Associations of lead and cadmium with sex hormones in adult males

Kresovich, Jacob K.; Argos, Maria; Turyk, Mary E.

doi:10.1016/j.envres.2015.05.026

Cited by 68 publications

(35 citation statements)

References 35 publications

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“…Our results are consistent with several population-based studies conducted in U.S. men1023, Croatian men24 and U.S. postmenopausal women825. Nevertheless, Meeker et al 9.…”

Section: Discussionsupporting

confidence: 92%

“…Based on the study conducted by Kresovich et al 10,. we further investigated potential interactions of the associations between BLLs and reproductive hormone levels in relation to smoking status, dysglycaemia, BMI, and blood cadmium level.…”

Section: Methodsmentioning

confidence: 99%

“…we further investigated potential interactions of the associations between BLLs and reproductive hormone levels in relation to smoking status, dysglycaemia, BMI, and blood cadmium level. These potential interactions were evaluated based on a cross-product interaction term for the ordinal variable representing BLL quartiles and categorical variables indicating smoking status (current versus former and never combined), glucose status (dysglycaemia versus normal), exposure to cadmium above the median level (median BCL = 1.91 μg/L for men and 1.41 μg/L for postmenopausal women), or BMI (underweight/normal, overweight, and obese)10.…”

Section: Methodsmentioning

confidence: 99%

“…Meeker et al 9. reported that BLLs in men were not associated with total testosterone (TT), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and sex-hormone binding globulin (SHBG) levels, whereas data from NHANES 1999–2004 showed a positive association between lead exposure and testosterone levels in men10.…”

mentioning

confidence: 99%

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Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

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We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin(SHBG) levels were measured. The results showed that median values (interquartile range) of BLLs were 44.00 μg/L (29.00–62.30) for men and 41.00 μg/L (27.00–59.81) for postmenopausal women. In linear regression, after adjusting for age, current smoking status, body mass index, systolic blood pressure, diabetes and blood cadmium level, TT (P for trend = 0.001) and SHBG (P for trend < 0.001) levels were still positively associated with BLLs in men. Meanwhile, significant positive associations were found for BLLs with SHBG (P for trend = 0.002), FSH (P for trend = 0.001) and LH (P for trend = 0.026) levels in postmenopausal women. Additionally, the association between BLL and SHBG was modified by dysglycaemia (P for interaction = 0.03) in postmenopausal women. In conclusion, BLLs were associated with reproductive hormone levels in the general population of Chinese men and postmenopausal women, which may have important implications for human health. Concerted efforts to reduce adult lead exposure are warranted.

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“…Our results are consistent with several population-based studies conducted in U.S. men1023, Croatian men24 and U.S. postmenopausal women825. Nevertheless, Meeker et al 9.…”

Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

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“…The major exposure pathways of cadmium to human beings are the consumption of liver and kidney meat and cigarette smoking. Evidence exists for the association of cadmium levels and sex hormones in adult males [12]. The toxic nature of cadmium forces that it is essential to determine its concentration in environmental samples.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of 4-Benzyloxybenzaldehyde-4-methyl-3-thiosemicarbazone (Containing Sulphur and Nitrogen Donor Atoms) and Its Cd(II) Complex

Suvarapu

Baek

2015

Metals

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Abstract:A chelating agent, 4-benzyloxybenzaldehyde-4-methyl-3-thiosemicarbazone (BBMTSC), containing sulphur and nitrogen donor atoms was synthesized and applied as a ligand for the chelation of Cd(II). Both the BBMTSC and its Cd(II) complex were characterized by elemental analysis, UV-Vis absorption spectra, Fourier transform infrared spectroscopy (FT-IR), mass spectra, nuclear magnetic resonance spectroscopy (NMR), X-ray powder diffraction (XRD), and field emission scanning electron microscopy (FESEM). The FTIR spectra confirmed the formation of both BBMTSC and its Cd(II) complex. XRD revealed the polycrystalline nature of the synthesized compounds. BBMTSC exhibited a flake-like micro-rod morphology, whereas the Cd(II) complex had a flower-like nanorod structure.

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Environmental and occupational exposure to cadmium associated with male reproductive health risk: a systematic review and meta-analysis based on epidemiological evidence

Gao

Pan

et al. 2023

Environ Geochem Health

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Associations of lead and cadmium with sex hormones in adult males

Cited by 68 publications

References 35 publications

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Synthesis and Characterization of 4-Benzyloxybenzaldehyde-4-methyl-3-thiosemicarbazone (Containing Sulphur and Nitrogen Donor Atoms) and Its Cd(II) Complex

Environmental and occupational exposure to cadmium associated with male reproductive health risk: a systematic review and meta-analysis based on epidemiological evidence

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