Associations of FcɛRIβ E237G polymorphism with wheezing in Taiwanese schoolchildren

Lee, Yungling Leo; Gilliland, Frank D.; Wang, J. Y.; Lee, Y. C.; Guo, Yang

doi:10.1111/j.1365-2222.2007.02916.x

Cited by 6 publications

(1 citation statement)

References 47 publications

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“…The interactions between ozone-provoked inflammatory responses and subsequent development of asthma phenotypes are complex, and likely depend on highly individualized host responses. Children that have diminished ability to be sensitized, for example those with diminished IgE responses— e.g ., Fc εR1 functional polymorphisms—have less frequent wheezing with ozone exposure [27]. Most the information linking ozone exposure with early childhood sensitization in the context of childhood asthma is based on very limited computational estimations of exposure [28].…”

Section: Introductionmentioning

confidence: 99%

Biochemical effects of ozone on asthma during postnatal development

Auten

Foster

2011

Biochimica et Biophysica Acta (BBA) - General Subjects

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Section: Introductionmentioning

confidence: 99%

Biochemical effects of ozone on asthma during postnatal development

Auten

Foster

2011

Biochimica et Biophysica Acta (BBA) - General Subjects

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Antioxidant genes and susceptibility to air pollution for respiratory and cardiovascular health

Fuertes

Plaat

Minelli

2020

Free Radical Biology and Medicine

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Interactive Effects of Antioxidant Genes and Air Pollution on Respiratory Function and Airway Disease: A HuGE Review

Minelli¹,

Wei²,

Sagoo³

et al. 2011

American Journal of Epidemiology

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Susceptibility to the respiratory effects of air pollution varies between individuals. Although some evidence suggests higher susceptibility for subjects carrying variants of antioxidant genes, findings from gene-pollution interaction studies conflict in terms of the presence and direction of interactions. The authors conducted a systematic review on antioxidant gene-pollution interactions which included 15 studies, with 12 supporting the presence of interactions. For the glutathione S-transferase M1 gene (GSTM1) (n=10 studies), only 1 study found interaction with the null genotype alone, although 5 observed interactions when GSTM1 was evaluated jointly with other genes (mainly NAD(P)H dehydrogenase [quinone] 1 (NQO1)). All studies on the glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism (n=11) provided some evidence of interaction, but findings conflicted in terms of risk allele. Results were negative for glutathione S-transferase T1 (GSTT1) (n=3) and positive for heme oxygenase 1 (HMOX-1) (n=2). Meta-analysis could not be performed because there were insufficient data available for any specific gene-pollutant-outcome combination. Overall the evidence supports the presence of gene-pollution interactions, although which pollutant interacts with which gene is unclear. However, issues regarding multiple testing, selective reporting, and publication bias raise the possibility of false-positive findings. Larger studies with greater accuracy of pollution assessment and improved quality of conduct and reporting are required.

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Associations of FcɛRIβ E237G polymorphism with wheezing in Taiwanese schoolchildren

Abstract: The FcepsilonRIbeta E237G allele may have a protective role in wheezing illness among Taiwanese schoolchildren, depending on airway oxidative stress levels.

Cited by 6 publications

References 47 publications

Biochemical effects of ozone on asthma during postnatal development

Biochemical effects of ozone on asthma during postnatal development

Antioxidant genes and susceptibility to air pollution for respiratory and cardiovascular health

Interactive Effects of Antioxidant Genes and Air Pollution on Respiratory Function and Airway Disease: A HuGE Review

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