Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population

Wang, Chuang‐Wei; Lin, Wei‐Chen; Chen, Wei-Ti; Chen, Chun‐Bing; Lu, Chun‐Wei; Hou, Hsin‐Han; Hui, Rosaline Chung‐Yee; Wu, Jennifer D.; Chang, Chi-Jen; Chang, Ya‐Ching; Chung, Wen‐Hung

doi:10.3389/fphar.2022.954596

Cited by 7 publications

(2 citation statements)

References 66 publications

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“… Bellon et al (2022) also revealed the association between HLA-A*32:01 and vancomycin-induced DRESS in Spanish population. Recently, we reported the association between HLA-A*32:01, HLA-B*07:05, HLA-B:40:06, HLA-B*67:01 and vancomycin-induced DRESS in Taiwanese population ( Wang et al, 2022c ). However, Lee et al (2022) reported that there is no association between HLA-A*32:01 and vancomycin-induced SCARs in Korean population according to clinical data from Seoul National University Hospital.…”

Section: Hla Susceptibility To Drug-induced Scarmentioning

confidence: 99%

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

Wung¹,

Wang²,

Lai³

et al. 2023

Front. Pharmacol.

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Drug-induced delayed hypersensitivity reactions (DHRs) is still a clinical and healthcare burden in every country. Increasing reports of DHRs have caught our attention to explore the genetic relationship, especially life-threatening severe cutaneous adverse drug reactions (SCARs), including acute generalized exanthematous pustulosis (AGEP), drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). In recent years, many studies have investigated the immune mechanism and genetic markers of DHRs. Besides, several studies have stated the associations between antibiotics-as well as anti-osteoporotic drugs (AOD)-induced SCARs and specific human leukocyte antigens (HLA) alleles. Strong associations between drugs and HLA alleles such as co-trimoxazole-induced DRESS and HLA-B*13:01 (Odds ratio (OR) = 45), dapsone-DRESS and HLA-B*13:01 (OR = 122.1), vancomycin-DRESS and HLA-A*32:01 (OR = 403), clindamycin-DHRs and HLA-B*15:27 (OR = 55.6), and strontium ranelate (SR)-SJS/TEN and HLA-A*33:03 (OR = 25.97) are listed. We summarized the immune mechanism of SCARs, update the latest knowledge of pharmacogenomics of antibiotics- and AOD-induced SCARs, and indicate the potential clinical use of these genetic markers for SCARs prevention in this mini review article.

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Section: Hla Susceptibility To Drug-induced Scarmentioning

confidence: 99%

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

Wung¹,

Wang²,

Lai³

et al. 2023

Front. Pharmacol.

Self Cite

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“…HLA-A*32:01 has also been associated with vancomycin DRESS in Asian populations; however, it is potentially not the only association with this allele less commonly represented. In addition, since vancomycin DRESS has a median latency of 3 weeks countries that step-down earlier to oral therapy experience less vancomycin DRESS in their populations 89. F I G U R E 1 Phenotypes, endotypes, and biomarkers in drug hypersensitivity.…”

mentioning

confidence: 99%

Changing patterns in the epidemiology of drug allergy

Doña,

Torres,

Celik

et al. 2023

Allergy

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Drug allergy (DA) remains a complex and unaddressed problem worldwide that often deprives patients of optimal medication choices and places them at risk for life‐threatening reactions. Underdiagnosis and overdiagnosis are common and due to the lack of standardized definitions and biomarkers. The true burden of DA is unknown, and recent efforts in data gathering through electronic medical records are starting to provide emerging patterns around the world. Ten percent of the general population engaged in health care claim to have a DA, and the most common label is penicillin allergy. Up to 20% of emergency room visits for anaphylaxis are due to DA and 15%–20% of hospitalized patients report DA. It is estimated that DA will increase based on the availability and use of new and targeted antibiotics, vaccines, chemotherapies, biologicals, and small molecules, which are aimed at improving patient's options and quality of life. Global and regional variations in the prevalence of diseases such as human immunodeficiency virus and mycobacterial diseases, and the drugs used to treat these infections have an impact on DA. The aim of this review is to provide an update on the global impact of DA by presenting emerging data on drug epidemiology in adult and pediatric populations.

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Vancomycin and linezolid: severe cutaneous adverse reactions to drugs

Li,

Han,

et al. 2024

Expert Opinion on Drug Safety

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Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population

Cited by 7 publications

References 66 publications

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

Current understanding of genetic associations with delayed hypersensitivity reactions induced by antibiotics and anti-osteoporotic drugs

Changing patterns in the epidemiology of drug allergy

Vancomycin and linezolid: severe cutaneous adverse reactions to drugs

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