Associations of essential element serum concentrations with autism spectrum disorder

Wu, Jing; Wang, Dongfang; Yan, Lailai; Jia, Mengmeng; Zhang, Jishui; Han, Song‐Ping; Han, Ji-Sheng; Wang, Jingyu; Chen, Xi

doi:10.1007/s11356-022-21978-1

Cited by 7 publications

(6 citation statements)

References 58 publications

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“…Prior to our study described above, it has been suggested that dyshomeostasis in selenium may be associated with ASD incidence ( Raymond et al, 2014 ). Since our study, others have also reported an association between ASD and low plasma Se levels ( Wu et al, 2022 ; Zhang et al, 2022 ). However, as a whole, the literature on this subject has been equivocal.…”

Section: Selenium and Selenoproteins In Autism Spectrum Disordersupporting

confidence: 70%

The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

Behl

Mehta

Pandey

2023

Front. Mol. Neurosci.

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Selenium and selenoproteins play a role in many biological functions, particularly in brain development and function. This review outlines the role of each class of selenoprotein in human brain function. Most selenoproteins play a large antioxidant role within the brain. Autism spectrum disorder (ASD) has been shown to correlate with increased oxidative stress, and the presumption of selenoproteins as key players in ASD etiology are discussed. Further, current literature surrounding selenium in ASD and selenium supplementation studies are reviewed. Finally, perspectives are given for future directions of selenoprotein research in ASD.

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Section: Selenium and Selenoproteins In Autism Spectrum Disordersupporting

confidence: 70%

The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

Behl

Mehta

Pandey

2023

Front. Mol. Neurosci.

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“…Lollipops containing vitamin C or D and zinc are, for example, currently commercially available for the potential facilitation of immunocompetance. Zinc concentrations are often low in autistic children [ 53 , 54 , 55 ] and are associated with symptom severity [ 56 ]. There has also been research indicating that oxytocin may become more stable after binding to zinc and that low levels of zinc may actually impair the ability of oxytocin to bind to its receptor [ 57 , 58 ].…”

Section: Discussion and Future Potential Developments And Applicationsmentioning

confidence: 99%

Oromucosal Administration of Oxytocin: The Development of ‘Oxipops’

Xu,

Lan,

Kou

et al. 2024

Pharmaceutics

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The role of the hypothalamic neuropeptide oxytocin in influencing the brain and behavior has been the subject of widespread research over the last few decades due, most notably, to its reported involvement in promoting social cognition and motivation, reducing anxiety, and relieving pain. It is also increasingly being considered as an important therapeutic intervention in a variety of disorders with social dysfunction as a symptom. While, in recent years, studies in humans have administered oxytocin primarily via an intranasal route, since it may partly enter the brain directly this way via the olfactory and trigeminal nerves, there is increasing evidence that many of its functional effects can be peripherally mediated via increasing its concentration in the blood. This has opened up an oromucosal administration route as an alternative, which is beneficial since the oral consumption of peptides is problematic due to their rapid breakdown in the acidic environment of the gastrointestinal system. In this review we will discuss both the methodologies we have developed for administering oxytocin via lingual application and medicated lollipops, ‘oxipops’, in terms of increasing blood concentrations and the bioavailability of the peptide, and also their validation in terms of functional effects on the brain and behavior. While areas under the curve are significantly greater in terms of plasma oxytocin concentrations following intranasally relative to oromucosally administered oxytocin, with the estimated absolute bioavailability of the latter being around 4.4% compared with 11.1% for intranasal administration, the time to peak concentrations (around 30 min) and functional effects on the brain and behavior are broadly similar. We will also discuss potential therapeutic advantages of the oromucosal administration of oxytocin in different clinical contexts and its wider application for other peptides which are increasingly being developed for therapeutic use.

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“…Our results for selenium were mixed, doubling of late pregnancy selenium concentration was associated with lower risk of non-typical development, however there were opposite effect estimates between cohorts. Selenium supplementation in an animal model attenuated autism phenotype (Wu et al 2022a), and studies measuring selenium cross-sectionally in children in Saudi Arabia (El-Ansary et al 2017) and China (Wu et al 2022b) found lower selenium levels in those with ASD. On the other hand, two-sample Mendelian randomization analysis using genetic instruments of blood and blood-toenail selenium suggest selenium levels are associated with increased risk of ASD (Guo et al 2023), and in the Boston Birth Cohort maternal red blood cell selenium levels measured at near delivery were associated with increased odds of ASD in children (Lee et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Exposure to heavy metalsin uteroand autism spectrum disorder at age 3: A meta-analysis of two longitudinal cohorts of siblings of children with autism

Dou,

Schmidt,

Volk

et al. 2023

Preprint

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BackgroundAutism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal environmental factors, though the environmental agents are incompletely characterized.MethodsIn Early Autism Risk Longitudinal Investigation (EARLI) and Markers of Autism Risk in Babies Learning Early Signs (MARBLES), two pregnancy cohorts of siblings of children with ASD, maternal urinary metals concentrations at two time points during pregnancy were measured using inductively coupled plasma mass spectrometry. At age three, clinicians assessed ASD with DSM-5 criteria. Using multivariable log binomial regression, we examined each metal for association with ASD status, adjusting for gestational age at urine sampling, child sex, maternal age, and maternal education, and meta-analyzed across the two cohorts.ResultsIn EARLI (n=170) 17.6% of children were diagnosed with ASD, and an additional 43.5% were classified as having other non-neurotypical development (Non-TD). In MARBLES (n=156), 22.7% were diagnosed with ASD, while an additional 11.5% had Non-TD. In earlier pregnancy metals measures, having cadmium concentration over the level of detection was associated with 1.78 (1.19, 2.67) times higher risk of ASD, and 1.43 (1.06, 1.92) times higher risk of Non-TD. A doubling of early pregnancy cesium concentration was marginally associated with 1.81 (0.95, 3.42) times higher risk of ASD, and 1.58 (0.95, 2.63) times higher risk of Non-TD.ConclusionExposurein uteroto elevated levels of cadmium and cesium, as measured in maternal urine collected during pregnancy, was associated with increased risk of developing ASD.

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Associations of essential element serum concentrations with autism spectrum disorder

Cited by 7 publications

References 58 publications

The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

The role of selenoproteins in neurodevelopment and neurological function: Implications in autism spectrum disorder

Oromucosal Administration of Oxytocin: The Development of ‘Oxipops’

Exposure to heavy metalsin uteroand autism spectrum disorder at age 3: A meta-analysis of two longitudinal cohorts of siblings of children with autism

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