2020
DOI: 10.1001/jamanetworkopen.2019.19462
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Associations of Fish Oil Supplement Use With Testicular Function in Young Men

Abstract: IMPORTANCE Many young men have poor semen quality, and the causes are often unknown. Supplement intake of ω-3 polyunsaturated fatty acid has been found to improve semen quality among men with infertility, but the association with semen quality among healthy men is unknown. OBJECTIVE To determine if intake of ω-3 fatty acid supplements is associated with testicular function as measured by semen quality and reproductive hormone levels among healthy men. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional stud… Show more

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Cited by 29 publications
(35 citation statements)
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“…In this study, poor sperm morphology was associated with the lack of milk consumption and also the intake of skimmed or semi‐skimmed milk, suggesting that whole milk is protective of semen quality. Previously, a high intake of omega‐3 polyunsaturated fats has been reported to be positively associated with sperm morphology 41 and fish oil supplements with semen volume and total sperm count 42 . Such results are consistent with the presence, in whole milk, of numerous fat‐soluble vitamins and other components that might affect semen quality, for example, by providing protection against oxidative stress 43 .…”
Section: Discussionsupporting
confidence: 62%
“…In this study, poor sperm morphology was associated with the lack of milk consumption and also the intake of skimmed or semi‐skimmed milk, suggesting that whole milk is protective of semen quality. Previously, a high intake of omega‐3 polyunsaturated fats has been reported to be positively associated with sperm morphology 41 and fish oil supplements with semen volume and total sperm count 42 . Such results are consistent with the presence, in whole milk, of numerous fat‐soluble vitamins and other components that might affect semen quality, for example, by providing protection against oxidative stress 43 .…”
Section: Discussionsupporting
confidence: 62%
“…Supplementation with omega-3 fatty acids is reported to be associated with better testicular function (Jensen et al, 2020). However, there are currently no guidelines for optimal nutritional recommendations or antioxidant use in males across a range of BMI, although appropriate nutritional advice based on the Mediterranean diet for example, is warranted in the management of all male infertility cases.…”
Section: Lifestyle Modificationsmentioning
confidence: 99%
“…Higher OFA intake results in increased normal sperm morphology [ 246 , 247 ], volume [ 248 ], concentration [ 246 , 249 ], motility [ 246 , 249 ] and total sperm count [ 246 , 248 ]. OFA supplementation has proven to result in higher TAC and lower DNA fragmentation than non-supplemented groups [ 250 ].…”
Section: Antioxidantsmentioning
confidence: 99%
“…In a 2020 cross-sectional study, sperm quality results of an OFA supplementation were measured in two groups according to the length of the intervention, less than 60 days and more than 60 days. The group with a lengthier supplementation showed significantly improved sperm quality parameters than the <60 days group [ 248 ]. The latter suggests a more prolonged OFA supplementation could potentially benefit sperm quality parameters more than a short-term intervention.…”
Section: Antioxidantsmentioning
confidence: 99%