Associations of IL-4, IL-4R, IL-17A, and IL-17F Polymorphisms with Colorectal Cancer Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Javadirad, Etrat; Sadeghi, Masoud; Oltulu, Pembe; Sadafi, Sepehr

doi:10.1089/jir.2021.0204

Cited by 3 publications

(2 citation statements)

References 58 publications

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“…IL17A polymorphism has also been reported as a risk factor for lupus nephritis [41]. Moreover, the IL17A gene variant has been linked to an increased risk of colorectal cancer in Asians and Caucasians [86,87], osteoarthritis in Caucasians [88], IgA nephropathy in Chinese Hans [89], polycystic ovarian syndrome in Chinese people [90], diabetic nephropathy in Iranians [91], diverse cancer in Asians [92], preeclampsia in Chinese people [93], and rheumatoid arthritis in Europeans [94]. However, IL17A polymorphism has been reported to show no association with many diseases, such as European and Asian psoriasis [95], Egyptian multiple myeloma [96], and Polish periodontitis [97].…”

Section: Discussionmentioning

confidence: 99%

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

Ali

Majid

Ali

et al. 2022

JCM

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Interleukin-17A (IL17A) is a proinflammatory cytokine and is assumed to play an important role in fetal rejection. In order to evaluate the potential role of IL17A polymorphism in the pathogenesis of recurrent miscarriage (RM), serum IL17A levels were estimated by ELISA. Single-nucleotide polymorphism was assessed by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) using gene-specific primers and the EcoNI restriction enzyme. Serum IL17A levels were nonsignificantly (p > 0.5) low in RM patients compared with the control group. IL17A gene amplification by PCR yielded the undigested product of 815 bp, and its digestion with EcoNI enzyme produced 815, 529, 286, and 270 bp fragments for the GG genotype; 529, 286, and 270 bp fragments for the GA genotype; and 529 and 286 bp fragments for the AA genotype. The genotype frequency between the RM and control groups exhibited a significant difference (p = 0.001), whereas no significant difference was observed between allele frequencies in the two groups (p = 0.0954). These data suggest that the IL17A gene polymorphism exhibits no significant effect on IL17A gene expression. However, it significantly decreases and increases RM risk in the homozygous and recessive models, suggesting its potential pregnancy-protecting and -harming roles in the AA and GA + GG genotypes, respectively.

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Section: Discussionmentioning

confidence: 99%

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

Ali

Majid

Ali

et al. 2022

JCM

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“…However, the mechanism behind inflammation stimulation in cancer remains largely unknown. Cytokines are small secreted proteins that regulate the immune response by affecting nearly every cell [18] and have a correlation with cancer development [19][20][21][22]. Interleukin-6 (IL-6) is one of the most important cytokines, playing a key role in autoimmune diseases, bacterial infections, and metabolic side effects, possessing both pro-and anti-inflammatory properties [23].…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis to evaluate blood levels of interleukin-6 in lung cancer patients

Jasemi,

Zia,

Mirbahari

et al. 2023

kitp

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Introduction The exact mechanism responsible for inflammation in malignancy is not completely understood, but it is possible that interleukin-6 (IL-6) plays a major role in triggering and maintaining an inflammatory response. Aim To conduct a systematic review and meta-analysis of the levels of IL-6 in the serum/plasma of lung cancer (LC) patients. Material and methods The researchers searched four databases up to September 11, 2022, to find studies that reported on IL-6 levels in LC patients compared to healthy controls (HCs). They calculated effect sizes using standardized mean difference (SMD) with a 95% confidence interval (CI). To evaluate the quality of each study, they used the Newcastle-Ottawa Scale (NOS). They performed subgroup analysis, sensitivity analysis, meta-regression analysis, heterogeneity analyses, trial sequential analysis, and publication bias with the trim-and-fill method. Results The meta-analysis included 28 studies, and the results showed that the pooled SMD was 1.71 (95% CI: 1.22, 2.19; p < 0.00001; I 2 = 98%), indicating that LC patients had significantly higher levels of IL-6 in their serum/plasma than HCs. Conclusions The study found that the publication year and quality score of the studies were positively associated with the level of IL-6, while the sample size was inversely related. The research suggests that measuring IL-6 levels in the blood could be useful for detecting and monitoring LC as it appears to be a reliable biomarker.

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A Meta-Analysis of Association Between Interleukin Polymorphisms (rs4073, rs1800925, rs1179251, rs1179246, rs2227485, rs17855750, and rs153109) and Colorectal Cancer Risk

Sadafi,

Amirifard,

Aleagha

et al. 2024

Biochem Genet

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Associations of IL-4, IL-4R, IL-17A, and IL-17F Polymorphisms with Colorectal Cancer Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis

Cited by 3 publications

References 58 publications

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage

A systematic review and meta-analysis to evaluate blood levels of interleukin-6 in lung cancer patients

A Meta-Analysis of Association Between Interleukin Polymorphisms (rs4073, rs1800925, rs1179251, rs1179246, rs2227485, rs17855750, and rs153109) and Colorectal Cancer Risk

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