Associations of Early and Late Gestational Weight Gain with Infant Birth Size

Wander, Pandora L.; Sitlani, Colleen M.; Badon, Sylvia E.; Siscovick, David S.; Williams, Michelle A.; Enquobahrie, Daniel A.

doi:10.1007/s10995-015-1765-3

Cited by 10 publications

(13 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in contrast with our findings showing that GWG was strongly related to birth length and LAZ and with those results reported by Gondwe et al (2018) showing that average weekly weight gain was positively associated with birthweight and LAZ. However, in another U.S. study of 3,601 women (Wander et al, 2015), a 1-kg increase in total GWG was associated with a +0.04-cm difference in HC, a value that it is virtually identical to the one observed in our cohort. Gondwe et al also found that average b Any level of food insecurity by the Household Food Insecurity Access Scale (Coates et al, 2007).…”

Section: Discussionsupporting

confidence: 83%

“…Only a few studies have examined the relationship between GWG and other anthropometric birth outcomes such as LAZ (Dahly et al, ; Diesel et al, ), HCZ (Wander et al, ), and BMIZ (Diesel et al, ). In Ireland, birth length did not differ significantly between infants of mothers with excessive GWG and those of mothers with inadequate or healthy GWG (Dahly et al, ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gestational weight gain and newborn anthropometric outcomes in rural Bangladesh

Kac

Matias

Mridha

et al. 2019

Maternal & Child Nutrition

View full text Add to dashboard Cite

Low gestational weight gain (GWG) is a known predictor of fetal growth restriction in higher income countries, but there is little information on this association in lower income countries. Our objective is to describe the association between GWG and birth outcomes among pregnant women in rural Bangladesh. Pregnant women were identified in a community‐based programme and enrolled into the study at an average of 13 weeks' gestation (n = 4,011). Maternal weight and height were measured at enrolment, maternal weight was measured at 36 weeks' gestation, and newborns were measured after birth. Rate of GWG (g/weeks) was calculated, and women were categorized as having adequate or inadequate GWG (Institute of Medicine recommendations). Newborn anthropometric outcomes included weight‐for‐age z score (WAZ), length‐for‐age z score (LAZ), head‐circumference‐for‐age z score (HCZ), body mass index (BMI)‐for‐age z score (BMIZ), low birthweight (LBW < 2,500 g), WAZ < −2, LAZ < −2, HCZ < −2, BMIZ < −2, and small for gestational age (SGA: <10th percentile). Multivariate models were adjusted for confounders. Only 26% of the 2,562 women in these analyses had adequate GWG. Compared with newborns of women with inadequate GWG, infants of women with adequate GWG had a lower risk of adverse anthropometric outcomes (relative risk [95% confidence interval]: LBW = 0.68 [0.59, 0.80], LAZ < −2 = 0.64 [0.51, 0.80], HCZ < −2 = 0.75 [0.60, 0.93], BMIZ < −2 = 0.70 [0.59, 0.83], and SGA = 0.80 [0.73, 0.86]), but there was no significant difference in mean (SE) duration of gestation, 39.7 (0.08) versus 39.7 (0.05) weeks. In this population, GWG rate is a strong predictor of newborn anthropometric outcomes, but not duration of gestation.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Gestational weight gain and newborn anthropometric outcomes in rural Bangladesh

Kac

Matias

Mridha

et al. 2019

Maternal & Child Nutrition

View full text Add to dashboard Cite

show abstract

“…With regards to later infant and childhood weight or BMI outcomes, we did not find any associations with total or trimester-specific GWG, neither within nor between twin pairs. Our results confirm previous research which found that both total and trimester-specific GWG were significantly associated with offspring BW in unrelated individuals (comparable to our between-pair effects; Abrams & Selvin, 1995;Margerison-Zilko et al, 2012;Starling et al, 2015;Wander et al, 2015), although some studies found that the association with offspring BW was limited to early and/or mid-pregnancy (Abrams & Selvin, 1995;Brown et al, 2002;Margerison-Zilko et al, 2012;Sekiya et al, 2007;Starling et al, 2015;Wander et al, 2015). Once controlling for shared genes and environment in the within-pair model, we found an effect of total GWG on offspring BW, which is in line with earlier studies (using a similar study design with siblingpairs; Berglind et al, 2014;Lawlor et al, 2011;Ludwig & Currie, 2010).…”

Section: Discussionsupporting

confidence: 92%

Total and Trimester-Specific Gestational Weight Gain and Offspring Birth and Early Childhood Weight: A Prospective Cohort Study on Monozygotic Twin Mothers and Their Offspring

et al. 2016

View full text Add to dashboard Cite

Gestational weight gain (GWG) has in numerous studies been associated with offspring birth weight (BW) and childhood weight. However, these associations might be explained by genetic confounding as offspring inherit their mother's genetic potential to gain weight. Furthermore, little is known about whether particular periods of pregnancy could influence offspring body weight differently. We therefore aimed to explore total and trimester-specific effects of GWG in monozygotic (MZ) twin mother-pairs on their offspring's BW, weight at 1 year and body mass index (BMI) at 5 and 10 years. MZ twin mothers born 1962-1975 were identified in national Swedish registers, and data on exposure and outcome variables was collected from medical records. We analyzed associations within and between twin pairs. We had complete data on the mothers' GWG and offspring BW for 82 pairs. The results indicated that total, and possibly also second and third trimester GWG were associated with offspring BW within the twin pairs in the fully adjusted model (␤ = 0.08 z-score units, 95% CI: 0.001, 0.17; ␤ = 1.32 z-score units, 95% CI: -0.29, 2.95; and ␤ = 1.02 z-score units, 95% CI: -0.50, 2.54, respectively). Our findings, although statistically weak, suggested no associations between GWG and offspring weight or BMI during infancy or childhood. Our study suggests that total, and possibly also second and third trimester, GWG are associated with offspring BW when taking shared genetic and environmental factors within twin pairs into account. Larger family-based studies with long follow-up are needed to confirm our findings.Keywords: gestational weight gain, gestational trimester, birth weight, childhood body weight, genetics, monozygotic twins GWG has been extensively studied over the past two decades and an excessive GWG has been associated with adverse pregnancy-related and childhood outcomes. These include gestational diabetes and increased risk of high BW and overweight and obesity in the offspring (Diesel et al., 2015;Guo et al., 2015;Hedderson, et al., 2010;Ludwig & Currie, 2010;Oken et al., 2007;Wrotniak et al., 2008). There is also evidence that GWG might have different effects on offspring BW and childhood weight/BMI, depending on the timing of the weight gain. The majority of the studies that have investigated trimester-specific effects of GWG on BW or adiposity at birth found effects for all trimesters (Abrams

show abstract

“…This association persisted at 6 and 12 months following adjustment for gestational age, labour and birth size (Table ). Two groups that represented either high (>1 SD above the mean) or low (>1 SD below the mean) birth size categories were generated . A low birth size was associated with slightly lower nTreg proportion at birth and 6 months of age (Figure B, Table ).…”

Section: Resultsmentioning

confidence: 99%

Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy

Collier

Ponsonby

O’Hely

et al. 2019

Allergy

View full text Add to dashboard Cite

Background:In previous studies, deficits in regulatory T-cell (Treg) number and function at birth have been linked with subsequent allergic disease. However, longitudinal studies that account for relevant perinatal factors are required. The aim of this study was to investigate the relationship between perinatal factors, naïve Treg (nTreg) over the first postnatal year and development of food allergy. Methods:In a birth cohort (n = 1074), the proportion of nTreg in the CD4 + T-cell compartment was measured by flow cytometry at birth (n = 463), 6 (n = 600) and 12 (n = 675) months. IgE-mediated food allergy was determined by food challenge at 1 year. Associations between perinatal factors (gestation, labour, sex, birth size), nTreg at each time point and food allergy at 1 year were examined by linear regression. Results:A higher proportion of nTreg at birth, larger birth size and male sex was each associated with higher nTreg in infancy. Exposure to labour, as compared to delivery by prelabour Caesarean section, was associated with a transient decrease nTreg.Infants that developed food allergy had decreased nTreg at birth, and the labour-associated decrease in nTreg at birth was more evident among infants with subsequent food allergy. Mode of birth was not associated with risk of food allergy, and there was no evidence that nTreg at either 6 or 12 months were related to food allergy. Conclusion:The proportion of nTreg at birth is a major determinant of the proportion present throughout infancy, highlighting the importance of prenatal immune development. Exposure to the inflammatory stimulus of labour appears to reveal differences in immune function among infants at risk of food allergy. K E Y W O R D S food allergy, naïve regulatory T cells, perinatal factors | 1761 COLLIER Et aL. S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. How to cite this article: Collier F, Ponsonby A-L, O'Hely M, et al. Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy. Allergy.

show abstract

Associations of Early and Late Gestational Weight Gain with Infant Birth Size

Cited by 10 publications

References 25 publications

Gestational weight gain and newborn anthropometric outcomes in rural Bangladesh

Gestational weight gain and newborn anthropometric outcomes in rural Bangladesh

Total and Trimester-Specific Gestational Weight Gain and Offspring Birth and Early Childhood Weight: A Prospective Cohort Study on Monozygotic Twin Mothers and Their Offspring

Naïve regulatory T cells in infancy: Associations with perinatal factors and development of food allergy

Contact Info

Product

Resources

About