Associations of Habitual Dietary Intake With Fecal Short-Chain Fatty Acids and Bowel Functions in Irritable Bowel Syndrome

Abstract

Background & Goals: Diet may contribute to symptoms of irritable bowel syndrome (IBS) and luminal production of putative IBS biomarkers including short-chain fatty acids (SCFAs). Study aims were to to assess relationships of habitual fiber or starch intake with fecal SCFAs in patients with IBS and healthy volunteers (HVs). Study: In 18 HVs and 30 patients with IBS (13 constipation-predominant [IBS-C] and 17 diarrhea-predominant [IBS-D]), habitual diet using a food frequency questionnaire; bowel functions using a validated bowel diary; and fecal SCFAs by HPLC-mass spectrometry were assessed. Associations of fiber and starch with SCFAs were analyzed using Spearman (r s ) and Pearson (R) correlations. Relationships between other dietary endpoints, SCFAs, and bowel functions were explored. Results: Habitual fiber or starch intakes were not significantly correlated with SCFAs or bowel functions in all participants or HVs nor with SCFAs in IBS. Starch was negatively correlated (R=−0.53; P=0.04) with complete evacuation in IBS-D. Fiber (r s =0.65; P=0.02) and starch (r s =0.56; P=0.05) were correlated with ease of passage in IBS-C. Stool form, frequency, and ease of passage were positively correlated with total SCFAs (all P<0.05), acetate (all P<0.01), propionate (all P<0.05), and butyrate (form P=0.01; ease of passage P=0.05) among all participants, but not in IBS. Complete evacuation was negatively correlated with propionate (R=−0.34; P=0.04) in all participants. Total (P=0.04) and individual SCFAs (all P<0.05) were positively correlated with stool form in HVs. Conclusions: Habitual fiber and starch intake does not influence fecal SCFAs but may influence bowel functions in IBS. Fecal SCFAs correlate with bowel functions among all participants including HVs.

A systematic review and meta‐analysis of diet and nutrient intake in adults with irritable bowel syndrome

“…Fiber intake was analyzed from 24 studies 11,15,16,43,44,[48][49][50]54,56,63,66,68,69,86,87,[89][90][91]94,98,[102][103][104][105] (N = 3388 participants with IBS, N = 7179 controls) to demonstrate lower intake in participants with IBS compared to controls with high heterogeneity (MD: −1.8 g; 95% CI: −3.0, −0.6; I 2 = 85%, Figure 3).…”

“…Fat intake was analyzed from 19 studies 11,15,16,44,[48][49][50]54,56,62,63,69,87,89,90,[93][94][95][96][97][98][99][101][102][103][104] (N = 2369 participants with IBS, N = 5021 controls). There was no significant difference between participants with IBS and controls with moderate heterogeneity (MD: −2 g; 95% CI: −5.3, 1.2; I 2 = 59%).…”

Posbióticos: ¿qué son y qué evidencia existe en trastornos intestino-cerebro?

“…Se han publicado también varios estudios que relacionan a los TIIC con los productos que entran en la categoría de metabolitos microbianos como el butirato, pero esto sería tema de otra revisión debido a que, de acuerdo con la definición actual, no se consideran posbióticos 31,32 .…”

Associations of Fecal Short Chain Fatty Acids With Colonic Transit, Fecal Bile Acid, and Food Intake in Irritable Bowel Syndrome

“…Despite these challenges, studies evaluating relationships between fecal SCFAs and quantitative features in IBS, rather than clinical phenotypes, have yielded more consistent findings. Prior research has shown an inverse correlation between fecal SCFA levels and colonic transit time (CTT) ( 10 – 12 ) and associations of SCFAs with stool form and frequency ( 13 , 14 ), suggesting that SCFAs are linked to physiologic features in IBS. However, it is unclear whether excreted SCFAs are stable physiological traits in IBS or whether measurements are determined by modifiable factors such as diet.…”

“…However, it is unclear whether excreted SCFAs are stable physiological traits in IBS or whether measurements are determined by modifiable factors such as diet. Although some studies have failed to show clear changes in SCFAs after dietary interventions in IBS ( 15 , 16 ) and no clear association between SCFAs and habitual diet based on dietary recall ( 13 ), data on the effects of actual food intake during stool collection are lacking.…”