Associations of Leisure-Time and Occupational Physical Activity and Cardiorespiratory Fitness With Incident and Recurrent Major Depressive Disorder, Depressive Symptoms, and Incident Anxiety in a General Population

Baumeister, Sebastian E.; Leitzmann, Michael F.; Bahls, Martin; Dörr, Marcus; Schmid, Daniela; Schomerus, Georg; Appel, Katja; Markus, Marcello R. P.; Völzke, Henry; Gläser, Sven; Grabe, Hans‐Jörgen

doi:10.4088/jcp.15m10474

Cited by 49 publications

(31 citation statements)

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“…One study was found using the reference lists of previously published studies. In total, 14 cohorts of 13 unique prospective studies were included in this review (Baumeister et al, 2017;Beard, Heathcote, Brooks, Earnest, & Kelly, 2007;Cynthia et al, 2011;Da Silva et al, 2012;Jonsdottir, Rodjer, Hadzibajramovic, Borjesson, & Ahlborg, 2010;Kang et al, 2015;McDowell, Gordon, Andrews, MacDonncha, & Herring, 2018;Muller, Ganeshamoorthy, & Myers, 2017;Pasco et al, 2011;Sanchez-Villegas et al, 2008;Strohle et al, 2007;Ten Have, de Graaf, & Monshouwer, 2011;Zainal & Newman, 2018).…”

Section: Search Resultsmentioning

confidence: 99%

Physical activity protects from incident anxiety: A meta‐analysis of prospective cohort studies

et al. 2019

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Background Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta‐analysis has been conducted. Aims To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow‐up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle‐Ottawa Scale (NOS). A random‐effects meta‐analysis was conducted and heterogeneity was explored using subgroup and meta‐regression analysis. Results Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1%) followed for 357,424 person‐years, people with high self‐reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95% confidence level [95% CI] = 0.62, 0.88; crude OR = 0.80; 95% CI = 0.69, 0.92). High self‐reported PA was protective against the emergence of agoraphobia (AOR = 0.42; 95% CI = 0.18, 0.98) and posttraumatic stress disorder (AOR = 0.57; 95% CI = 0.39, 0.85). The protective effects for anxiety were evident in Asia (AOR = 0.31; 95% CI = 0.10, 0.96) and Europe (AOR = 0.82; 95% CI = 0.69, 0.97); for children/adolescents (AOR = 0.52; 95% CI = 0.29, 0.90) and adults (AOR = 0.81; 95% CI = 0.69, 0.95). Results remained robust when adjusting for confounding factors. Overall study quality was moderate to high (mean NOS = 6.7 out of 9). Conclusion Evidence supports the notion that self‐reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.

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Section: Search Resultsmentioning

confidence: 99%

Physical activity protects from incident anxiety: A meta‐analysis of prospective cohort studies

et al. 2019

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“…To investigate the role of miR-532-5p in neuroinflammation, we further detected the inflammatory cytokines in mice exposed to CUMS. Compared with the control group, the expression of iNOS in the hippocampus of CUMS mice was increased significantly (ANOVA, F (3,20) = 60.002, p = 0.000; LSD test, t =−11.757, p = 0.000) (p < 0.01, Figure 3A and B), and overexpression of miR-532-5p significantly inhibited the increased expression of iNOS (ANOVA, F (3,20) = 60.002, p = 0.000; LSD test, t =7.821, p = 0.000) (p < 0.01, Figure 3A and B). The expression of IL-6, IL-1β, TNF-α and MCP-1 in hippocampus of CUMS mice were significantly increased (IL-6, ANOVA, F (3,20) = 72.672, p = 0.000; LSD test, t =−11.763, p = 0.000; IL-1.0 ANOVA, F (3,20) = 29.012, p = 0.000; LSD test, t =−7.531, p = 0.000; TNF-., ANOVA, F (3,20) = 21.476, p = 0.000; LSD test, t =−7.485, p = 0.000; MCP-1, ANOVA, F (3,20) = 99.092, p = 0.000; LSD test, t =−7.485, p = 0.000)(p < 0.01, Figure 3B-E), while miR-532-5p overexpression significantly inhibited the increased expression of cytokines (IL-6, ANOVA, F (3,20) = 72.672, p = 0.000; LSD test, t =4.555, p = 0.010; IL-1β, ANOVA, F (3,20) = 29.012, p = 0.000; LSD test, t = 4.717, p = 0.001; TNF-α, ANOVA, F (3,20) = 21.476, p = 0.000; LSD test, t =3.145, p = 0.035; MCP-1, ANOVA, F (3,20) = 99.092, p = 0.000; LSD test, t =3.600, p = 0.023) (p < 0.05, p < 0.01, Figure 3B-E).…”

Section: Overexpression Of Mir-532-5p Improved Depressive-like Behavimentioning

confidence: 98%

“…Major depressive disorder (MDD) is one of the most prevalent forms of mental disorders that affect millions of individuals worldwide 1 and exerts substantial public health and financial costs to society. Although the symptoms of MDD have been widely acknowledged and recognized by clinicians, 2,3 due to the lack of effective targets for diagnosis and treatment, the incidence rate and mortality rate of MDD increase year by year. 4 Hence, the well understanding of specific molecular mechanisms involved in the development of laryngeal cancer is more urgent and will contribute to identify efficient targets for the diagnosis and treatment.…”

Section: Introductionmentioning

confidence: 99%

<p>MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3</p>

Xue¹,

Zeng²,

Zhu³

et al. 2020

NDT

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Background It is known that miR-532-5p is critical for neuronal differentiation. However, the role of miR-532-5p in depression remains unknown. This study aimed to investigate the role and mechanism of miR-532-5p in major depressive disorder (MDD). Methods The depression mice model was established by chronic unpredictable mild stress (CUMS) and confirmed by forced swimming test (FST) and sucrose preference test (SPT). The role of miR-532-5p in MDD was detected by tail suspension test (TST), FST, SPT and SIT. QRT-PCR was used to detect the expression of miR-139-5p in hippocampus and BV-2 microglia of mice. ELISA and Western blotting were used to detect the expression of the nitric oxide synthase (NOS), proinflammatory cytokines (IL-6, IL-1β, TNF-α, and MCP-1) and transcriptional activator 3 (STAT3). Luciferase reporter assay was used to verify the downstream target genes of miR-532-5p. Results MiR-532-5p was significantly reduced in the hippocampus of mice treated with CUMS. Overexpression of miR-532-5p significantly reduced CUMS-induced depression-like behaviors and suppressed the expression of IL-6, IL-1β, TNF-α and MCP-1. MiR-532-5p directly targeted signal transducers and STAT3 in BV2 cells. In addition, overexpression of miR-532-5p restrained the raise of inducible NOS and IL-6, IL-1 β, TNF-α and MCP-1 in LPS-exposed BV2 cells. Conclusion This study indicates that miR-532-5p plays an important role in CUMS-induced depression-like behaviors by targeting STAT3, and miR-532-5p may be a potential target for MDD therapy.

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“…Several studies of the general population have found that people who engage in more PA have a reduced risk of being diagnosed with an anxiety disorder and less frequent and severe anxiety symptoms [ 47 – 52 ]⁠. Conversely, physical inactivity has been identified as a risk factor for the development of anxiety [ 53 ]⁠ as well as for other conditions such as depression [ 54 – 56 ]⁠.…”

Section: Physical Activity and Anxiety: Current Evidencementioning

confidence: 99%

Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety

Kandola

Vancampfort

Herring

et al. 2018

Curr Psychiatry Rep

196

121

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Purpose of ReviewThe purpose of this paper was to provide a comprehensive narrative review of the relationship between physical activity (PA) and anxiety and the rationale for including it as a treatment option for anxiety disorders. Several gaps in the literature are highlighted alongside recommendations for future research.Recent FindingsPA in the general population has established efficacy in preventing and managing cardiovascular disease and improving wellbeing. Recent epidemiological data further suggests that people who are more active may be less likely to have anxiety disorders. In addition, evidence from systematic reviews of randomised control trials suggests that exercise training, a subset of PA, can reduce symptoms in anxiety and stress-related disorders, such as post-traumatic stress disorder, agoraphobia and panic disorder.SummaryAnxiety disorders are common, burdensome and costly to individuals and wider society. In addition to the profound negative impact on individuals’ wellbeing and functioning, they are associated with worsened physical health, including a higher risk for cardiovascular diseases and premature mortality. Although pharmacotherapy and psychological interventions are helpful for many, these treatment approaches are not effective for everyone and are insufficient to address common physical health complications, such as the elevated risk of cardiovascular disease. Given the combined anxiolytic and physical health benefits of increased activity, PA presents a promising additional treatment option for people with anxiety disorders. However, there remain key gaps in the literature regarding the mechanisms underlying the effects of PA, optimal PA protocols, methods of improving adherence and the importance of physical fitness. These must be addressed for PA to be successfully implemented in mental health services.

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Associations of Leisure-Time and Occupational Physical Activity and Cardiorespiratory Fitness With Incident and Recurrent Major Depressive Disorder, Depressive Symptoms, and Incident Anxiety in a General Population

Abstract: Greater cardiorespiratory fitness but not domain-specific physical activity was associated with a lower incidence of MDD and clinical anxiety.

Cited by 49 publications

References 0 publications

Physical activity protects from incident anxiety: A meta‐analysis of prospective cohort studies

Physical activity protects from incident anxiety: A meta‐analysis of prospective cohort studies

<p>MiRNA-532-5p Regulates CUMS-Induced Depression-Like Behaviors and Modulates LPS-Induced Proinflammatory Cytokine Signaling by Targeting STAT3</p>

Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety

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