Associations of Functional Status and Depressive Symptoms with Health-related Quality of Life in Cancer Patients

Pinquart, Martin; Koch, A.; Eberhardt, Barbara; Brix, Christina; Wedding, Ulrich; Röhrig, Bernd

doi:10.1007/s11136-006-0016-x

Cited by 24 publications

(18 citation statements)

References 17 publications

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“…Depression tended to have somewhat stronger effects than pain, and depression-pain comorbidity yielded the greatest impairment. The relationship between symptom burden and quality of life in cancer patients has been noted,6 as has the particularly strong effects of depression 63,64. The frequent co-occurrence of pain-depression (45% in our sample) and their additive adverse effects make them an especially pernicious symptom dyad 21.…”

Section: Discussionmentioning

confidence: 59%

The Association of Depression and Pain with Health-Related Quality of Life, Disability, and Health Care Use in Cancer Patients

Kroenke

Theobald²,

et al. 2010

Journal of Pain and Symptom Management

212

151

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Context Pain and depression are two of the most prevalent and treatable cancer-related symptoms, each present in at least 20-30% of oncology patients. Objectives To determine the associations of pain and depression with health-related quality of life (HRQL), disability, and health care use in cancer patients. Methods The Indiana Cancer Pain and Depression (INCPAD) study is a randomized clinical trial comparing telecare management vs. usual care for patients with cancer-related pain and/or clinically significant depression. In this paper, baseline data on patients enrolled from 16 urban or rural community-based oncology practices are analyzed to test the associations of pain and depression with HRQL, disability, and health care use. Results Of the 405 participants, 32% had depression only, 24% pain only, and 44% both depression and pain. The average Hopkins Symptom Checklist 20-item (HSCL-20) depression score in the 309 depressed participants was 1.64 (on 0-4 scale), and the average Brief Pain Inventory (BPI) severity score in the 274 participants with pain was 5.2 (on 0-10 scale), representing at least moderate levels of symptom severity. Symptom-specific disability was high, with participants reporting an average of 16.8 days out of the past 28 (i.e., 60% of their days in the past four weeks) in which they were either confined to bed (5.6 days) or had to reduce their usual activities by 50% (11.2 days) due to pain or depression. Moreover, 176 (43%) reported being unable to work due to health-related reasons. Depression and pain had both individual and additive adverse associations with quality of life. Most patients were currently not receiving care from a mental health or pain specialist. Conclusion Depression and pain are prevalent and disabling across a wide range of types and phases of cancer, commonly co-occur, and have additive adverse effects. Enhanced detection and management of this disabling symptom dyad is warranted.

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Section: Discussionmentioning

confidence: 59%

The Association of Depression and Pain with Health-Related Quality of Life, Disability, and Health Care Use in Cancer Patients

Kroenke

Theobald²,

et al. 2010

Journal of Pain and Symptom Management

212

151

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“…In cancer patients, both functional status and depression affected HRQoL [17]. However, an interaction effect was also found: In patients with low functional status, as compared to those with high functional status, depression had no additional impact on HRQoL.…”

Section: Discussionmentioning

confidence: 88%

Impact of depression on quality of life assessment in heart failure

Faller¹,

Steinbüchel²,

Störk³

et al. 2010

International Journal of Cardiology

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“…Pinquart et al reported that a lower level of depressive symptoms was associated with better quality of life in cancer patients [21]. Frick et al reported that anxiety and depression were significantly correlated with impaired quality of life [4].…”

Section: Discussionmentioning

confidence: 99%

Quality of life, anxiety, and depression in Turkish colorectal cancer patients

Alacacıoğlu

Binicier

Güngör

et al. 2009

Support Care Cancer

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One hundred ten patients with colorectal cancer undergoing chemotherapy who presented to Dokuz Eylul University Faculty of Medicine, Department of Oncology between January 2004 and April 2007 were included in this study. The series of forms including the questions regarding the demographic characteristics of the patient, Turkish version of the Beck Depression Inventory (BDI), the Turkish version of the STAI, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC-QLQ-C30; version 3) were completed during face-to-face interviews by trained interviewers to determine the psychological status and quality of life of the patients. The mean Beck depression scores were 11.2 +/- 9.0 (range 0-44) and the mean STAI scores were 41.9 +/- 8.8 (range 22-71). Of the patients (Beck depression scores >or=17 points), 23.6% were determined as depressive. The EORTC-QLQ-C30 function scales and global quality of life scores of the depressive patients (BDI >or= 17) were significantly lower than that of the nondepressive patients (BDI < 17). EORTC-QLQ-C30 symptom scale scores (excluding of the diarrhea) of the depressive patients were significantly higher than that of the nondepressive patients. The patients with low STAI scores (STAI < 45) had significantly higher EORTC-QLQ-C30 function scales and global quality of life scores than the patients with high STAI scores (STAI >or= 45). EORTC-QLQ-C30 symptom scale scores of the patients with high STAI scores were significantly higher than that of the patients with low STAI scores. In the present study, we detected that anxiety and depression were strongly associated with poor quality of life in Turkish colorectal cancer patients.

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Associations of Functional Status and Depressive Symptoms with Health-related Quality of Life in Cancer Patients

Cited by 24 publications

References 17 publications

The Association of Depression and Pain with Health-Related Quality of Life, Disability, and Health Care Use in Cancer Patients

The Association of Depression and Pain with Health-Related Quality of Life, Disability, and Health Care Use in Cancer Patients

Impact of depression on quality of life assessment in heart failure

Quality of life, anxiety, and depression in Turkish colorectal cancer patients

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