Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study

Yang, Weili; Braun, Joseph M.; Vuong, Ann M.; Percy, Zana; Xu, Yingying; Xie, Changchun; Deka, Ranjan; Calafat, Antònia M.; Ospina, María; Burris, Heather H.; Yolton, Kimberly; Cecil, Kim M.; Lanphear, Bruce P.; Chen, Aimin

doi:10.1016/j.envpol.2022.120516

Environmental Pollution

2023

DOI: 10.1016/j.envpol.2022.120516

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Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study

Weili Yang

Joseph M. Braun

Ann M. Vuong

et al.

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Cited by 5 publications

(1 citation statement)

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“…The following supporting information can be downloaded at: , Table S1: Identity and purity of Chemicals; Table S2: Extracted exposure data and most sensitive endpoint (MSE) ranking (concentration in uM); Table S3: All endpoints of cytotoxicity data with their different assays and data source; Table S4: All BMCs from endpoint; Table S5: most sensitive BMC by function and institute; Table S6: MSE; Table S7: MSSE2; Table S8: ICE Active calls; Table S9: ICE QC-Omit; Table S10: Biomonitoring Data. References [ 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ] are cited in the Supplementary Materials.…”

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confidence: 99%

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Kreutz,

Oyetade,

Chang

et al. 2024

Toxics

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Organophosphorus flame retardants (OPFRs) are abundant and persistent in the environment but have limited toxicity information. Their similarity in structure to organophosphate pesticides presents great concern for developmental neurotoxicity (DNT). However, current in vivo testing is not suitable to provide DNT information on the amount of OPFRs that lack data. Over the past decade, an in vitro battery was developed to enhance DNT assessment, consisting of assays that evaluate cellular processes in neurodevelopment and function. In this study, behavioral data of small model organisms were also included. To assess if these assays provide sufficient mechanistic coverage to prioritize chemicals for further testing and/or identify hazards, an integrated approach to testing and assessment (IATA) was developed with additional information from the Integrated Chemical Environment (ICE) and the literature. Human biomonitoring and exposure data were identified and physiologically-based toxicokinetic models were applied to relate in vitro toxicity data to human exposure based on maximum plasma concentration. Eight OPFRs were evaluated, including aromatic OPFRs (triphenyl phosphate (TPHP), isopropylated phenyl phosphate (IPP), 2-ethylhexyl diphenyl phosphate (EHDP), tricresyl phosphate (TMPP), isodecyl diphenyl phosphate (IDDP), tert-butylphenyl diphenyl phosphate (BPDP)) and halogenated FRs ((Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), tris(2-chloroethyl) phosphate (TCEP)). Two representative brominated flame retardants (BFRs) (2,2′4,4′-tetrabromodiphenyl ether (BDE-47) and 3,3′,5,5′-tetrabromobisphenol A (TBBPA)) with known DNT potential were selected for toxicity benchmarking. Data from the DNT battery indicate that the aromatic OPFRs have activity at similar concentrations as the BFRs and should therefore be evaluated further. However, these assays provide limited information on the mechanism of the compounds. By integrating information from ICE and the literature, endocrine disruption was identified as a potential mechanism. This IATA case study indicates that human exposure to some OPFRs could lead to a plasma concentration similar to those exerting in vitro activities, indicating potential concern for human health.

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confidence: 99%

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Kreutz,

Oyetade,

Chang

et al. 2024

Toxics

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Pollution characteristics and risk assessment of organophosphate esters (OPEs) in typical industrial parks in Southwest China

Yin,

Liu,

Xiong

et al. 2024

Environ Sci Pollut Res

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Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years

Wang

Zhang

Wang³

et al. 2023

Eco-Environment & Health

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Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study

Cited by 5 publications

References 86 publications

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants

Pollution characteristics and risk assessment of organophosphate esters (OPEs) in typical industrial parks in Southwest China

Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years

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