Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort

Brasky, Theodore M.; Neuhouser, Marian L.; Cohn, David E.; White, Emily

doi:10.3945/ajcn.113.070524

Cited by 25 publications

(40 citation statements)

References 44 publications

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“…Inverse associations are not supported by previous studies, which have found no associations between intakes of these fatty acids and risk of endometrial cancer (16,17,29).…”

Section: Discussioncontrasting

confidence: 45%

“…Nevertheless, the reductions in risk we observed with high intakes of α-linolenic acid or linolenic acid in women with BMIs less than 25 complicate the interpretation of the LC ω-3 PUFA data. In previous studies, there was some evidence of an inverse association between LC ω-3 PUFA intake and risk of type I (i.e., endometrioid) endometrial cancers (16,17). Only 60% of endometrial cancer cases in the BWHS had medical record data available for abstraction of histological subtype, leaving too few cases for subtype analysis here.…”

Section: Discussionmentioning

confidence: 99%

“…Findings are somewhat inconsistent. Among postmenopausal women in the VITAL Study (<1% African-American), a cohort study of women living in the Seattle-Puget Sound, Washington, area, we previously reported that hazard ratios for endometrial cancer associated with intakes of LC ω-3 PUFAs were 1.66 (95% CI: 1.09, 1.55) and 1.79 (95% CI: 1.16, 1.75) for EPA and EPA + DHA, respectively (16). However, there were clear differences in the associations when the analysis was stratified on BMI.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers in 2 prospective cohort studies (16,17) and 1 population-based case-control study (29) have reported on associations between LC ω-3 PUFAs and endometrial cancer risk in predominantly white study populations. Findings are somewhat inconsistent.…”

Section: Discussionmentioning

confidence: 99%

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Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Brasky¹,

Sponholtz²,

Palmer³

et al. 2016

Am. J. Epidemiol.

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Dietary long-chain (LC) ω-3 polyunsaturated fatty acids (PUFAs), which derive primarily from intakes of fatty fish, are thought to inhibit inflammation and de novo estrogen synthesis. This study prospectively examined the associations of dietary LC ω-3 PUFAs and fish with endometrial cancer risk in 47,602 African-American women living in the United States, aged 21-69 years at baseline in 1995, and followed them until 2013 (n = 282 cases). Multivariable-adjusted Cox regression models estimated hazard ratios and 95% confidence intervals for associations of LC ω-3 PUFA (quintiled) and fish (quartiled) intake with endometrial cancer risk, overall and by body mass index (BMI; weight (kg)/height (m) 2 ). The hazard ratio for quintile 5 of total dietary LC ω-3 PUFAs versus quintile 1 was 0.79 (95% confidence interval (CI): 0.51, 1.24); there was no linear trend. Hazard ratios for the association were smaller among normal-weight women (BMI <25: hazard ratio (HR) = 0.53, 95% CI: 0.18, 1.58) than among overweight/ obese women (BMI ≥25: HR = 0.88, 95% CI: 0.54, 1.43), but these differences were not statistically significant. Fish intake was also not associated with risk (quartile 4 vs. quartile 1: HR = 0.86, 95% CI: 0.56, 1.31). Again hazard ratios were smaller among normal-weight women (HR = 0.65) than among overweight/obese women (HR = 0.94). While compatible with no association, the hazard ratios observed among leaner African-American women are similar to those from recent prospective studies conducted in predominantly white populations.African-American women; docosahexaenoic acid; eicosapentaenoic acid; endometrial cancer; fish; uterine cancer; women's reproductive health Abbreviations: BMI, body mass index; BWHS, Black Women's Health Study; CI, confidence interval; DHA, docosahexaenoic acid; DPA, docosapentaenoic acid; EPA, eicosapentaenoic acid; FFQ, food frequency questionnaire; HR, hazard ratio; LC, long-chain; PUFA, polyunsaturated fatty acid; VITAL, Vitamins and Lifestyle; WHI, Women's Health Initiative.Endometrial cancer is the fourth most common cancer and the leading gynecological malignancy diagnosed in US women (1). Incidence rates are about 9% lower for African-American women relative to white women (2), but a recent study of Surveillance, Epidemiology, and End Results data that corrected for hysterectomy prevalence indicated a higher incidence in black women (3).

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“…Inverse associations are not supported by previous studies, which have found no associations between intakes of these fatty acids and risk of endometrial cancer (16,17,29).…”

Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Brasky¹,

Sponholtz²,

Palmer³

et al. 2016

Am. J. Epidemiol.

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“…22.494 kadın bireyin yer aldığı VİTAL çalışmasında (VITamins and Lifestyle) balık tü-ketimi veya besin desteği ile alınan EPA ve DHA'nın hafif şişman ve obez kadınlarda endometriyal (rahim kanseri) kanser riskini artırdığı, normal vücut ağırlığına sahip kadınlarda ise riski azalttığı sonucuna varılmıştır (Brasky, Neuhouser, Cohn, & White, 2014). Deniz ürünleri tüketimi ve prostat kanser gelişimi arasındaki ilişkinin incelendiği bir meta-analizde 31 çalışmanın 17'sinde herhangi bir ilişki bulunmazken, 6'sında riskin azaldığı, 2'sinde ise riskin arttığı gösteril-miş, geriye kalanlarda ise net bir sonuç elde edilmemiştir (Lovegrove et al, 2015).…”

Section: Kanserunclassified

Benefits of Fish Consumption for Healthy and Balanced Nutrition During Lifelong Time

Öksüz¹,

Alkan²,

Taşkın³

et al. 2018

Food Health

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Öz:Balık, yaşamın her döneminde sağlığın korunması ve gelişmesine katkıda bulunan bir besindir. İyi kalitede protein, uzun zincirli çoklu doymamış n-3 yağ asitleri (n-3 LCPUFA), D vitamini, iyot gibi besin öğelerini içermesi nedeniyle balıketinin düzenli ve yeterli miktarda tüketimi önerilmektedir. Özellikle fetüsün bilişsel ve görsel gelişimi için gerekli olan dokosahexaenoik asit (DHA) gebelik döneminde annenin balık tüketimine bağlıdır. Yaşamın ilk döneminde bebek için en iyi besin olan anne sütünün DHA içeriği de büyüme ve gelişimin tamamlanması açısından önemli-dir. Çocukluk çağında düzenli balık tüketim alışkanlığı kazandı-rılmasının kronik hastalıkların önlenmesine katkıda bulunduğu bildirilmektedir. Yetişkinlik ve yaşlılık döneminde de balıketi sağlığın korunması için yeterli ve dengeli bir diyetin vazgeçilmez bir parçasıdır. Genel olarak haftada iki porsiyon yağlı balık tüke-timi önerilmektedir. Ancak balıkta doğal olarak bulunmayan ve balığın avlandığı/yetiştirildiği su kaynaklarından balığa geçen metilcıva (MeHg) ve dioksin benzeri bileşikler sağlığı olumsuz etkilemektedir. MeHg'nin özellikle fetüs ve yeni doğan için nö-rotoksik olduğu bildirilmektedir. MeHg içeriği yüksek olan ceylan palamutu Scomberomorus commerson (Lacepède, 1800), kö-pek balığı, kılıç balığı, irigöz ton balıklarının tüketilmemesi öne-rilmektedir. Yarar risk analizi yapıldığında balık tüketimin yararlarının daha ağır bastığı bildirilmektedir, yaşamın her döneminde düzenli olarak balık tüketimi optimal beslenme için önemlidir.

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A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk

Luu

Cai

Murff

et al. 2018

Intl Journal of Cancer

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Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti-inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population-based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men). Dietary fatty acid intakes were derived from data collected at the baseline using validated food frequency questionnaires (FFQs). Cox proportional hazards model was performed to assess the association between PUFAs and lung cancer risk. Total, saturated and monounsaturated fatty acid intakes were not significantly associated with lung cancer risk. Total PUFAs intake was inversely associated with lung cancer risk [HRs and respective 95% CIs for quintiles 2-5 vs quintile 1: 0.84 (0.71-0.98), 0.97 (0.83-1.13), 0.86 (0.74-1.01) and 0.85 (0.73-1.00), p = 0.11]. However, DHA intake was positively associated with lung cancer risk [HRs and 95% CIs: 1.01 (0.86-1.19), 1.20 (1.03-1.41), 1.21 (1.03-1.42) and 1.24 (1.05-1.47), p = 0.001]. The ratio of n-6 PUFAs to n-3 PUFAs (i.e., 7:1) was inversely associated with lung cancer risk, particularly among never-smokers and adenocarcinoma patients. Total PUFAs and the ratio between n-6 PUFAs and n-3 PUFAs were inversely associated with lung cancer risk. This study highlights an important public health impact of PUFA intakes toward intervention/prevention programs of lung cancer.

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Associations of long-chain ω-3 fatty acids and fish intake with endometrial cancer risk in the VITamins And Lifestyle cohort

Abstract: The overall increased risk reported here confirms the findings of several prior observational studies of fish intake, which observed similar increases in risk. Randomized trials are needed to confirm these findings.

Cited by 25 publications

References 44 publications

Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Associations of Dietary Long-Chain ω-3 Polyunsaturated Fatty Acids and Fish Consumption With Endometrial Cancer Risk in the Black Women's Health Study

Benefits of Fish Consumption for Healthy and Balanced Nutrition During Lifelong Time

A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk

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