Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study.

Sharrett, A. Richey; Patsch, Wolfgang; Sorlie, Paul D.; Heiss, Gerardo; Bond, M. Gene; Davis, C. E.

doi:10.1161/01.atv.14.7.1098

Cited by 176 publications

(111 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…31,32 The association between carotid and coronary atherosclerosis is only marginally increased when information of IMT from the internal carotid and carotid bulb are added to the common carotid IMT, supporting that the use of common carotid IMT may be preferable for certain analyses. 31 IMT measurements of the common carotid artery correlate significantly with traditional risk factors, 4,[33][34][35] with the occurrence of cerebrovascular disease, 6,36 and with the severity and extent of coronary heart disease. 10 Although IMT values cannot be used to predict the risk of coronary heart disease on an individual basis, 10 they can nevertheless predict the likelihood of cardiovascular events in population groups.…”

Section: Table 3 Linear Regression Coefficients On the Relation Of Imentioning

confidence: 97%

Westernization of Chinese Adults and Increased Subclinical Atherosclerosis

Woo

Chook

Raitakari

et al. 1999

ATVB

115

View full text Add to dashboard Cite

Abstract-Cardiovascular event rates are much lower in China compared with developed countries. "Westernization" of diet and lifestyle in the Chinese, however, may lead to an increased prevalence of atherosclerosis-related diseases. Because carotid intima-media thickness (IMT) is a marker of subclinical atherosclerosis, we examined IMT and vascular risk profile in community-based groups of rural Chinese, Westernized urban Chinese, and urban whites. Mean IMT of the common carotid artery was measured in 348 healthy adults, aged 42Ϯ13 years (range 21 to 71 years); 116 subjects from rural China, 116 urban Chinese subjects living in Hong Kong or in Australia, and 116 urban Caucasians living in Australia. These 3 groups were matched for age, sex, and cigarette smoke exposure. Urban Chinese subjects had slightly better risk factor profile (higher HDL-cholesterol and lower blood pressure) compared with rural Chinese subjects. Despite this, however, the mean IMT was lowest in rural Chinese (0.50Ϯ0.10 mm), intermediate in urban Chinese (0.56Ϯ0.12 mm), and highest in urban whites (0.64Ϯ0.13 mm) (PϽ0.001 for comparisons between all groups). These differences in IMT were not altered after adjustment for the major traditional cardiovascular risk factors (serum lipids, smoking, and blood pressure or for body mass index). The influence of vascular risk factors on atherosclerosis between urban versus rural Chinese subjects was studied by multivariate regression models and by comparing the steepness of regression slopes between risk factors and IMT in the subject groups. The effects of smoking, HDL-cholesterol, and triglycerides on IMT were significantly greater in the urban compared with the rural Chinese (PϽ0.01). These data suggest that Westernization of Chinese subjects is associated with greater susceptibility to the pro-atherogenic effects of traditional vascular risk factors, such as lipids and smoking, and with evidence of increased IMT as a marker of subclinical atherosclerosis.

show abstract

Section: Table 3 Linear Regression Coefficients On the Relation Of Imentioning

confidence: 97%

Westernization of Chinese Adults and Increased Subclinical Atherosclerosis

Woo

Chook

Raitakari

et al. 1999

ATVB

115

View full text Add to dashboard Cite

show abstract

“…Analytical methods used to determine total cholesterol, LDL-C, TG, HDL-C, HDL 3 , apoB, and apoA-I have been previously described in detail (24). Cholesterol and TG were measured by enzymatic procedures (25,26), with reagents from Boehriner Mannheim Biochemical (analysis adapted for use in Cobas-Bio Analyzer, Roche).…”

Section: Plasma Hdl-cholesterol and Other Relevant Variablesmentioning

confidence: 99%

Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults

et al. 2007

View full text Add to dashboard Cite

Polymorphisms in genes involved in HDL-cholesterol (HDL-C) metabolism influence plasma HDL-C concentrations. We examined whether dietary fat intake modified relations between HDL-C and polymorphisms in hepatic lipase (LIPC-514C→T), cholesteryl ester transfer protein (CETP TaqIB), and lipoprotein lipase (LPL S447X) genes. Diet (food frequency questionnaire), plasma lipids, and LIPC, CETP, and LPL genotypes were assessed in ~12,000 White and African American adults. In both races and all genotypes studied, minor allele homozygotes had highest HDL-C concentrations compared to the other genotypes (P <0.001). However, main effects were modified by usual dietary fat intake. In African Americans-women somewhat more strongly than men-LIPC TT homozygotes with fat intake ≥33.2% of energy had ~3-4 mg/dL higher HDL-C concentrations than CC and CT genotypes. In contrast, when fat intake was <33.2% of energy, TT homozygotes had HDL-C concentrations ~3.5 mg/dL greater than those with the CC genotype but not different from those with the CT genotype (P interaction =0.013). In Whites, LPL GG homozygotes had greatest HDL-C at lower total, saturated, and monounsaturated fat intakes but lowest HDL-C at higher intakes of these fats (P interaction ≤0.002). Dietary fat did not modify associations between CETP and HDL-C. In conclusion, these data show that plasma HDL-C differs according to LIPC, LPL, and CETP genotypes. In the case of LIPC and LPL, data suggest dietary fat modifies these relations.

show abstract

“…This seems consistent, but somewhat modest, in the apoE-KO mouse. Should such studies reinforce our confidence, modern imaging modalities such as electron beam CT of the coronary 44 or ultrasonography of the carotid arteries 45 afford noninvasive approaches to assess the impact of TP antagonism on plaque progression in humans. Reagents are now available for the study of TP expression in human disease, 46 and model systems have implicated TP activation in settings previously not considered when these drugs were under development.…”

Section: See Page 1724mentioning

confidence: 99%