Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults

Abstract

BackgroundAntioxidant micronutrients have a therapeutic potential for clinical treatment of obesity. NO research, however, has examined the connection between the complex level of dietary antioxidants and obesity.Materials and methodsWe mainly aimed to investigate the relationship between a combination of antioxidants and obesity using the database of the national health and nutrition examination survey (NHANES). This cross-sectional study contains a survey of 41,021 people (≥18 years) in total ranging from 2005 to 2018. Multivariate logistic and weighted quantile sum (WQS) regression were performed to investigate the associations between these antioxidants, both individually and collectively, and the prevalence of obesity. The restricted cubic spline (RCS) regression was also utilized to analyze the linearity of these associations.ResultsAccording to multivariate logistic models, we found that the levels of most antioxidants in the highest quartile were independently related to a lower prevalence of obesity, while a reverse result was observed in selenium (p for trend <0.05). The WQS index revealed that a total of the 11 antioxidants is negatively related to the prevalence of obesity and abdominal obesity (all p<0.001), and iron/vitamin C have the greatest weight in the negative associations between antioxidant complex and obesity, as well as abdominal obesity. In addition, the RCS regression showed that retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and copper all had a non-linear association with obesity. Threshold effect analysis demonstrated that the inflection points of retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and cooper were 235.57, 374.81, 58.89, 891.44, 30.70, 43,410.00, 11,240.00, and 990.00 μg/day, respectively.ConclusionOur study found that a high level of a complex of 11 dietary antioxidants is related to a lower prevalence of obesity and abdominal obesity, among this inverse associations iron and vitamin C have the greatest weight.

The Circulating Selenium Concentration Is Positively Related to the Lipid Accumulation Product: A Population-Based Cross-Sectional Study

“…Furthermore, a previous NHANES study also reported that the Se dietary intake was unrelated to the BMI and WC [37]. Nevertheless, another study revealed a positive correlation between Se dietary intake and obesity in adults [38].…”

Effectiveness of Bay Leaves (Syzygium polyanthum) to Reduce Body Mass Index Among Pre-Menopausal Obese Adults in South Jakarta Regency

“…Vitamin C has been found to scavenge free radicals and suppress lipid peroxidation, which can lead to decreased vitamin C levels in obese individuals due to increased body fat and oxidative stress (Y. Yang et al, 2023). Vitamin C may inhibit metabolic changes induced by certain stressors like high-fat diets, with studies showing that high doses of vitamin C can induce weight loss safely in obese individuals (Yuan et al, 2021).…”

The Importance of Micronutrient Adequacy in Obesity and the Potential of Microbiota Interventions to Support It

“…Several studies have suggested that the rate of increase in obesity is greater in regions of the world with greater micronutrient deficiencies [17], while others reported significant inverse associations between the dietary intake of micronutrients and Body Mass Index (BMI) and/or obesity [18][19][20][21][22]. These studies were cross-sectional and hence failed to demonstrate the cause-and-effect relationship between micronutrient deficiencies and excess weight unequivocally.…”