Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies

Ding, Jun; Zhang, Yi

doi:10.3389/fnut.2022.857823

Cited by 20 publications

(19 citation statements)

References 59 publications

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“…Li et al used NHANES data from 2009 to 2014 to show that copper is inversely related to depressive symptoms, which is consistent with the results of our study ( 39 ). In contrast to our study, a meta-analysis of 25 observational studies showed an inverse association between vitamin E and depressive symptoms ( 40 ). Second, our study showed that, after adjusting for a variety of nutrients, caffeine consumption is positively associated with depressive symptoms.…”

Section: Discussioncontrasting

confidence: 99%

“…Factor 3, mainly vitamins and dietary fiber, was negatively correlated with depressive symptoms and CRP, with the same results in the entire group, the >50-year-old subgroup, and the male subgroup. A meta-analysis showed that vitamin C intake was inversely associated with depressive symptoms ( 40 ), and that tocopherol treatment prevented TNF-α-induced depressive symptoms in mice ( 42 ). In addition, studies showed that oxidative stress in patients with depressive symptoms increases ( 43 , 44 ), and the intake of vitamin C, vitamin E, and folic acid is related to a reduction in oxidative stress ( 45 – 47 ).…”

Section: Discussionmentioning

confidence: 99%

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Inflammation mediated the effect of dietary fiber on depressive symptoms

Zhang

Cui²,

Zhang³

et al. 2023

Front. Psychiatry

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Background and aimsPrevious studies showed that inflammation affects depressive symptoms. Dietary fiber may be associated with inflammation and depressive symptoms. We aimed to investigate the relationship between inflammation and depressive symptoms at different levels of dietary fiber intake and to explore whether dietary fiber affects depression through inflammation.MethodsA total of 8,430 National Health and Nutrition Examination Survey (NHANES) samples were collected between 2015 and 2018. Factor analysis was used to determine dietary patterns. Linear regression and logistic regression analysis were used to explore the relationship between nutrients, inflammation, and depressive symptoms, and the mediation analysis was conducted using the bootstrap method.ResultsFactor 3 (dietary fiber and vitamins) was inversely associated with depressive symptoms and inflammation. The upper quartile scores of the dietary inflammatory index (DII) and C-reactive protein (CRP) were associated with depressive symptoms compared with controls (DII: OR = 1.851, 95% CI: 1.267–2.705; CRP: OR = 1.737, 95% CI: 1.136–2.656). The DII score and CRP were associated with depressive symptoms in the group with low dietary fiber intake (DII: OR = 2.736, 95% CI: 1.628–4.598; CRP: OR = 2.092, 95% CI: 1.196–3.658) but not in the high dietary fiber intake group. Mediating analysis showed that CRP partially mediated the effect of dietary fiber intake on depressive symptoms (βindirect = −0.0025, 95% CI: −0.0038 to −0.0013), and the mediated proportion was 10.5%.ConclusionIn this study, we found that DII scores and CRP were not associated with depressive symptoms in participants with high dietary fiber intake, and inflammation partially mediates the effect of dietary fiber on depressive symptoms.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inflammation mediated the effect of dietary fiber on depressive symptoms

Zhang

Cui²,

Zhang³

et al. 2023

Front. Psychiatry

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“…In addition, con icting results were also found in two meta-analyses [20,21]. A meta-analysis involving 25 observational studies demonstrated a negative relationship between vitamin C and depression [20]. Conversely, another meta-analysis showed that vitamin C supplementation was ineffective for reducing depressive symptoms [21].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C is vital for human health as it plays a critical role in human metabolism and is utilized in the treatment of oxidative stress-related diseases [15]. To date, several studies have been conducted to investigate the relationship between vitamin C and depression [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Association between serum vitamin C and depression in adults: A cross-sectional study of NHANES from 2017 to 2018

Zhao,

Long,

Wang

2024

Preprint

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Background The objective of this cross-sectional study was to explore the association between serum vitamin C and depression in adults. Methods Data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) cycle were utilized. Multivariable logistic regressions were applied to assess the association between serum vitamin C and depression. Restricted cubic spline (RCS) regression was conducted to explore the dose-response relationship between serum vitamin C and depression. In addition, we performed stratified and sensitivity analyses to evaluate the stability of the results. Results A total of 4517 participants were included in this study. Among of them, 410 (9.08%) participants suffered depression. In fully adjusted models, serum vitamin C, as a continuous variable, was negatively associated with depression (OR = 0.69, 95%CI: 0.54–0.88, P = 0.003). Similar results were observed when serum vitamin C was analyzed as a categorical variable. The ORs (95% CI) for Q2, Q3, and Q4, with Q1 as the reference, were 1.00 (0.76–1.33), 0.73 (0.54–0.99), and 0.59 (0.42–0.81), respectively. The RCS analysis found a linear negative relationship between serum vitamin C and depression (P for non-linearity = 0.579). Additionally, the inverse associations between serum vitamin C and depression remained robust in stratified and sensitivity analyses. Conclusion Our findings suggested that there was a linear negative relationship between serum vitamin C and the risk of depression, indicating that maintaining sufficient serum vitamin C are recommended due to its potential benefits for protecting against depression.

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“…For example, the intake of dietary sugar, fat, and protein in life also contains some additives such as sweeteners, preservatives, and other ingredients, and their relationships with depression are not clear, which should be addressed in follow-up studies. Furthermore, the nutritional elements associated with depression not only include those summarized in the article but also involve vitamins [ 176 , 177 , 178 ], folic acid [ 179 ], N-acetylcysteine [ 180 ], S-adenozylmetionine [ 181 ], dietary fiber [ 182 ], etc., which also need to be considered. This article suggests that to better prevent and treat depression, people should gradually focus on the role of nutrients in depression and their daily diet, such as low-sugar and low-fat diets.…”

Section: Discussionmentioning

confidence: 99%

Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression

Zhengyang

Quan

et al. 2023

IJMS

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Depression is a common mental disorder that seriously affects the quality of life and leads to an increasing global suicide rate. Macro, micro, and trace elements are the main components that maintain normal physiological functions of the brain. Depression is manifested in abnormal brain functions, which are considered to be tightly related to the imbalance of elements. Elements associated with depression include glucose, fatty acids, amino acids, and mineral elements such as lithium, zinc, magnesium, copper, iron, and selenium. To explore the relationship between these elements and depression, the main literature in the last decade was mainly searched and summarized on PubMed, Google Scholar, Scopus, Web of Science, and other electronic databases with the keywords “depression, sugar, fat, protein, lithium, zinc, magnesium, copper, iron, and selenium”. These elements aggravate or alleviate depression by regulating a series of physiological processes, including the transmission of neural signals, inflammation, oxidative stress, neurogenesis, and synaptic plasticity, which thus affect the expression or activity of physiological components such as neurotransmitters, neurotrophic factors, receptors, cytokines, and ion-binding proteins in the body. For example, excessive fat intake can lead to depression, with possible mechanisms including inflammation, increased oxidative stress, reduced synaptic plasticity, and decreased expression of 5-Hydroxytryptamine (5-HT), Brain Derived Neurotrophic Factor (BDNF), Postsynaptic density protein 95(PSD-95), etc. Supplementing mineral elements, such as selenium, zinc, magnesium, or lithium as a psychotropic medication is mostly used as an auxiliary method to improve depression with other antidepressants. In general, appropriate nutritional elements are essential to treat depression and prevent the risk of depression.

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Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies

Cited by 20 publications

References 59 publications

Inflammation mediated the effect of dietary fiber on depressive symptoms

Inflammation mediated the effect of dietary fiber on depressive symptoms

Association between serum vitamin C and depression in adults: A cross-sectional study of NHANES from 2017 to 2018

Appropriate Macronutrients or Mineral Elements Are Beneficial to Improve Depression and Reduce the Risk of Depression

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