and circulating glucose, uric acid, and total and LDL-cholesterol concentrations significantly decreased, whereas the hs-CRP concentration increased, from the lowest to the highest tertile of copper intake. In the male subgroup, glucose and total and LDL-cholesterol and TAS decreased, whereas hs-CRP and NT concentrations increased from the lowest to the highest tertile of serum copper concentration. In multiple regression models, dietary copper intake was inversely associated with diastolic blood pressure (P ¼ 0.002), fasting glucose (P , 0.001), total cholesterol (P , 0.001), LDL-cholesterol (P , 0.001), and uric acid (P , 0.001) and was directly associated with the hs-CRP concentration (P , 0.001). Serum copper concentrations were inversely associated with glucose (P , 0.001), total cholesterol (P , 0.001), LDL-cholesterol (P , 0.001), and TAS (P , 0.001) and were directly associated with hs-CRP (P , 0.001) and NT concentrations (P , 0.001). Marginal copper deficiency is associated with an unfavorable metabolic pattern, but copper supplementation might not be recommended in view of its association with inflammation and markers of oxidative stress.

Copper-Zinc ratio and nutritional status in colorectal cancer patients during the perioperative period

“…Incremental changes of inflammatory biomarkers have been associated with augmented plasma Cu 26 . Approximately 90-95% of the total circulating Cu are bound to ceruloplasmin 7 , whose concentrations are elevated in response to inflammation, infection and various chronic diseases 6,7 .…”

Molecular bases of copper and iron deficiency-associated dyslipidemia: a microarray analysis of the rat intestinal transcriptome

“…[4]). Moreover, more recent studies reported statistically significant associations of dyslipidemia with marginal copper and iron deficiencies [5,6], whose molecular bases and regulatory events are still largely unknown. A microarray differential analysis of gene expression, in rat intestine of animals fed on copper-or iron-deficient diets, confirmed significant changes of transcript levels of genes involved in the pathways of fatty acids (FA) and cholesterol (CL) metabolism, thus leading to the identification of molecular targets affected by the dietary deficiencies.…”

Exploration of micro- and macronutrient consumption and leverage of interaction with adipokines among Jordanian adults

“…Data concerning the association between adipokine levels and copper consumption is scarce, however, copper and adiponectin are involved in several similar metabolic processes including oxidative defense system and glycemic control, in which the levels of adiponectin and copper were negatively, associated with the risk factors of abnormal health conditions such as diabetes, cardiovascular disease, and oxidative stress [69][70][71]. Additionally, copper has been suggested as a possible mediator of leptin levels regulation [72].…”