Associations of impaired sleep quality, insomnia, and sleepiness with epilepsy: A questionnaire‐based case–control study

Im, Hee-Jin; Park, Seong-Ho; Baek, Suji; Chu, Min Kyung; Yang, Kwang Ik; Kim, Won Joo; Yun, Chang-Ho

doi:10.1016/j.yebeh.2016.01.022

Cited by 59 publications

(38 citation statements)

References 37 publications

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“…40 Many other studies have found high rates of EDS, sleep fragmentation, and disturbed sleep architecture in focal epilepsy, as well as increased risk of obstructive sleep apnea. [41][42][43] Furthermore, several investigations have found that EDS and sleep disturbances are not solely related to antiepileptic medications, [44][45][46] but instead are closely associated with severity and/or duration of disease, [45][46][47] and may be accompanied by decline in quality of life. 44,48 Overall, these clinical studies suggest potential impairment of vigilance networks in focal epilepsy patients.…”

Section: Demonstrating Impaired Vigilance In Epilepsymentioning

confidence: 99%

“…In one recent neuroimaging study of mTLE patients after epilepsy surgery, we noted that certain functional connectivity alternations recovered to levels resembling those of controls in patients who became free of seizures, regardless of whether they were still taking medications. 99 Furthermore, several studies have noted impaired vigilance, 26,39 neurocognitive deficits, 24,37,38 and EDS [44][45][46] in epilepsy patients that are not fully explained by medications and often present in the absence of medications. Therefore, distinguishing the contributions of medications and subcortical network impairments to vigilance and cognition is critical to understand their clinical implications in mTLE treatment.…”

Section: Effects Of Medicationsmentioning

confidence: 99%

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Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications

2020

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Mesial temporal lobe epilepsy (mTLE) is a neurological disorder in which patients suffer from frequent consciousness‐impairing seizures, broad neurocognitive deficits, and diminished quality of life. Although seizures in mTLE originate focally in the hippocampus or amygdala, mTLE patients demonstrate cognitive deficits that extend beyond temporal lobe function—such as decline in executive function, cognitive processing speed, and attention—as well as diffuse decreases in neocortical metabolism and functional connectivity. Given prior observations that mTLE patients exhibit impairments in vigilance, and that seizures may disrupt the activity and long‐range connectivity of subcortical brain structures involved in vigilance regulation, we propose that subcortical activating networks underlying vigilance play a critical role in mediating the widespread neural and cognitive effects of focal mTLE. Here, we review evidence for impaired vigilance in mTLE, examine clinical implications and potential network underpinnings, and suggest neuroimaging strategies for determining the relationship between vigilance, brain connectivity, and neurocognition in patients and healthy controls.

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Section: Demonstrating Impaired Vigilance In Epilepsymentioning

confidence: 99%

Section: Effects Of Medicationsmentioning

confidence: 99%

Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications

2020

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“…Although society tends to accept poor sleep as the norm, it can result in considerable impairment of day time functioning and quality of life even in people without epilepsy. Different studies showed that sleep disturbance in people with epilepsy is about twice higher than among those without epilepsy [7,9,10]. The association of sleep difficulty in persons with epilepsy is a reciprocal interaction.…”

Section: Introductionmentioning

confidence: 99%

“…In the USA, magnitudes of poor sleep quality and sleep disturbance account for 72% [16] and 34% [21], respectively. According to literatures, poor sleep quality was estimated in Korea (41.1%) [10], Taiwan (50%) [22], Brazil (63.7%) [23], and India (48%) [24].…”

Section: Introductionmentioning

confidence: 99%

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Sleep Quality and Associated Factors among Peoples with Epilepsy Who Have a Follow-Up at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019: An Institutional Based Cross-Sectional Study

Adem¹,

Kassew

Birhanu

et al. 2020

Psychiatry Journal

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Background. Sleep is an active cyclic biological phenomenon and necessary for survival. Individuals who suffer from sleep disturbance are less productive, decreased performance, and negative effects on mental health. Despite there are different studies on sleep quality in Ethiopia, no studies have been conducted on magnitude and predictors of sleep quality among people with epilepsy in the study setting. Objective. To assess sleep quality and associated factors among people with epilepsy who have a follow-up at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019. Method. An institution-based cross-sectional study was employed from May-June 2019. Systematic random sampling following face to face interview technique was employed. Epi-data version 3.1 and SPSS version 25 statistical packages were used for data entry and analysis, respectively. Frequencies, proportions, means, SDs, and cross-tabulations were used to summarize descriptive statistics of the data and tables, texts, and graphs were used for data presentation. To identify association and significant predictor with the outcome variable, binary logistic regression was fitted. The variable which has statistical significance was identified on the basis of p values ≤ 0.05 and AOR with 95% confident intervals. Results. A total of 423 participants have been enrolled to the study with a response rate of 98.1%. The prevalence of poor sleep quality among peoples live with epilepsy was found 65.4% (95% CI: 61.0, 69.9). Being female (AOR=2.94; (95% CI; 1.79, 4.85)), having stress full life events (AOR=2.38; (95% CI; 1.43, 3.97)), nonadherent to AED medication (AOR=1.86; (95% CI; 1.05, 2.78), poly-therapy treatment (AOR=2.24; (95% CI; 1.05, 2.78)), poor seizer control (AOR=2.4; (95% CI; 2.21, 12.46)), comorbid medical illness (AOR=2.6; (95% CI; 1.18, 5.61)), and anxiety (AOR=2.54; (95% CI; 1.52,4.24)) were factors significantly associated with poor sleep quality. Conclusion. This study revealed that more than half of the study participants were found to have poor sleep quality. So, considering the regular assessment of sleep quality and factors associated followed with appropriate intervention is recommended among peoples living with epilepsy.

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Systematic literature review of the humanistic and economic burden of focal epilepsy and primary generalized tonic–clonic seizures in adults

Boccaletti,

Lucas,

Nixon

et al. 2024

Epilepsia Open

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This systematic literature review (SLR) assessed the humanistic and economic burden of focal epilepsy and primary generalized tonic–clonic seizures (PGTCS) in adults to evaluate these domains in both populations and identify evidence gaps to inform future research. A search was conducted on December 7, 2022, using MEDLINE and Embase to identify studies published from 2012 onwards reporting humanistic burden (patient‐reported or caregiver‐reported outcomes or utilities, qualitative evaluations), economic burden (productivity loss, caregiver and societal costs of epilepsy), and sleep‐related outcomes. Of the 2830 citations identified, 136 were included. Most studies were in the focal epilepsy population; very few studies reported outcomes in the PGTCS population. The presence of epilepsy‐specific instruments varied based on the domain evaluated. Epilepsy exerted considerable humanistic and economic burden. Indicators of poor disease control (e.g., high seizure frequency, resistance to anti‐seizure medications, polypharmacy) increased epilepsy burden. Seizure frequency and type, disease severity, and polypharmacy also affected work productivity. Adults with epilepsy, particularly focal epilepsy, reported higher indirect costs, more sick days accrued, and early entry into retirement. Caregivers similarly reported high productivity loss and absenteeism related to caregiving duties. The results of this SLR highlight the high humanistic and economic burden of focal epilepsy and PGTCS, although limited data were available for the PGTCS population. The results include patient‐reported outcome data specific to focal epilepsy and PGTCS, expanding the limited humanistic burden evidence identified in previous reviews, and show the effect of poor disease control on individuals' lives and as a driver of indirect costs.Plain Language SummaryOur systematic literature review identified studies that evaluated the impact of focal epilepsy and primary generalized tonic–clonic seizures on patients and their caregivers. We found that focal epilepsy negatively impacted patients' mental health and sleep and was associated with higher indirect costs and lower work productivity in people with more severe disease. The impact of primary generalized tonic–clonic seizures on patients was rarely reported, and future research is needed.

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Associations of impaired sleep quality, insomnia, and sleepiness with epilepsy: A questionnaire‐based case–control study

Cited by 59 publications

References 37 publications

Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications

Impaired vigilance networks in temporal lobe epilepsy: Mechanisms and clinical implications

Sleep Quality and Associated Factors among Peoples with Epilepsy Who Have a Follow-Up at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia, 2019: An Institutional Based Cross-Sectional Study

Systematic literature review of the humanistic and economic burden of focal epilepsy and primary generalized tonic–clonic seizures in adults

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