2014
DOI: 10.1016/j.humimm.2014.04.016
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Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: Implication for the development of an universal CD8+ T-cell epitope-based vaccine

Abstract: A significant portion of the world’s population is infected with herpes simplex virus type 1 and/or type 2 (HSV-1 and/or HSV-2), that cause a wide range of diseases including genital herpes, oro-facial herpes, and the potentially blinding ocular herpes. While the global prevalence and distribution of HSV-1 and HSV-2 infections cannot be exactly established, the general trends indicate that: (i) HSV-1 infections are much more prevalent globally than HSV-2; (ii) Over half billion people worldwide are infected wi… Show more

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Cited by 43 publications
(68 citation statements)
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References 202 publications
(258 reference statements)
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“…Figure 2B shows the median frequencies detected in 10 SYMP individuals and 10 ASYMP individuals. The frequencies of tetramer-positive (2,4,14,36). ASYMP individuals had significantly higher percentages of CD44 high CC62L low CD8 ϩ T EM cells specific to the VP13/14 286 -294 (Fig.…”
Section: Resultsmentioning
confidence: 92%
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“…Figure 2B shows the median frequencies detected in 10 SYMP individuals and 10 ASYMP individuals. The frequencies of tetramer-positive (2,4,14,36). ASYMP individuals had significantly higher percentages of CD44 high CC62L low CD8 ϩ T EM cells specific to the VP13/14 286 -294 (Fig.…”
Section: Resultsmentioning
confidence: 92%
“…KEYWORDS granzyme B, granzyme K, HSV, herpes simplex virus, human leukocyte antigen, memory CD8 ϩ T cells, perforin, transgenic, virion phosphoprotein, humans, immunization A staggering 3.72 billion individuals worldwide (i.e., over 52% of the world's population) are currently infected with herpes simplex virus 1 (HSV-1), which causes a wide range of recurrent diseases throughout their lives (1)(2)(3). After primary (1°) ocular HSV-1 infection, the virus establishes latency in the sensory neurons of human trigeminal ganglia (TG), a state that lasts for the life of the host (1,(4)(5)(6).…”
mentioning
confidence: 99%
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“…In contrast, a low prevalence of herpes simplex virus-1 infection and disease is associated with a high frequency of the Human Leukocyte Antigen (HLA-)-B*44 allele (Samandary et al, 2014). In veterinary species, MHC class I genes have been associated with susceptibility to disease, including mastitis in cattle (Park et al, 2004).…”
Section: Statistical Analysis Of Pregnancy Outcome and Mhc Class I Gementioning
confidence: 99%