Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India

Ravikumar, M.; Dheenadhayalan, Veerabadran; Rajaram, Kanchana; Lakshmi, S. Shanmuga; Kumaran, Paul; Paramasivan, C. N.; Balakrishnan, K.; Pitchappan, Ramasamy

doi:10.1054/tuld.1999.0213

Cited by 130 publications

(93 citation statements)

References 29 publications

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“…For example, DRB1*15 has been reported to be associated with the susceptibility of TB in various ethnic groups such as Indian (Rajalingam et al, 1996;Ravikumar et al, 1999;Stroup DF et al, 2000;Sriram et al, 2001;Mishra et al, 2014;Kuranov et al, 2014), Mexican (Teran et al, 1999), Chinese (Shi et al, 2011), Polish (Dubaniewicz et al, 2005) and Korean (Kim et al, 2005). DRB1*16 is reported to have a positive association with the susceptibility to tuberculosis in Polish population (Dubaniewicz et al, 2005), but a negative association in the Sahariya tribe of North Central India (Mishra et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 13 different DRB1 alleles, namely HLA-DRB1*01, 03,04,07,08,09,10,11,12,13,14,15, and 16 were assayed. While one of the included study did not report the alleles DRB1*01 and DRB1*13 (Ravikumar et al, 1999), another did not report the DRB1*04 allele (Shi et al, 2011). Pooled ORs and 95% CIs indicated that two HLA variants namely DRB1*03 and DRB1*07 showed a protective effect against TB (P ≤ 0.05).…”

Section: Meta-analyses Of Hla-drb1 Alleles and Their Correlation To Tbmentioning

confidence: 99%

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Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

Wang²,

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association between HLA-DRB1 alleles and TB susceptibility through a systematic research. Data from eligible fifteen studies were included in the meta-analyses. Each dataset was statistically analyzed to evaluate the HLA-DRB1 alleles by calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). The results revealed that frequencies of two DRB1 alleles were significantly decreased in TB: DRB1*03 (P = 0.016, OR = 0.78, 95%CI = 0.67-0.95) and DRB1*07 (P = 0.017, OR = 0.81, 95%CI = 0.68-0.96). Thus, our data indicate that DRB1*03 and DRB1*07 may provide protective effects against TB susceptibility. However, well-designed studies with large sample sizes are required for better understanding of this association.

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Section: Discussionmentioning

confidence: 99%

Section: Meta-analyses Of Hla-drb1 Alleles and Their Correlation To Tbmentioning

confidence: 99%

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

Wang²,

et al. 2015

Genet. Mol. Res.

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“…Further various populations and caste of South India studied revealed HLA antigen disease associations as well (Brahmajothi et al 1991;Ravikumar et al 1999;Shanmugalakshmi et al 2003). Here we present the HLA polymorphism of Nadars living in Virudhunagar District of Tamil Nadu and compared them with results of selected populations of India and World.…”

Section: Introductionmentioning

confidence: 99%

HLA Antigens in Nadars a Native Dravidian Caste Group of Tamil Nadu, South India

Sridharan

Shankarkumar

2004

International Journal of Human Genetics

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One hundred and thirty seven unrelated Nadar individuals residing in Tamil Nadu, (South India) were studied for HLA A, B, C and DR locus antigen profiles. The allele frequencies of HLA A9, B5, Cw4, Cw7, DR2 and DR6 were increased while frequencies of HLA A10, B8, B16, B46, B78, Cw5, Cw9 and DR9 were decreased in the Nadars. The gene frequencies of HLA A1, A3, A28, B5, B17, B37, Cw4, Cw5, DR1, DR6 and DR10 were increased while that of A2, A19, B16, B46, Cw3, DR5 and DR9 were decreased when compared with gene frequencies of other Asian populations reported. Two Locus haplotype analyses revealed that A11-B5, A1-B17, A3-B44, A24-B51, B5-Cw9, B44-Cw1, DR4-DQ2 and DR6-DQ1 were significant haplotypes among the positive linkage disequilibrium haplotypes. Where as A1-B5, B5-Cw1 and DR1-DQ2 were significant haplotypes among the negative linkage disequilibrium haplotypes. The haplotypes A3-B44, A24-B51, B44-Cw1 and DR6-DQ1 observed in Nadars were unique when compared to other Indian populations reported in literature. The observed antigen frequencies and linkage disequilibrium in Nadars suggest the influence of genetic drift caused by selection, geography and culture with a lesser degree of admixture. Further the study reveals that the Nadar population of India cannot be considered as a single panmictic population with reference to genetic characteristics, which may have a clinical relevance in unrelated donor selection for allogenic Bone marrow transplantation in India.

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“…Other HLA loci were also found to be associated with risk and protection for TB. For example, in South India, besides HLA-DRB1*15: 01, HLA-DQB1*06: 01 were identified as conferring risk to TB, together with HLA-DPB1*04 as a marker for protection [79] . Also, two studies in Cambodia confirmed DQB1*06: 01 and adds DQB1*05: 03 alleles as risk factors for TB [80,81] .…”

Section: Pulmonary Tuberculosismentioning

confidence: 99%

HLA Loci and Respiratory Infectious Diseases

Spínola

2016

Journal of Respiratory Research

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The HLA system harbour a wide set of genes that plays an important role in the regulation and action of the immune system against invading pathogens, making them natural candidates for research on the genetic susceptibility for respiratory infections. Thus, along past decades, this topic has been subject to intense research and, consequently, several alleles of those loci have been implicated in the ability, more or less effective, to tackle and control invading pathogens in the respiratory system. Current editorial introduce, revise, summarize and comment the major advances in the role of HLA genes for the development of, and protection against, respiratory infectious disease. A general picture is drawn and new challenges on the field are relocated, especially those that might enlighten respiratory diseases aetiology and, thus, contribute in advances for diagnosis and treatment.

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Associations of HLA-DRB1, DQB1 and DPB1 alleles with pulmonary tuberculosis in south India

Cited by 130 publications

References 29 publications

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

HLA Antigens in Nadars a Native Dravidian Caste Group of Tamil Nadu, South India

HLA Loci and Respiratory Infectious Diseases

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