2022
DOI: 10.3389/fnut.2022.854774
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Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies

Abstract: ObjectiveTo comprehensively summarize the evidence on the associations of dietary copper, selenium, and manganese intake with depression based on a meta-analysis of observational studies.MethodsThe electronic database of PubMed, Web of Science, and Embase were searched up to January 7, 2022, for observational studies on the associations of dietary copper, selenium and manganese intake with depression (no restriction was set for the initiate time). The pooled relative risk (RR) of depression for the highest vs.… Show more

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Cited by 16 publications
(18 citation statements)
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“…The pathophysiology of depression is involved in oxidative stress, and high levels of selenium intake are significantly associated with a lower risk of depression. 11,36 Selenium can also affect the growth and proliferation of follicles through antioxidant effects. 37 Selenium is indispensable for the proper functioning of various selenoproteins involved in antioxidant defenses within the brain and nervous system.…”
Section: Discussionmentioning
confidence: 99%
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“…The pathophysiology of depression is involved in oxidative stress, and high levels of selenium intake are significantly associated with a lower risk of depression. 11,36 Selenium can also affect the growth and proliferation of follicles through antioxidant effects. 37 Selenium is indispensable for the proper functioning of various selenoproteins involved in antioxidant defenses within the brain and nervous system.…”
Section: Discussionmentioning
confidence: 99%
“…After adjusting for these confounding factors, the current study found that dietary selenium intake regulated the association between infertility and depressive symptoms. The pathophysiology of depression is involved in oxidative stress, and high levels of selenium intake are significantly associated with a lower risk of depression 11,36 . Selenium can also affect the growth and proliferation of follicles through antioxidant effects 37 .…”
Section: Discussionmentioning
confidence: 99%
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“…Additionally, a case-control study of 849 Korean adolescent girls aged 12-18 years also indicated that there was a high risk of depression in participants who ate more instant and processed foods and that dietary copper intake was negatively related to depression, suggesting that a reasonable dietary pattern played an important role in preventing and managing depression (Kim et al, 2015). Furthermore, an inverse association between dietary copper intake and depression was observed to be more relevant in women than in men (Thi Thu Nguyen et al, 2019;Ding and Zhang, 2022). Therefore, adequate intake of copper and reasonable dietary pattern was very important in preventing depression.…”
Section: Copper Supplementation For the Prevention And Treatment Of D...mentioning
confidence: 98%