Associations of dietary fats intake and adipokines levels in obese women

Nasir, Yasaman; Farzollahpour, Forough; Mirzababaei, Atieh; Maghbooli, Zhila

doi:10.1016/j.clnesp.2021.03.018

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…Lipid β-oxidation generated a large number of electrons in the mitochondrial respiratory chain, producing excessive reactive oxygen species (ROS) ( 35 ). Linoleic acid is a polyunsaturated fatty acid that cannot be synthesized in the body and must be obtained from dietary sources ( 36 ). It has been reported that linoleic alcohol is related to atherosclerosis and inflammatory diseases, being a main component of the cell plasma membrane and a precursor to fatty acids such as prostaglandins and leukotrienes ( 37 ).…”

Section: Resultsmentioning

confidence: 99%

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

et al. 2023

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ObjectiveIn this study, the structure of Pleurotus eryngii polysaccharides (PEPs) was characterized, and the mechanism of PEP on obesity and hyperlipidemia induced by high-fat diet was evaluated by metabonomic analysis.MethodsThe structure of PEPs were characterized by monosaccharide composition, Fourier transform infrared spectroscopy and thermogravimetry. In animal experiments, H&E staining was used to observe the morphological difference of epididymal adipose tissue of mice in each group. Ultrahigh performance liquid chromatography (UHPLC)-(QE) HFX -mass spectrometry (MS) was used to analyze the difference of metabolites in serum of mice in each group and the related metabolic pathways.ResultsThe PEPs contained nine monosaccharides: 1.05% fucose, 0.30% arabinose, 17.94% galactose, 53.49% glucose, 1.24% xylose, 23.32% mannose, 1.30% ribose, 0.21%galacturonic acid, and 1.17% glucuronic acid. The PEPs began to degrade at 251°C (T0), while the maximum thermal degradation rate temperature (Tm) appeared at 300°C. The results histopathological observation demonstrated that the PEPs had signifificant hypolipidemic activities. After PEPs intervention, the metabolic profile of mice changed significantly. A total of 29 different metabolites were selected as adjunctive therapy to PEPs, for treatment of obesity and hyperlipidemia-related complications caused by a high-fat diet. These metabolites include amino acids, unsaturated fatty acids, choline, glycerol phospholipids, and other endogenous compounds, which can prevent and treat obesity and hyperlipidemia caused by a high-fat diet by regulating amino acid metabolism, fatty acid metabolism, and changes in metabolic pathways such as that involved in the citric cycle (TCA cycle).ConclusionsThe presented results indicate that PEPs treatment can alleviate the obesity and hyperlipidemia caused by a high-fat diet and, thus, may be used as a functional food adjuvant, providing a theoretical basis and technical guidance for the prevention and treatment of high-fat diet-induced obesity and hyperlipidemia.

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Section: Resultsmentioning

confidence: 99%

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

et al. 2023

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“…Previous work has demonstrated that a MUFA-rich diet can prevent central fat distribution and down-regulate postprandial adiponectin expression in insulin-resistant subjects [43]. Nasir et al have shown that MUFA consumption is significantly and positively associated with plasma omentin concentrations among women with obesity [44]. Therefore, it could be hypothesized that increased MUFA intake is a driver of the positive effects of AOF on vaspin and omentin circulating levels.…”

Section: Discussionmentioning

confidence: 99%

A Mediterranean Eating Pattern Combining Energy and Time-Restricted Eating Improves Vaspin and Omentin Concentrations Compared to Intermittent Fasting in Overweight Individuals

Karras,

Koufakis,

Popovic

et al. 2023

Nutrients

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Athonian Orthodox fasting (AOF) is characterized by energy- and time-restricted eating (TRE) and is based on the Mediterranean diet. We aimed to investigate the impact of AOF compared to another TRE model on vaspin, omentin, nesfatin, and visfatin levels. We included 25 individuals (mean age 50.3 ± 8.6 years, 24% men) who practiced AOF and abstained from animal products, with the exception of seafood and fish. This group adopted a 12 h eating interval (08.00 to 20.00). In total, 12 participants (mean age 47.7 ± 8.7 years, 33.3% men) who practiced 16:8 TRE (eating from 09:00 to 17:00) and were allowed to consume meat served as the controls. Anthropometric and dietary data and adipokine levels were prospectively collected at three time points: at baseline, after the end of the diets (7 weeks), and 5 weeks after the participants returned to their typical eating habits (12 weeks from baseline). Vaspin levels decreased [795.8 (422.1–1299.4) (baseline) vs. 402.7 (203.8–818.9) (7 weeks) pg/mL, p = 0.002] and omentin levels increased [568.5 (437.7–1196.5) (baseline) vs. 659.0 (555.7–1810.8) (12 weeks) pg/mL, p = 0.001] in the AOF group, while none of the analyzed adipokines changed significantly in the TRE group. The variations observed in vaspin and omentin concentrations in the AOF group were independent of age, sex, changes in anthropometry and fat intake. In conclusion, AOF can significantly reduce vaspin and increase omentin, whose levels are known to increase and decrease, respectively, in obesity and type 2 diabetes. The implications of these findings for cardiometabolic health warrant further investigation.

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“…The various compounds found in whole flaxseed lead to beneficial effects on circulating levels of leptin and adiponectin. Fatty acids through interaction with transcription factors such as PPARγ, CCAAT/enhancer-binding protein (C/EBP), and sterol regulatory element-binding transcription factor 1 (SREBPF1) can alter the expression of leptin and adiponectin (45). Moreover, the anti-inflammatory properties of omega-3 fatty acids contribute to the regulation of adipokine production (46).…”

Section: Summary Of Findingsmentioning

confidence: 99%

Can flaxseed supplementation affect circulating adipokines in adults? An updated systematic review and meta-analysis of randomized controlled trials

Abbasi,

Karimi,

Hossein Moridpour

et al. 2023

Front. Nutr.

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IntroductionThe findings of randomized controlled trials (RCTs) regarding the effect of flaxseed on adipokine concentrations are conflicting. Therefore, the present meta-analysis was conducted to provide definite and conclusive results.MethodsSystematically, Scopus, Embase, PubMed, Web of Science databases, and Google Scholar were searched for relevant literature published up to December 2022. Based on random-effect models, standard mean differences (SMDs) were calculated for net changes in adipokine concentrations.ResultsOverall, 13 RCTs (15 arms) were eligible to be included. The results indicated that leptin was significantly reduced after the intervention with flaxseed supplement (SMD = −0.69, 95% CI: −1.37, −0.01; p = 0.048; I2 = 92.0%, p < 0.001). In addition, flaxseed supplements had no considerable effect on plasma adiponectin (SMD = 0.52, 95% CI: −0.20, 1.25, p = 0.159; I2 = 92.0%, p < 0.001).DiscussionFlaxseed significantly improves leptin but does not affect adiponectin concentrations. Additional future well-designed trials are required to further assess the potential benefits of flaxseed on adipokines in humans.

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Associations of dietary fats intake and adipokines levels in obese women

Cited by 5 publications

References 48 publications

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

Hypolipidemic mechanism of Pleurotus eryngii polysaccharides in high-fat diet-induced obese mice based on metabolomics

A Mediterranean Eating Pattern Combining Energy and Time-Restricted Eating Improves Vaspin and Omentin Concentrations Compared to Intermittent Fasting in Overweight Individuals

Can flaxseed supplementation affect circulating adipokines in adults? An updated systematic review and meta-analysis of randomized controlled trials

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